SPRY2 | ENSG00000136158 | NCBI 10253

Details for: SPRY2

Gene ID: 10253

Symbol: SPRY2

Ensembl ID: ENSG00000136158

Description: sprouty RTK signaling antagonist 2

Associated with

Egfr downregulation
(R-HSA-182971)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Signaling by egfr
(R-HSA-177929)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Spry regulation of fgf signaling
(R-HSA-1295596)
Actin cytoskeleton
(GO:0015629)
Animal organ development
(GO:0048513)
Bud elongation involved in lung branching
(GO:0060449)
Cell fate commitment
(GO:0045165)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of mitotic spindle orientation
(GO:0000132)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Inner ear morphogenesis
(GO:0042472)
Lung growth
(GO:0060437)
Membrane
(GO:0016020)
Microtubule cytoskeleton
(GO:0015630)
Microtubule end
(GO:1990752)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cell projection organization
(GO:0031345)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of lens fiber cell differentiation
(GO:1902747)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of neurotrophin trk receptor signaling pathway
(GO:0051387)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of ras protein signal transduction
(GO:0046580)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Negative regulation of vascular endothelial growth factor signaling pathway
(GO:1900747)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein serine/threonine kinase inhibitor activity
(GO:0030291)
Ruffle membrane
(GO:0032587)
Sensory perception of sound
(GO:0007605)
Ubiquitin-protein transferase inhibitor activity
(GO:0055105)

Other Information

Proteins

Protein sprouty homolog 2

Genular Protein ID: 3050276979

Symbol: SPY2_HUMAN

Name: Protein sprouty homolog 2

UniProtKB Accession Codes:

O43597 B2R9J9 Q5T6Z7

Database IDs:

Citations:

PubMed ID: 9458049

Title: Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

PubMed ID: 9458049

DOI: 10.1016/s0092-8674(00)80919-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10887178

Title: Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.

PubMed ID: 10887178

DOI: 10.1074/jbc.m002156200

PubMed ID: 16877379

Title: A functional interaction between sprouty proteins and caveolin-1.

PubMed ID: 16877379

DOI: 10.1074/jbc.m603921200

PubMed ID: 12717443

Title: Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

PubMed ID: 12717443

DOI: 10.1038/ncb978

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21288888

Title: Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate.

PubMed ID: 21288888

DOI: 10.1093/jb/mvr017

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29408807

Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

PubMed ID: 29408807

DOI: 10.1172/jci97350

PubMed ID: 25782674

Title: A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy.

PubMed ID: 25782674

DOI: 10.1038/ejhg.2015.52

Sequence Information:

Length: 315
Mass: 34688
Checksum: 8CC6256929D91A7E
Sequence:

MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS 
STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED 
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 
CKVPTVPPRN FEKPT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPRY2

Associated with

Other Information

Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. PubMed ID: 9458049

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. PubMed ID: 10887178

A functional interaction between sprouty proteins and caveolin-1. PubMed ID: 16877379

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. PubMed ID: 12717443

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate. PubMed ID: 21288888

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. PubMed ID: 29408807

A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy. PubMed ID: 25782674