CDKN1A | ENSG00000124762 | NCBI 1026

Details for: CDKN1A

Gene ID: 1026

Symbol: CDKN1A

Ensembl ID: ENSG00000124762

Description: cyclin dependent kinase inhibitor 1A

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular senescence
(R-HSA-2559583)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Flt3 signaling in disease
(R-HSA-9682385)
Formation of senescence-associated heterochromatin foci (sahf)
(R-HSA-2559584)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
G1 phase
(R-HSA-69236)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Metabolism of proteins
(R-HSA-392499)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Neddylation
(R-HSA-8951664)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Regulation of mitf-m-dependent genes involved in cell cycle and proliferation
(R-HSA-9825892)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates cdkn1a transcription
(R-HSA-8941855)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
Tfap2 (ap-2) family regulates transcription of cell cycle factors
(R-HSA-8866911)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional activation of cell cycle inhibitor p21
(R-HSA-69895)
Transcriptional activation of p53 responsive genes
(R-HSA-69560)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Cyclin-dependent protein kinase activating kinase activity
(GO:0019912)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin binding
(GO:0030332)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
(GO:0006978)
G1/s transition of mitotic cell cycle
(GO:0000082)
Heart development
(GO:0007507)
In utero embryonic development
(GO:0001701)
Metal ion binding
(GO:0046872)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Molecular function activator activity
(GO:0140677)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of protein phosphorylation
(GO:0001933)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein sequestering activity
(GO:0140311)
Protein serine/threonine kinase binding
(GO:0120283)
Ras protein signal transduction
(GO:0007265)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 364.6528
Cell Significance Index: -56.7200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 223.4634
Cell Significance Index: -56.6800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 142.6031
Cell Significance Index: -58.7500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 104.6686
Cell Significance Index: -53.8400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 81.7186
Cell Significance Index: -54.8400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 46.0033
Cell Significance Index: -56.7200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.0141
Cell Significance Index: -53.6200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.5334
Cell Significance Index: -47.7100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.3764
Cell Significance Index: -56.7300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 13.6351
Cell Significance Index: 240.9500
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 7.9129
Cell Significance Index: 56.8300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.3785
Cell Significance Index: -13.9600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.7048
Cell Significance Index: 128.0600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.6498
Cell Significance Index: 137.6500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.5239
Cell Significance Index: 72.3500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.4831
Cell Significance Index: 45.9000
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 1.9802
Cell Significance Index: 34.0200
Cell Name: odontoblast (CL0000060)
Fold Change: 1.8724
Cell Significance Index: 240.0300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.8417
Cell Significance Index: 49.3500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.8272
Cell Significance Index: 224.6700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7113
Cell Significance Index: 127.5400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 1.5637
Cell Significance Index: 976.4900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.5075
Cell Significance Index: 271.7500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.1724
Cell Significance Index: 7.2200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 1.0961
Cell Significance Index: 125.1200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9744
Cell Significance Index: 96.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.9396
Cell Significance Index: 44.1600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9318
Cell Significance Index: 508.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7791
Cell Significance Index: 148.2700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.7491
Cell Significance Index: 11.5900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7279
Cell Significance Index: 94.0400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7228
Cell Significance Index: 32.7600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6567
Cell Significance Index: 71.4300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6005
Cell Significance Index: 5.5300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5617
Cell Significance Index: 26.1900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5492
Cell Significance Index: 242.8000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5452
Cell Significance Index: 35.1800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4196
Cell Significance Index: 378.8900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4082
Cell Significance Index: 56.0600
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.2881
Cell Significance Index: 1.3300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1827
Cell Significance Index: 36.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1590
Cell Significance Index: 25.8600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0667
Cell Significance Index: 11.3900
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.0639
Cell Significance Index: 0.1900
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0442
Cell Significance Index: 4.5200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0079
Cell Significance Index: 0.0900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0007
Cell Significance Index: -0.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0054
Cell Significance Index: -0.6200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0112
Cell Significance Index: -21.0600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0114
Cell Significance Index: -0.5700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0122
Cell Significance Index: -6.9000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0196
Cell Significance Index: -14.5300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0341
Cell Significance Index: -62.9000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0359
Cell Significance Index: -55.3400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0381
Cell Significance Index: -28.8500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0410
Cell Significance Index: -26.0300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0459
Cell Significance Index: -33.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0490
Cell Significance Index: -66.6400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0501
Cell Significance Index: -1.4700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0756
