Details for: CDK2AP2

Gene ID: 10263

Symbol: CDK2AP2

Ensembl ID: ENSG00000167797

Description: cyclin dependent kinase 2 associated protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.06
    Marker Score: 1,860
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.03
    Marker Score: 2,139
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.48
    Marker Score: 4,334
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.48
    Marker Score: 3,982
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2
    Marker Score: 14,058
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.17
    Marker Score: 29,167
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.08
    Marker Score: 6,524
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.07
    Marker Score: 6,140
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.04
    Marker Score: 13,310
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.04
    Marker Score: 1,738
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.01
    Marker Score: 5,552
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.92
    Marker Score: 1,629
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.91
    Marker Score: 22,252
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.9
    Marker Score: 2,114
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.89
    Marker Score: 9,908
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.79
    Marker Score: 526
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.79
    Marker Score: 17,684
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.72
    Marker Score: 5,428
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.68
    Marker Score: 4,570
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.66
    Marker Score: 7,973
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.65
    Marker Score: 4,828
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.65
    Marker Score: 949
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.64
    Marker Score: 56,865
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.62
    Marker Score: 1,566
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.61
    Marker Score: 2,275
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.6
    Marker Score: 2,127
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.6
    Marker Score: 788
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.59
    Marker Score: 1,160
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.58
    Marker Score: 883
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.58
    Marker Score: 10,069
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.56
    Marker Score: 2,208
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.55
    Marker Score: 1,575
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.55
    Marker Score: 3,910
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.54
    Marker Score: 2,272
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.54
    Marker Score: 3,003
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.53
    Marker Score: 6,017
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.53
    Marker Score: 4,163
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.5
    Marker Score: 3,555
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.48
    Marker Score: 2,901
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.47
    Marker Score: 5,209
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.45
    Marker Score: 14,617
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,327
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.44
    Marker Score: 417
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.44
    Marker Score: 1,261
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.42
    Marker Score: 2,093
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.4
    Marker Score: 851
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.39
    Marker Score: 6,014
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.39
    Marker Score: 422
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.39
    Marker Score: 3,889
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.38
    Marker Score: 2,411
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.34
    Marker Score: 1,112
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.34
    Marker Score: 689
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.34
    Marker Score: 2,218
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.33
    Marker Score: 2,120
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.32
    Marker Score: 1,034
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.31
    Marker Score: 488
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.3
    Marker Score: 1,098
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.29
    Marker Score: 450
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.28
    Marker Score: 1,358
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.28
    Marker Score: 2,909
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.27
    Marker Score: 2,673
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.27
    Marker Score: 845
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.26
    Marker Score: 296
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.26
    Marker Score: 7,486
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.26
    Marker Score: 695
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.26
    Marker Score: 693
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.26
    Marker Score: 4,847
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.25
    Marker Score: 5,212
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.25
    Marker Score: 833
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.24
    Marker Score: 2,210
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.24
    Marker Score: 10,661
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.23
    Marker Score: 891
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.23
    Marker Score: 1,251
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.23
    Marker Score: 826
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.23
    Marker Score: 2,173
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.21
    Marker Score: 1,223
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.21
    Marker Score: 3,254
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.21
    Marker Score: 1,075
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.21
    Marker Score: 383
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.21
    Marker Score: 9,426
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.2
    Marker Score: 346
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2
    Marker Score: 287
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.2
    Marker Score: 981
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.2
    Marker Score: 516
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.19
    Marker Score: 935
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.19
    Marker Score: 2,970
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.19
    Marker Score: 4,397
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.19
    Marker Score: 818
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.19
    Marker Score: 365
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.18
    Marker Score: 652
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.18
    Marker Score: 1,480
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.18
    Marker Score: 1,051
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.18
    Marker Score: 1,414
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.17
    Marker Score: 442
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.17
    Marker Score: 1,117
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.16
    Marker Score: 2,649
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.16
    Marker Score: 64,989
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.16
    Marker Score: 8,623
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.15
    Marker Score: 356

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDK2AP2 is a protein that interacts with cyclin-dependent kinase 2 (CDK2), a key regulator of the cell cycle. The CDK2AP2-CDK2 complex is involved in the negative regulation of the G1/S transition of the mitotic cell cycle, ensuring proper cell cycle progression and preventing uncontrolled proliferation. Furthermore, CDK2AP2 is also implicated in the regulation of microtubule cytoskeleton organization, a critical aspect of cellular morphology and dynamics. **Pathways and Functions:** CDK2AP2 is involved in several key pathways, including: 1. **Negative regulation of G1/S transition of the mitotic cell cycle**: CDK2AP2 interacts with CDK2 to inhibit the transition from the G1 phase to the S phase, ensuring proper cell cycle progression. 2. **Regulation of microtubule cytoskeleton organization**: CDK2AP2 influences the organization of microtubules, which is essential for maintaining cellular morphology and dynamics. 3. **Nurd complex**: CDK2AP2 is a component of the Nurd complex, a protein complex involved in the regulation of stem cell division. 4. **Protein binding**: CDK2AP2 interacts with various proteins, including CDK2, microtubule-associated proteins, and other regulatory proteins. **Clinical Significance:** CDK2AP2 has been found to be significantly expressed in various cell types, including myeloid dendritic cells, CD14-low, CD16-positive monocytes, germ cells, pneumocytes, and malignant cells. Its dysregulation has been implicated in several diseases, including: 1. **Cancer**: CDK2AP2 is often overexpressed in malignant cells, contributing to uncontrolled cell proliferation and tumorigenesis. 2. **Autoimmune disorders**: CDK2AP2 may play a role in the regulation of immune cell function, as it is expressed in CD4-positive, alpha-beta memory T cells and tonsil germinal center B cells. 3. **Inflammatory diseases**: CDK2AP2 may contribute to the development of inflammatory diseases, such as rheumatoid arthritis, by regulating the function of immune cells. In conclusion, CDK2AP2 is a multifunctional protein that plays a critical role in regulating various cellular processes, including cell cycle progression, microtubule organization, and stem cell division. Its dysregulation has been implicated in several disease contexts, highlighting the importance of further research into the mechanisms by which CDK2AP2 exerts its effects on cellular function.

Genular Protein ID: 3555140080

Symbol: CDKA2_HUMAN

Name: Cyclin-dependent kinase 2-associated protein 2

UniProtKB Accession Codes:

O75956

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10082655

Title: Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene.

PubMed ID: 10082655

DOI: 10.1006/bbrc.1999.0148

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14985111

Title: Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R).

PubMed ID: 14985111

DOI: 10.1016/j.bbrc.2004.02.003

PubMed ID: 23781148

Title: Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation.

PubMed ID: 23781148

DOI: 10.7150/ijbs.5763

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

Sequence Information:

  • Length: 126
  • Mass: 13101
  • Checksum: D668D3FA8CE70CA5
  • Sequence:
    • MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND FGPPSMGYVQ 
AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME RLKRGIIHAR ALVRECLAET 
ERNART

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.