Details for: IGSF6

Gene ID: 10261

Symbol: IGSF6

Ensembl ID: ENSG00000140749

Description: immunoglobulin superfamily member 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.85
    Marker Score: 159,302
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.8
    Marker Score: 3,204
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.67
    Marker Score: 2,667
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.64
    Marker Score: 5,144
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.44
    Marker Score: 6,073
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.26
    Marker Score: 5,863
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 2.19
    Marker Score: 2,229
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.16
    Marker Score: 55,313
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.88
    Marker Score: 1,033
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.8
    Marker Score: 10,926
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.79
    Marker Score: 4,323
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.72
    Marker Score: 717
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.71
    Marker Score: 2,069
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.67
    Marker Score: 19,435
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.64
    Marker Score: 670
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.61
    Marker Score: 6,702
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,161
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.21
    Marker Score: 491
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.09
    Marker Score: 1,211
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,786
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.02
    Marker Score: 506
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.02
    Marker Score: 689
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.98
    Marker Score: 245
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.88
    Marker Score: 888
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.87
    Marker Score: 1,125
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 636
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.82
    Marker Score: 247
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.82
    Marker Score: 3,425
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.76
    Marker Score: 442
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1,153
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.61
    Marker Score: 418
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 385
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.6
    Marker Score: 207
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.6
    Marker Score: 413
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.57
    Marker Score: 158
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 348
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5
    Marker Score: 601
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.49
    Marker Score: 2,062
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.49
    Marker Score: 325
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.47
    Marker Score: 272
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.46
    Marker Score: 297
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.46
    Marker Score: 136
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.45
    Marker Score: 195
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.45
    Marker Score: 1,734
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 201
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.43
    Marker Score: 148
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 136
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.4
    Marker Score: 198
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.4
    Marker Score: 725
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.39
    Marker Score: 140
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 244
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.38
    Marker Score: 293
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.38
    Marker Score: 130
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.36
    Marker Score: 481
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.35
    Marker Score: 215
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.32
    Marker Score: 164
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.32
    Marker Score: 174
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.32
    Marker Score: 487
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.31
    Marker Score: 161
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.29
    Marker Score: 281
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.29
    Marker Score: 126
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.28
    Marker Score: 92
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.27
    Marker Score: 264
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 640
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 104
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.24
    Marker Score: 298
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 226
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1,381
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.23
    Marker Score: 244
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 88
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.21
    Marker Score: 13,210

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGSF6 is a single-copy gene located on chromosome 11q13.3 in humans. The gene spans approximately 15 kilobases and consists of 10 exons. The protein product of this gene, IGSF6, is a transmembrane receptor with a characteristic immunoglobulin-like domain. The receptor is expressed on the surface of various immune cells, including classical monocytes, lung macrophages, Kupffer cells, and dendritic cells. IGSF6 is also expressed in other tissues, such as the lung and liver, where it may play a role in the regulation of immune responses in these organs. **Pathways and Functions** IGSF6 is involved in several signaling pathways that regulate immune responses. The receptor interacts with its ligands, leading to the activation of downstream signaling molecules, such as Janus kinase (JAK) and signal transducers and activators of transcription (STAT) proteins. These signaling molecules then regulate the expression of genes involved in immune responses, including the production of cytokines and chemokines. The primary function of IGSF6 is to modulate the functions of immune cells, such as monocytes and macrophages. The receptor is involved in the regulation of cell migration, phagocytosis, and cytokine production. IGSF6 may also play a role in the regulation of immune responses in tissues, such as the lung and liver, where it may help to maintain tissue homeostasis and prevent inflammation. **Clinical Significance** Dysregulation of IGSF6 has been implicated in several autoimmune and inflammatory diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Studies have shown that IGSF6 is overexpressed in these diseases, leading to the activation of immune cells and the production of pro-inflammatory cytokines. IGSF6 has also been identified as a potential therapeutic target for the treatment of cancer. The receptor is overexpressed in several types of cancer, including lung and breast cancer, and its dysregulation has been linked to tumor progression and metastasis. In addition, IGSF6 has been shown to play a role in the regulation of immune responses in infectious diseases, such as tuberculosis and HIV. The receptor may help to modulate the functions of immune cells, such as macrophages and dendritic cells, to prevent the progression of the disease. In summary, IGSF6 is an important regulator of immune responses, and its dysregulation has been implicated in several autoimmune and inflammatory diseases, as well as cancer. Further research is needed to fully understand the role of IGSF6 in the regulation of immune responses and to develop effective therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 3010263130

Symbol: IGSF6_HUMAN

Name: Immunoglobulin superfamily member 6

UniProtKB Accession Codes:

O95976 Q8WWD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9809579

Title: CD40L activation of dendritic cells down-regulates DORA, a novel member of the immunoglobulin superfamily.

PubMed ID: 9809579

DOI: 10.1016/s0161-5890(98)00045-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11132146

Title: The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function.

PubMed ID: 11132146

DOI: 10.1007/s002510000259

PubMed ID: 12786995

Title: Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease.

PubMed ID: 12786995

DOI: 10.1046/j.1365-2370.2003.00387.x

Sequence Information:

  • Length: 241
  • Mass: 27013
  • Checksum: 1FA0637611138193
  • Sequence:
    • MGTASRSNIA RHLQTNLILF CVGAVGACTL SVTQPWYLEV DYTHEAVTIK CTFSATGCPS 
EQPTCLWFRY GAHQPENLCL DGCKSEADKF TVREALKENQ VSLTVNRVTS NDSAIYICGI 
AFPSVPEARA KQTGGGTTLV VREIKLLSKE LRSFLTALVS LLSVYVTGVC VAFILLSKSK 
SNPLRNKEIK EDSQKKKSAR RIFQEIAQEL YHKRHVETNQ QSEKDNNTYE NRRVLSNYER 
P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.