Details for: IRX5

Gene ID: 10265

Symbol: IRX5

Ensembl ID: ENSG00000176842

Description: iroquois homeobox 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,166
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,876
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.23
    Marker Score: 5,115
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.23
    Marker Score: 384
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18,906
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,805
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.07
    Marker Score: 2,909
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2,407
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1,990
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,348
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.93
    Marker Score: 269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9
    Marker Score: 472
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.85
    Marker Score: 1,514
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.82
    Marker Score: 862
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.81
    Marker Score: 1,119
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8
    Marker Score: 8,031
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.79
    Marker Score: 181
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.77
    Marker Score: 1,508
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.74
    Marker Score: 2,138
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 339
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.71
    Marker Score: 1,614
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.71
    Marker Score: 224
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.69
    Marker Score: 2,687
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.68
    Marker Score: 358
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.66
    Marker Score: 326
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.66
    Marker Score: 362
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.66
    Marker Score: 4,271
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.64
    Marker Score: 5,592
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.63
    Marker Score: 684
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.58
    Marker Score: 269
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 183
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.56
    Marker Score: 2,958
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.54
    Marker Score: 673
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 324
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.53
    Marker Score: 220
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.51
    Marker Score: 820
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5
    Marker Score: 1,945
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.5
    Marker Score: 430
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 210
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 207
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.45
    Marker Score: 2,868
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.45
    Marker Score: 298
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 118
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.42
    Marker Score: 265
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.41
    Marker Score: 1,408
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.4
    Marker Score: 285
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 229
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.39
    Marker Score: 176
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 250
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.37
    Marker Score: 379
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.37
    Marker Score: 696
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.37
    Marker Score: 833
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.36
    Marker Score: 530
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 332
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.34
    Marker Score: 176
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.34
    Marker Score: 190
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.33
    Marker Score: 121
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.33
    Marker Score: 151
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.33
    Marker Score: 84
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 681
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.32
    Marker Score: 1,002
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.32
    Marker Score: 4,303
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.32
    Marker Score: 118
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.31
    Marker Score: 1,544
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.31
    Marker Score: 1,305
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.31
    Marker Score: 3,157
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.31
    Marker Score: 363
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.3
    Marker Score: 325
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.29
    Marker Score: 6,495
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.29
    Marker Score: 156
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.28
    Marker Score: 192
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.28
    Marker Score: 104
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.28
    Marker Score: 533
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 160

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** IRX5 is widely expressed in various tissues and organs, including the nervous system, epithelial cells, and organs such as the kidney, heart, and colon. 2. **Conserved Domain:** IRX5 contains a conserved Iroquois homeobox domain, which is essential for its function as a transcription factor. 3. **Transcriptional Regulation:** IRX5 regulates the expression of target genes through interaction with RNA polymerase II and other transcription factors. 4. **Cellular Localization:** IRX5 is primarily localized in the nucleus, where it regulates gene expression and transcription. **Pathways and Functions:** 1. **Cell Development and Differentiation:** IRX5 plays a critical role in the regulation of cell development and differentiation, particularly in the nervous system and epithelial tissues. 2. **Morphogenesis:** IRX5 is involved in the morphogenesis of various tissues and organs, including the development of the cranial skeleton and gonads. 3. **Neuron Differentiation:** IRX5 is essential for the differentiation of GABAergic interneurons in the cerebral cortex. 4. **Gene Regulation:** IRX5 regulates the expression of target genes through interaction with RNA polymerase II and other transcription factors. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** IRX5 has been implicated in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, where it is thought to play a role in the regulation of neuronal development and function. 2. **Cancer:** IRX5 has been found to be overexpressed in certain types of cancer, including colon cancer, where it is thought to contribute to tumorigenesis and cancer progression. 3. **Cardiovascular Disease:** IRX5 has been implicated in cardiovascular disease, where it is thought to play a role in the regulation of cardiac development and function. 4. **Neurodegenerative Diseases:** IRX5 has been found to be reduced in certain neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it is thought to contribute to disease progression. In conclusion, the IRX5 gene plays a critical role in the regulation of cell development, differentiation, and morphogenesis, and has significant implications for human health and disease. Further research is needed to fully elucidate the functions of IRX5 and its role in various diseases.

Genular Protein ID: 3515416834

Symbol: IRX5_HUMAN

Name: Iroquois-class homeodomain protein IRX-5

UniProtKB Accession Codes:

P78411 H0YMS7 P78416 Q7Z2E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10370142

Title: Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.

PubMed ID: 10370142

DOI: 10.1007/s004410051316

PubMed ID: 18519790

Title: The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.

PubMed ID: 18519790

DOI: 10.1158/1078-0432.ccr-07-4649

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 22581230

Title: Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.

PubMed ID: 22581230

DOI: 10.1038/ng.2259

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 483
  • Mass: 50361
  • Checksum: 12E9397924EB5E6E
  • Sequence:
    • MSYPQGYLYQ PSASLALYSC PAYSTSVISG PRTDELGRSS SGSAFSPYAG STAFTAPSPG 
YNSHLQYGAD PAAAAAAAFS SYVGSPYDHT PGMAGSLGYH PYAAPLGSYP YGDPAYRKNA 
TRDATATLKA WLNEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR LKKENKMTWT 
PRNRSEDEEE EENIDLEKND EDEPQKPEDK GDPEGPEAGG AEQKAASGCE RLQGPPTPAG 
KETEGSLSDS DFKEPPSEGR LDALQGPPRT GGPSPAGPAA ARLAEDPAPH YPAGAPAPGP 
HPAAGEVPPG PGGPSVIHSP PPPPPPAVLA KPKLWSLAEI ATSSDKVKDG GGGNEGSPCP 
PCPGPIAGQA LGGSRASPAP APSRSPSAQC PFPGGTVLSR PLYYTAPFYP GYTNYGSFGH 
LHGHPGPGPG PTTGPGSHFN GLNQTVLNRA DALAKDPKML RSQSQLDLCK DSPYELKKGM 
SDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.