Details for: RAMP1

Gene ID: 10267

Symbol: RAMP1

Ensembl ID: ENSG00000132329

Description: receptor activity modifying protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.61
    Marker Score: 7,302
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.72
    Marker Score: 7,851
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.09
    Marker Score: 34,748
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.95
    Marker Score: 12,717
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.39
    Marker Score: 4,491
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.29
    Marker Score: 48,857
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.25
    Marker Score: 850
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.15
    Marker Score: 48,004
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.07
    Marker Score: 2,323
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.89
    Marker Score: 1,958
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.88
    Marker Score: 787
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.86
    Marker Score: 1,102
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.81
    Marker Score: 3,964
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.78
    Marker Score: 1,867
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.76
    Marker Score: 499
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.64
    Marker Score: 1,077
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.61
    Marker Score: 607
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.58
    Marker Score: 812
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.57
    Marker Score: 21,138
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,265
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.46
    Marker Score: 6,060
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2,241
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.41
    Marker Score: 889
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.41
    Marker Score: 487
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.39
    Marker Score: 811
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.35
    Marker Score: 888
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20,684
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.32
    Marker Score: 50,036
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.27
    Marker Score: 899
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.21
    Marker Score: 301
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.2
    Marker Score: 395
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.2
    Marker Score: 290
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.19
    Marker Score: 496
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.19
    Marker Score: 43,803
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.17
    Marker Score: 342
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.15
    Marker Score: 369
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.15
    Marker Score: 2,697
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.14
    Marker Score: 284
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2,159
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.13
    Marker Score: 284
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.13
    Marker Score: 1,394
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.1
    Marker Score: 949
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.08
    Marker Score: 536
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9,376
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.07
    Marker Score: 2,420
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.06
    Marker Score: 3,781
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.06
    Marker Score: 10,001
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.02
    Marker Score: 3,955
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.01
    Marker Score: 1,423
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7,715
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,005
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.98
    Marker Score: 680
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.97
    Marker Score: 2,300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.97
    Marker Score: 277
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.96
    Marker Score: 316
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.96
    Marker Score: 1,824
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.95
    Marker Score: 806
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.94
    Marker Score: 935
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1,521
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,340
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.93
    Marker Score: 236
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.92
    Marker Score: 1,143
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.91
    Marker Score: 13,679
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.91
    Marker Score: 287
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.9
    Marker Score: 4,756
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9
    Marker Score: 30,623
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.9
    Marker Score: 296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.89
    Marker Score: 226
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.88
    Marker Score: 1,701
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.88
    Marker Score: 483
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.86
    Marker Score: 1,438
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.84
    Marker Score: 1,035
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 51,260
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.82
    Marker Score: 1,426
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.81
    Marker Score: 745
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.81
    Marker Score: 769
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.8
    Marker Score: 180
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.8
    Marker Score: 247
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.78
    Marker Score: 1,078
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.78
    Marker Score: 557
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.77
    Marker Score: 742
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.77
    Marker Score: 432
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.76
    Marker Score: 194
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.75
    Marker Score: 2,191
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.75
    Marker Score: 9,882
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.74
    Marker Score: 303
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.74
    Marker Score: 3,566
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.73
    Marker Score: 602
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.73
    Marker Score: 532

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAMP1 is a small, membrane-anchored protein that belongs to the RAMP family. It is characterized by its ability to modulate the activity of specific GPCRs, particularly those belonging to classes B/2 (secretin family receptors). RAMP1 is expressed in various tissues, including the pancreas, ovary, and brain, where it plays a crucial role in regulating hormone signaling and calcium homeostasis. The protein is highly conserved across species, suggesting its evolutionary importance in maintaining homeostasis. **Pathways and Functions:** RAMP1 modulates GPCR signaling through its interaction with specific ligands, leading to the activation or inhibition of downstream signaling events. The protein's primary functions include: 1. **Enhancing GPCR signaling:** RAMP1 binds to specific GPCR ligands, enhancing the activation of downstream signaling pathways, including adenylate cyclase-activating GPCR signaling. 2. **Regulating calcium homeostasis:** RAMP1 interacts with calcitonin gene-related peptide (CGRP) receptors, modulating calcium ion transport and homeostasis in various tissues. 3. **Modulating protein glycosylation:** RAMP1 influences the glycosylation of surface proteins, affecting their trafficking and function. 4. **Regulating GPCR internalization:** RAMP1 modulates the internalization of GPCRs, influencing their signaling and trafficking. **Clinical Significance:** RAMP1's involvement in various physiological processes has significant implications for understanding the pathophysiology of diseases. Some potential clinical applications of RAMP1 include: 1. **Neurological disorders:** RAMP1's role in modulating CGRP signaling may be relevant to conditions such as migraines, fibromyalgia, and Alzheimer's disease. 2. **Cardiovascular function:** RAMP1's influence on calcium homeostasis and GPCR signaling may be relevant to cardiovascular diseases, including hypertension and atherosclerosis. 3. **Immune responses:** RAMP1's involvement in GPCR signaling may be relevant to immune system dysregulation, including autoimmune diseases and cancer. 4. **Pancreatic function:** RAMP1's role in regulating pancreatic function and hormone signaling may be relevant to pancreatic disorders, including diabetes and pancreatitis. In conclusion, RAMP1 is a crucial component of the GPCR signaling pathway, modulating various physiological processes, including hormone signaling, calcium homeostasis, and cell surface protein transport. Further research on RAMP1's role in disease pathophysiology and its potential therapeutic applications will continue to uncover its significance in human health and disease.

Genular Protein ID: 1882490416

Symbol: RAMP1_HUMAN

Name: Receptor activity-modifying protein 1

UniProtKB Accession Codes:

O60894 Q6FGS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 6 EMDB 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 20 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9620797

Title: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

PubMed ID: 9620797

DOI: 10.1038/30666

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18725456

Title: Crystal structure of the human receptor activity-modifying protein 1 extracellular domain.

PubMed ID: 18725456

DOI: 10.1110/ps.036012.108

PubMed ID: 20826335

Title: Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

PubMed ID: 20826335

DOI: 10.1016/j.str.2010.05.014

Sequence Information:

  • Length: 148
  • Mass: 16988
  • Checksum: 8530DD590BAEBE5C
  • Sequence:
    • MARALCRLPR RGLWLLLAHH LFMTTACQEA NYGALLRELC LTQFQVDMEA VGETLWCDWG 
RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY FRSCPISGRA VRDPPGSILY 
PFIVVPITVT LLVTALVVWQ SKRTEGIV

Genular Protein ID: 3591749565

Symbol: E9PC20_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PC20

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 4 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 5 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 126
  • Mass: 14362
  • Checksum: 4D740F45A5D293F4
  • Sequence:
    • MTTACQEANY GALLRELCLT QFQVDMEAVG ETLWCDWGRT IRSYRELADC TWHMAEKLGC 
FWPNAEVDRF FLAVHGRYFR SCPISGRAVR DPPGSILYPF IVVPITVTLL VTALVVWQSK 
RTEGIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.