CDKN1A | ENSG00000124762 | NCBI 1026

Details for: CDKN1A

Gene ID: 1026

Symbol: CDKN1A

Ensembl ID: ENSG00000124762

Description: cyclin dependent kinase inhibitor 1A

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular senescence
(R-HSA-2559583)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Flt3 signaling in disease
(R-HSA-9682385)
Formation of senescence-associated heterochromatin foci (sahf)
(R-HSA-2559584)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
G1 phase
(R-HSA-69236)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Metabolism of proteins
(R-HSA-392499)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Neddylation
(R-HSA-8951664)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates cdkn1a transcription
(R-HSA-8941855)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
Tfap2 (ap-2) family regulates transcription of cell cycle factors
(R-HSA-8866911)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional activation of cell cycle inhibitor p21
(R-HSA-69895)
Transcriptional activation of p53 responsive genes
(R-HSA-69560)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Cyclin-dependent protein kinase activating kinase activity
(GO:0019912)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin binding
(GO:0030332)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
(GO:0006978)
G1/s transition of mitotic cell cycle
(GO:0000082)
Heart development
(GO:0007507)
In utero embryonic development
(GO:0001701)
Metal ion binding
(GO:0046872)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Molecular function activator activity
(GO:0140677)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of protein phosphorylation
(GO:0001933)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein sequestering activity
(GO:0140311)
Ras protein signal transduction
(GO:0007265)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Response to organonitrogen compound
(GO:0010243)
Response to toxic substance
(GO:0009636)
Response to x-ray
(GO:0010165)
Response to xenobiotic stimulus
(GO:0009410)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Cyclin-dependent kinase inhibitor 1

Genular Protein ID: 1346275036

Symbol: CDN1A_HUMAN

Name: Cyclin-dependent kinase inhibitor 1

UniProtKB Accession Codes:

P38936 Q14010 Q6FI05 Q9BUT4

Database IDs:

Citations:

PubMed ID: 8242751

Title: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

PubMed ID: 8242751

DOI: 10.1016/0092-8674(93)90499-g

PubMed ID: 8242752

Title: WAF1, a potential mediator of p53 tumor suppression.

PubMed ID: 8242752

DOI: 10.1016/0092-8674(93)90500-p

PubMed ID: 8259214

Title: p21 is a universal inhibitor of cyclin kinases.

PubMed ID: 8259214

DOI: 10.1038/366701a0

PubMed ID: 7753561

Title: The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.

PubMed ID: 7753561

PubMed ID: 8125163

Title: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

PubMed ID: 8125163

DOI: 10.1006/excr.1994.1063

PubMed ID: 7655464

Title: Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.

PubMed ID: 7655464

DOI: 10.1093/hmg/4.6.1089

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15574338

Title: N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

PubMed ID: 15574338

DOI: 10.1016/j.molcel.2004.11.011

PubMed ID: 10753973

Title: Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding.

PubMed ID: 10753973

DOI: 10.1074/jbc.275.15.11529

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 11350925

Title: A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.

PubMed ID: 11350925

DOI: 10.1093/emboj/20.10.2367

PubMed ID: 11595739

Title: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

PubMed ID: 11595739

DOI: 10.1074/jbc.m106990200

PubMed ID: 11463845

Title: Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.

PubMed ID: 11463845

DOI: 10.1128/mcb.21.16.5644-5657.2001

PubMed ID: 12431783

Title: Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

PubMed ID: 12431783

DOI: 10.1016/s0167-4889(02)00347-6

PubMed ID: 15226418

Title: N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.

PubMed ID: 15226418

DOI: 10.1128/mcb.24.14.6140-6150.2004

PubMed ID: 16982699

Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

PubMed ID: 16982699

DOI: 10.1128/mcb.00201-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18794347

Title: PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

PubMed ID: 18794347

DOI: 10.1101/gad.1676108

PubMed ID: 18794348

Title: The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

PubMed ID: 18794348

DOI: 10.1101/gad.1703708

PubMed ID: 18703516

Title: CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

PubMed ID: 18703516

DOI: 10.1074/jbc.m806045200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19445729

Title: A dual role of Cdk2 in DNA damage response.

PubMed ID: 19445729

DOI: 10.1186/1747-1028-4-9

PubMed ID: 19536131

Title: Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.

PubMed ID: 19536131

DOI: 10.1038/emboj.2009.164

PubMed ID: 19332548

Title: Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells.

PubMed ID: 19332548

DOI: 10.1074/jbc.m808810200

PubMed ID: 20307683

Title: Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.

PubMed ID: 20307683

DOI: 10.1016/j.biocel.2010.03.012

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23213251

Title: TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.

PubMed ID: 23213251

DOI: 10.1073/pnas.1214156110

PubMed ID: 23645206

Title: ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).

PubMed ID: 23645206

DOI: 10.1038/cdd.2013.33

PubMed ID: 25329316

Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PubMed ID: 25329316

DOI: 10.1371/journal.pgen.1004721

PubMed ID: 8861913

Title: Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.

PubMed ID: 8861913

DOI: 10.1016/s0092-8674(00)81347-1

Sequence Information:

Length: 164
Mass: 18119
Checksum: 98D1E7C519ADFCA9
Sequence:

MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE 
GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV 
PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN1A

Associated with

Other Information

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. PubMed ID: 8242751

WAF1, a potential mediator of p53 tumor suppression. PubMed ID: 8242752

p21 is a universal inhibitor of cyclin kinases. PubMed ID: 8259214

The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. PubMed ID: 7753561

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. PubMed ID: 8125163

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer. PubMed ID: 7655464

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1). PubMed ID: 15574338

Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. PubMed ID: 10753973

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. PubMed ID: 11350925

Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. PubMed ID: 11595739

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. PubMed ID: 11463845

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. PubMed ID: 12431783

N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. PubMed ID: 15226418

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. PubMed ID: 16982699

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. PubMed ID: 18794347

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. PubMed ID: 18794348

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. PubMed ID: 18703516

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

A dual role of Cdk2 in DNA damage response. PubMed ID: 19445729

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. PubMed ID: 19536131

Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. PubMed ID: 19332548

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells. PubMed ID: 20307683

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. PubMed ID: 23213251

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). PubMed ID: 23645206

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PubMed ID: 25329316

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. PubMed ID: 8861913