Details for: STAM2

Gene ID: 10254

Symbol: STAM2

Ensembl ID: ENSG00000115145

Description: signal transducing adaptor molecule 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.72
    Marker Score: 3,009
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.59
    Marker Score: 6,473
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91,473
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.47
    Marker Score: 15,183
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.45
    Marker Score: 13,744
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.42
    Marker Score: 12,189
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29,493
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1,561
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.34
    Marker Score: 5,189
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.34
    Marker Score: 26,647
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.33
    Marker Score: 12,478
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.32
    Marker Score: 10,150
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.32
    Marker Score: 48,628
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.31
    Marker Score: 2,029
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.29
    Marker Score: 19,276
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.25
    Marker Score: 47,448
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.25
    Marker Score: 730
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.16
    Marker Score: 3,979
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.14
    Marker Score: 2,498
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.11
    Marker Score: 4,581
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.09
    Marker Score: 9,452
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.07
    Marker Score: 1,133
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.06
    Marker Score: 2,034
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2,344
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1
    Marker Score: 2,679
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,714
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1
    Marker Score: 1,101
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,939
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,410
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.98
    Marker Score: 753
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.96
    Marker Score: 827
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.96
    Marker Score: 1,030
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.95
    Marker Score: 962
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.94
    Marker Score: 749
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.93
    Marker Score: 273
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.93
    Marker Score: 491
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 979
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.93
    Marker Score: 31,249
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.92
    Marker Score: 629
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.92
    Marker Score: 1,350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 423
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.87
    Marker Score: 831
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.87
    Marker Score: 3,607
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.86
    Marker Score: 395
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,908
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.86
    Marker Score: 2,108
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.86
    Marker Score: 247
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.85
    Marker Score: 568
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1,220
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 1,006
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.83
    Marker Score: 414
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.83
    Marker Score: 3,479
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.81
    Marker Score: 1,151
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.81
    Marker Score: 1,003
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.81
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.8
    Marker Score: 480
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.8
    Marker Score: 253
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.8
    Marker Score: 335
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.8
    Marker Score: 994
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.8
    Marker Score: 554
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4,775
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.79
    Marker Score: 1,996
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1,830
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.76
    Marker Score: 1,454
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.76
    Marker Score: 754
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 370
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.75
    Marker Score: 1,792
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.74
    Marker Score: 214
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.74
    Marker Score: 641
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,093
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.74
    Marker Score: 11,834
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.74
    Marker Score: 653
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.72
    Marker Score: 12,848
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 351
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.72
    Marker Score: 166
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.72
    Marker Score: 3,311
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 742
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.71
    Marker Score: 1,183
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.71
    Marker Score: 143
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.71
    Marker Score: 412
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.7
    Marker Score: 408
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.7
    Marker Score: 390
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 895
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 219
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.68
    Marker Score: 2,932
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 212
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 621
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.67
    Marker Score: 249

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STAM2 is a cytoplasmic protein that belongs to the STAM family of adaptor molecules. It is characterized by its ability to bind to various signaling proteins, including growth factor receptors, and to interact with cytoskeletal components. STAM2 is highly expressed in germ cells, neurons, and astrocytes, suggesting its involvement in developmental and neuronal functions. **Pathways and Functions:** STAM2 is involved in numerous signaling pathways, including: 1. **Clathrin-mediated endocytosis:** STAM2 regulates the uptake of proteins and lipids from the plasma membrane into endosomes. 2. **Cargo recognition for clathrin-mediated endocytosis:** STAM2 interacts with clathrin and other proteins to recognize and internalize specific cargo molecules. 3. **Infectious disease:** STAM2 is essential for the entry of Listeria monocytogenes into host cells, highlighting its role in immune evasion. 4. **Metabolic regulation:** STAM2 modulates protein transport to the vacuole via the multivesicular body sorting pathway. 5. **Neurological functions:** STAM2 is expressed in neurons and astrocytes, suggesting its involvement in neuronal development, function, and maintenance. **Clinical Significance:** STAM2 has significant implications in various diseases, including: 1. **Infectious diseases:** STAM2's role in Listeria monocytogenes entry into host cells makes it a potential target for therapeutic interventions. 2. **Cancer:** STAM2's involvement in signaling pathways and protein transport suggests its potential as a prognostic biomarker or therapeutic target. 3. **Neurological disorders:** STAM2's expression in neurons and astrocytes implies its involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, STAM2 is a multifaceted gene that plays a crucial role in various cellular processes, including signaling pathways, endocytosis, and protein transport. Its clinical significance extends to infectious diseases, cancer, and neurological disorders, highlighting the need for further research into the molecular mechanisms underlying STAM2's functions. **Recommendations:** 1. **Investigate STAM2's role in neurodegenerative diseases:** Further studies are needed to elucidate STAM2's involvement in Alzheimer's and Parkinson's disease. 2. **Explore STAM2 as a therapeutic target:** Targeting STAM2's signaling pathways or protein transport functions may provide novel therapeutic opportunities for infectious diseases and cancer. 3. **Analyze STAM2's expression in cancer:** Further studies are required to determine STAM2's prognostic value and potential as a therapeutic target in cancer. By continuing to unravel the molecular mechanisms underlying STAM2's functions, we can gain a deeper understanding of its clinical significance and develop novel therapeutic strategies for various diseases.

Genular Protein ID: 1836505102

Symbol: STAM2_HUMAN

Name: Signal transducing adapter molecule 2

UniProtKB Accession Codes:

O75886 A8K8A0 D3DPA1 Q7LDQ0 Q9UF58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10899310

Title: STAM2, a new member of the STAM family, binding to the Janus kinases.

PubMed ID: 10899310

DOI: 10.1016/s0014-5793(00)01760-9

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12551915

Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

PubMed ID: 12551915

DOI: 10.1074/jbc.m210843200

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15882967

Title: The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

PubMed ID: 15882967

DOI: 10.1016/j.bbrc.2005.04.016

PubMed ID: 15509564

Title: Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.

PubMed ID: 15509564

DOI: 10.1074/jbc.m410384200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 525
  • Mass: 58164
  • Checksum: 408D484544DD9403
  • Sequence:
    • MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI MKRVNHKVPH 
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF 
QKDPQFSLIS ATIKSMKEEG ITFPPAGSQT VSAAAKNGTS SNKNKEDEDI AKAIELSLQE 
QKQQHTETKS LYPSSEIQLN NKVARKVRAL YDFEAVEDNE LTFKHGEIII VLDDSDANWW 
KGENHRGIGL FPSNFVTTNL NIETEAAAVD KLNVIDDDVE EIKKSEPEPV YIDEDKMDRA 
LQVLQSIDPT DSKPDSQDLL DLEDICQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALEL 
YNKLVNEAPV YSVYSKLHPP AHYPPASSGV PMQTYPVQSH GGNYMGQSIH QVTVAQSYSL 
GPDQIGPLRS LPPNVNSSVT AQPAQTSYLS TGQDTVSNPT YMNQNSNLQS ATGTTAYTQQ 
MGMSVDMSSY QNTTSNLPQL AGFPVTVPAH PVAQQHTNYH QQPLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.