Cell Significance Index: -5.3500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1057
Cell Significance Index: -4.3300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1116
Cell Significance Index: -50.6300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1273
Cell Significance Index: -26.8200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1404
Cell Significance Index: -50.3700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1502
Cell Significance Index: -2.2500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1733
Cell Significance Index: -2.3700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1824
Cell Significance Index: -52.4900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2078
Cell Significance Index: -30.2000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2420
Cell Significance Index: -48.5400
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.2698
Cell Significance Index: -1.6700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2729
Cell Significance Index: -9.5900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2813
Cell Significance Index: -32.7800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3346
Cell Significance Index: -9.3500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3453
Cell Significance Index: -40.7200
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.4042
Cell Significance Index: -4.2200
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.4113
Cell Significance Index: -1.5800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4477
Cell Significance Index: -4.6400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5287
Cell Significance Index: -11.4600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5492
Cell Significance Index: -57.1800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5769
Cell Significance Index: -45.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6729
Cell Significance Index: -51.6400
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.6922
Cell Significance Index: -4.6900
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.7060
Cell Significance Index: -10.0500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7417
Cell Significance Index: -18.5400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7517
Cell Significance Index: -16.0100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7761
Cell Significance Index: -47.5900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7904
Cell Significance Index: -25.3200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8374
Cell Significance Index: -56.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.8941
Cell Significance Index: -56.3500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.9363
Cell Significance Index: -57.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.9371
Cell Significance Index: -49.2000
Cell Name: peg cell (CL4033014)
Fold Change: -0.9380
Cell Significance Index: -21.6700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9966
Cell Significance Index: -26.2100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0798
Cell Significance Index: -28.8900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0970
Cell Significance Index: -40.2700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.1092
Cell Significance Index: -62.2400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.1926
Cell Significance Index: -34.3600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.2579
Cell Significance Index: -37.0500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2833
Cell Significance Index: -44.6000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.3457
Cell Significance Index: -34.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Cell Cycle Regulation:** CDKN1A is a potent inhibitor of cyclin-dependent kinases, which are essential for cell cycle progression. It regulates the G1/S transition by inhibiting the activity of cyclin-dependent kinases, thereby preventing the transition from the G1 phase to the S phase. 2. **Tumor Suppressor Function:** CDKN1A acts as a tumor suppressor by inhibiting the activity of cyclin-dependent kinases, which are often overactive in cancer cells. This leads to cell cycle arrest and prevents the proliferation of cancer cells. 3. **Immune Response Regulation:** CDKN1A is involved in the regulation of immune responses, particularly in the context of cancer. It has been shown to regulate the activity of immune cells, such as T cells and dendritic cells, and has been implicated in the development of cancer-related immune evasion. 4. **Cancer Association:** CDKN1A has been identified as a tumor suppressor gene in various cancers, including breast, prostate, and colon cancer. Mutations in this gene have been associated with increased cancer risk and poor prognosis. 5. **Stress Response:** CDKN1A is also involved in the regulation of cellular stress responses, particularly in the context of DNA damage. It has been shown to regulate the activity of p53, a key transcription factor involved in DNA damage response. **Pathways and Functions:** 1. **Cell Cycle Checkpoints:** CDKN1A regulates cell cycle checkpoints, particularly at the G1/S transition. It inhibits the activity of cyclin-dependent kinases, which prevents the transition from the G1 phase to the S phase. 2. **Cancer Suppression:** CDKN1A acts as a tumor suppressor by inhibiting the activity of cyclin-dependent kinases, which are often overactive in cancer cells. 3. **Immune Response Regulation:** CDKN1A regulates the activity of immune cells, such as T cells and dendritic cells, and has been implicated in the development of cancer-related immune evasion. 4. **Stress Response:** CDKN1A regulates the activity of p53, a key transcription factor involved in DNA damage response. 5. **Signaling Pathways:** CDKN1A is involved in various signaling pathways, including the PI3K/AKT pathway, the MAPK/ERK pathway, and the NF-κB pathway. **Clinical Significance:** 1. **Cancer Prognosis:** CDKN1A is a prognostic marker for various cancers, including breast, prostate, and colon cancer. Low expression of CDKN1A has been associated with poor prognosis and increased cancer risk. 2. **Immunotherapy:** CDKN1A has been identified as a potential target for immunotherapy in cancer. Its expression can be restored in cancer cells to enhance the activity of immune cells and improve cancer treatment outcomes. 3. **Cancer Treatment:** CDKN1A has been shown to be a potential therapeutic target for cancer treatment. Inhibitors of CDKN1A have been developed to restore its expression in cancer cells and enhance the activity of immune cells. 4. **Immune System Function:** CDKN1A is involved in the regulation of immune system function, particularly in the context of cancer. Its expression can be restored in immune cells to enhance their activity and improve cancer treatment outcomes. In conclusion, CDKN1A is a critical regulator of cell cycle and immune response. Its dysregulation has been implicated in various cancers and has significant clinical implications for cancer treatment and immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase inhibitor 1

Genular Protein ID: 1346275036

Symbol: CDN1A_HUMAN

Name: Cyclin-dependent kinase inhibitor 1

UniProtKB Accession Codes:

P38936 Q14010 Q6FI05 Q9BUT4

Database IDs:

Citations:

PubMed ID: 8242751

Title: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

PubMed ID: 8242751

DOI: 10.1016/0092-8674(93)90499-g

PubMed ID: 8242752

Title: WAF1, a potential mediator of p53 tumor suppression.

