Details for: RAMP2

Gene ID: 10266

Symbol: RAMP2

Ensembl ID: ENSG00000131477

Description: receptor activity modifying protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.46
    Marker Score: 3,084
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.41
    Marker Score: 13,747
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.63
    Marker Score: 6,707
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.98
    Marker Score: 3,429
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.75
    Marker Score: 32,921
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.38
    Marker Score: 4,855
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.18
    Marker Score: 4,622
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.14
    Marker Score: 6,278
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.99
    Marker Score: 695
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.65
    Marker Score: 2,498
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.21
    Marker Score: 509
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.16
    Marker Score: 2,177
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.11
    Marker Score: 512
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.09
    Marker Score: 27,536
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.06
    Marker Score: 523
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.04
    Marker Score: 3,452
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1,972
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.86
    Marker Score: 12,083
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.77
    Marker Score: 376
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.73
    Marker Score: 1,562
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.72
    Marker Score: 714
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.7
    Marker Score: 2,449
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.64
    Marker Score: 7,066
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.62
    Marker Score: 2,500
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.6
    Marker Score: 394
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.59
    Marker Score: 1,790
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.59
    Marker Score: 617
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,152
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.5
    Marker Score: 3,532
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.49
    Marker Score: 359
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,580
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.46
    Marker Score: 340
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.45
    Marker Score: 465
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.41
    Marker Score: 1,265
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.37
    Marker Score: 476
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.36
    Marker Score: 811
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.35
    Marker Score: 1,450
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.2
    Marker Score: 405
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.19
    Marker Score: 316
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.18
    Marker Score: 1,479
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,782
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2,153
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.13
    Marker Score: 12,754
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.1
    Marker Score: 241
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.07
    Marker Score: 668
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.05
    Marker Score: 1,112
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,760
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.03
    Marker Score: 296
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.02
    Marker Score: 561
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,780
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,004
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.97
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.96
    Marker Score: 818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.85
    Marker Score: 506
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.82
    Marker Score: 2,024
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.82
    Marker Score: 387
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.8
    Marker Score: 2,190
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 864
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.77
    Marker Score: 216
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.75
    Marker Score: 185
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.74
    Marker Score: 359
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11,443
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.73
    Marker Score: 1,237
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.72
    Marker Score: 301
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.71
    Marker Score: 196
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 689
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.71
    Marker Score: 469
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1,431
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.68
    Marker Score: 390
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.67
    Marker Score: 2,568
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.66
    Marker Score: 148
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.64
    Marker Score: 1,395
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3,659
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.6
    Marker Score: 721
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.59
    Marker Score: 150
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.59
    Marker Score: 215
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.59
    Marker Score: 1,230
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.59
    Marker Score: 166
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.58
    Marker Score: 235
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.58
    Marker Score: 353
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.56
    Marker Score: 1,469
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.56
    Marker Score: 131
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 231
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.54
    Marker Score: 637

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAMP2 is a small protein that modifies the activity of GPCRs by binding to specific receptors, such as adrenomedullin receptors. This binding enhances the signaling efficiency of these receptors, leading to the activation of various downstream pathways. RAMP2 is characterized by its ability to regulate blood pressure, angiogenesis, and vasculogenesis. Its expression is widespread, with significant presence in endothelial cells, which are essential for vascular development and function. **Pathways and Functions:** RAMP2 modulates the activity of various GPCRs, including adrenomedullin receptors, calcitonin-like ligand receptors, and class b/2 (secretin family receptors). These receptors are involved in regulating blood pressure, angiogenesis, and vasculogenesis. RAMP2 also interacts with other proteins, such as clathrin-coated pits, which are involved in receptor internalization and signal transduction. The unique pathways and functions of RAMP2 include: * Adenylate cyclase-activating GPCR signaling pathway: RAMP2 enhances the signaling efficiency of adrenomedullin receptors, leading to the activation of adenylate cyclase and the production of cyclic AMP. * Angiogenesis: RAMP2 promotes angiogenesis by regulating the activity of adrenomedullin receptors, which are involved in the formation of new blood vessels. * Vasculogenesis: RAMP2 plays a crucial role in the development of new blood vessels by regulating the activity of calcitonin-like ligand receptors. * Regulation of blood pressure: RAMP2 modulates the activity of adrenomedullin receptors, which are involved in regulating blood pressure. **Clinical Significance:** RAMP2 has significant clinical implications in various diseases, including: * Hypertension: RAMP2 plays a crucial role in regulating blood pressure, and dysregulation of RAMP2 has been implicated in the development of hypertension. * Angiogenesis-related disorders: RAMP2 promotes angiogenesis, and dysregulation of RAMP2 has been implicated in the development of angiogenesis-related disorders, such as cancer and atherosclerosis. * Vasculogenesis-related disorders: RAMP2 plays a crucial role in the development of new blood vessels, and dysregulation of RAMP2 has been implicated in the development of vasculogenesis-related disorders, such as vascular aneurysms and arteriovenous malformations. In conclusion, RAMP2 is a critical gene that plays a pivotal role in regulating immune responses, vascular development, and angiogenesis. Its unique characteristics, pathways, and functions make it an essential component in understanding the intricate mechanisms of immune regulation and vascular development. Further research is necessary to fully elucidate the clinical significance of RAMP2 and its potential therapeutic applications.

Genular Protein ID: 2306208764

Symbol: RAMP2_HUMAN

Name: Receptor activity-modifying protein 2

UniProtKB Accession Codes:

O60895 A7L9S6 K7EMD3 Q8N1F2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 5 EMDB 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9620797

Title: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

PubMed ID: 9620797

DOI: 10.1038/30666

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 30115739

Title: hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.

PubMed ID: 30115739

DOI: 10.1084/jem.20180528

PubMed ID: 22102369

Title: Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.

PubMed ID: 22102369

DOI: 10.1002/pro.2003

Sequence Information:

  • Length: 175
  • Mass: 19608
  • Checksum: AF69A9A461EFFCA3
  • Sequence:
    • MASLRVERAG GPRLPRTRVG RPAALRLLLL LGAVLNPHEA LAQPLPTTGT PGSEGGTVKN 
YETAVQFCWN HYKDQMDPIE KDWCDWAMIS RPYSTLRDCL EHFAELFDLG FPNPLAERII 
FETHQIHFAN CSLVQPTFSD PPEDVLLAMI IAPICLIPFL ITLVVWRSKD SEAQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.