Details for: SPRY2

Gene ID: 10253

Symbol: SPRY2

Ensembl ID: ENSG00000136158

Description: sprouty RTK signaling antagonist 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.11
    Marker Score: 71,741
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.69
    Marker Score: 1,806
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.6
    Marker Score: 913
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.51
    Marker Score: 52,296
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.44
    Marker Score: 3,975
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2,429
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.21
    Marker Score: 25,846
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18,468
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1,214
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.15
    Marker Score: 2,833
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.15
    Marker Score: 264
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.13
    Marker Score: 1,211
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.09
    Marker Score: 5,366
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.05
    Marker Score: 10,668
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.04
    Marker Score: 1,606
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,753
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.01
    Marker Score: 1,125
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,770
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,995
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2,318
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.98
    Marker Score: 1,360
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.97
    Marker Score: 611
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.95
    Marker Score: 521
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.94
    Marker Score: 888
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5,668
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1,867
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,722
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.91
    Marker Score: 224
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.9
    Marker Score: 373
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,980
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,262
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.87
    Marker Score: 1,015
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 518
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.86
    Marker Score: 563
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.85
    Marker Score: 265
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 399
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.83
    Marker Score: 1,040
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.81
    Marker Score: 7,697
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.79
    Marker Score: 498
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.74
    Marker Score: 303
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.73
    Marker Score: 1,790
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.73
    Marker Score: 181
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.72
    Marker Score: 181
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.72
    Marker Score: 6,174
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.72
    Marker Score: 715
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,939
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 633
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.69
    Marker Score: 332
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.69
    Marker Score: 4,467
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.68
    Marker Score: 589
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.67
    Marker Score: 646
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.66
    Marker Score: 813
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.65
    Marker Score: 6,109
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.64
    Marker Score: 302
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.64
    Marker Score: 162
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.63
    Marker Score: 976
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.63
    Marker Score: 1,704
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.62
    Marker Score: 274
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.61
    Marker Score: 582
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.6
    Marker Score: 1,562
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.59
    Marker Score: 221
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.59
    Marker Score: 385
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.58
    Marker Score: 174
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.58
    Marker Score: 704
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.58
    Marker Score: 140
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 185
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.57
    Marker Score: 610
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.56
    Marker Score: 628
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.56
    Marker Score: 476
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.55
    Marker Score: 33,952
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.55
    Marker Score: 536
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 370
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.52
    Marker Score: 1,244
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.52
    Marker Score: 5,264
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.52
    Marker Score: 642
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.52
    Marker Score: 304
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.51
    Marker Score: 236
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.51
    Marker Score: 174
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.51
    Marker Score: 2,138
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.51
    Marker Score: 661
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.51
    Marker Score: 1,014
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.51
    Marker Score: 270
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.5
    Marker Score: 272
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.5
    Marker Score: 243
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5
    Marker Score: 846
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.5
    Marker Score: 173
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.5
    Marker Score: 18,324

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Sprouty proteins, including SPRY2, belong to the Sprouty family of proteins, which are known for their ability to modulate receptor tyrosine kinase (RTK) signaling. SPRY2 is a specific member of this family and is characterized by its ability to inhibit the activity of multiple RTKs, including epidermal growth factor receptor (EGFR), fibroblast growth factor receptors (FGFRs), and vascular endothelial growth factor receptors (VEGFRs). This inhibition occurs through the binding of SPRY2 to the phosphorylated tyrosine residues of these receptors, thereby preventing the recruitment of downstream signaling molecules and the activation of downstream pathways. **Pathways and Functions** The SPRY2 gene is involved in numerous signaling pathways that regulate various cellular processes, including: 1. **Cell Migration**: SPRY2 regulates the migration of fibroblasts and endothelial cells by inhibiting the activity of RTKs that are involved in cell motility and adhesion. 2. **Cell Differentiation**: SPRY2 modulates the differentiation of satellite stem cells and cardiac muscle myoblasts by regulating the activity of RTKs that are involved in cell fate commitment. 3. **Proliferation**: SPRY2 regulates the proliferation of fibroblasts and epithelial cells by inhibiting the activity of RTKs that are involved in cell growth and division. 4. **Angiogenesis**: SPRY2 regulates angiogenesis by inhibiting the activity of VEGFRs, which are involved in the formation of new blood vessels. 5. **Apoptosis**: SPRY2 modulates apoptosis by regulating the activity of RTKs that are involved in cell survival and death. **Clinical Significance** Dysregulation of SPRY2 has been implicated in several diseases, including: 1. **Cancer**: SPRY2 is often downregulated in cancer cells, leading to uncontrolled cell growth and tumor formation. 2. **Angiogenesis-related disorders**: SPRY2's role in inhibiting angiogenesis suggests that its dysregulation may contribute to the development of angiogenesis-related disorders, such as diabetic retinopathy and age-related macular degeneration. 3. **Cardiovascular disease**: SPRY2's role in regulating cell migration and differentiation suggests that its dysregulation may contribute to the development of cardiovascular disease. 4. **Neurological disorders**: SPRY2's role in regulating cell migration and differentiation suggests that its dysregulation may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SPRY2 is a critical regulator of various cellular processes, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the role of SPRY2 in human disease and to develop therapeutic strategies that target this gene.

Genular Protein ID: 3050276979

Symbol: SPY2_HUMAN

Name: Protein sprouty homolog 2

UniProtKB Accession Codes:

O43597 B2R9J9 Q5T6Z7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 43 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9458049

Title: Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

PubMed ID: 9458049

DOI: 10.1016/s0092-8674(00)80919-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10887178

Title: Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.

PubMed ID: 10887178

DOI: 10.1074/jbc.m002156200

PubMed ID: 16877379

Title: A functional interaction between sprouty proteins and caveolin-1.

PubMed ID: 16877379

DOI: 10.1074/jbc.m603921200

PubMed ID: 12717443

Title: Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

PubMed ID: 12717443

DOI: 10.1038/ncb978

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21288888

Title: Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate.

PubMed ID: 21288888

DOI: 10.1093/jb/mvr017

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29408807

Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

PubMed ID: 29408807

DOI: 10.1172/jci97350

PubMed ID: 25782674

Title: A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy.

PubMed ID: 25782674

DOI: 10.1038/ejhg.2015.52

Sequence Information:

  • Length: 315
  • Mass: 34688
  • Checksum: 8CC6256929D91A7E
  • Sequence:
    • MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS 
STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED 
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 
CKVPTVPPRN FEKPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.