PubMed ID: 8242752

DOI: 10.1016/0092-8674(93)90500-p

PubMed ID: 8259214

Title: p21 is a universal inhibitor of cyclin kinases.

PubMed ID: 8259214

DOI: 10.1038/366701a0

PubMed ID: 7753561

Title: The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.

PubMed ID: 7753561

PubMed ID: 8125163

Title: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

PubMed ID: 8125163

DOI: 10.1006/excr.1994.1063

PubMed ID: 7655464

Title: Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.

PubMed ID: 7655464

DOI: 10.1093/hmg/4.6.1089

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15574338

Title: N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

PubMed ID: 15574338

DOI: 10.1016/j.molcel.2004.11.011

PubMed ID: 10753973

Title: Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding.

PubMed ID: 10753973

DOI: 10.1074/jbc.275.15.11529

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 11350925

Title: A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.

PubMed ID: 11350925

DOI: 10.1093/emboj/20.10.2367

PubMed ID: 11595739

Title: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

PubMed ID: 11595739

DOI: 10.1074/jbc.m106990200

PubMed ID: 11463845

Title: Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells.

PubMed ID: 11463845

DOI: 10.1128/mcb.21.16.5644-5657.2001

PubMed ID: 12431783

Title: Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

PubMed ID: 12431783

DOI: 10.1016/s0167-4889(02)00347-6

PubMed ID: 15226418

Title: N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.

PubMed ID: 15226418

DOI: 10.1128/mcb.24.14.6140-6150.2004

PubMed ID: 16982699

Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

PubMed ID: 16982699

DOI: 10.1128/mcb.00201-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18794347

Title: PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

PubMed ID: 18794347

DOI: 10.1101/gad.1676108

PubMed ID: 18794348

Title: The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

PubMed ID: 18794348

DOI: 10.1101/gad.1703708

PubMed ID: 18703516

Title: CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

PubMed ID: 18703516

DOI: 10.1074/jbc.m806045200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19445729

Title: A dual role of Cdk2 in DNA damage response.

PubMed ID: 19445729

DOI: 10.1186/1747-1028-4-9

PubMed ID: 19536131

Title: Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.

PubMed ID: 19536131

DOI: 10.1038/emboj.2009.164

PubMed ID: 19332548

Title: Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells.

PubMed ID: 19332548

DOI: 10.1074/jbc.m808810200

PubMed ID: 20307683

Title: Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.

PubMed ID: 20307683

DOI: 10.1016/j.biocel.2010.03.012

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23213251

Title: TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.

PubMed ID: 23213251

DOI: 10.1073/pnas.1214156110

PubMed ID: 23645206

Title: ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).

PubMed ID: 23645206

DOI: 10.1038/cdd.2013.33

PubMed ID: 25329316

Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PubMed ID: 25329316

DOI: 10.1371/journal.pgen.1004721

PubMed ID: 8861913

Title: Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.

PubMed ID: 8861913

DOI: 10.1016/s0092-8674(00)81347-1

Sequence Information:

Length: 164
Mass: 18119
Checksum: 98D1E7C519ADFCA9
Sequence:

MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE 
GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV 
PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN1A

Associated with

Cells (max top 100)

Other Information

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. PubMed ID: 8242751

WAF1, a potential mediator of p53 tumor suppression. PubMed ID: 8242752

p21 is a universal inhibitor of cyclin kinases. PubMed ID: 8259214

The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. PubMed ID: 7753561

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. PubMed ID: 8125163

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer. PubMed ID: 7655464

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1). PubMed ID: 15574338

Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. PubMed ID: 10753973

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. PubMed ID: 11350925

Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. PubMed ID: 11595739

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. PubMed ID: 11463845

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. PubMed ID: 12431783

N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. PubMed ID: 15226418

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. PubMed ID: 16982699

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. PubMed ID: 18794347

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. PubMed ID: 18794348

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. PubMed ID: 18703516

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

A dual role of Cdk2 in DNA damage response. PubMed ID: 19445729

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. PubMed ID: 19536131

Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. PubMed ID: 19332548

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells. PubMed ID: 20307683

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. PubMed ID: 23213251

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). PubMed ID: 23645206

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PubMed ID: 25329316

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. PubMed ID: 8861913