Details for: RAMP3

Gene ID: 10268

Symbol: RAMP3

Ensembl ID: ENSG00000122679

Description: receptor activity modifying protein 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.62
    Marker Score: 11,739
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.49
    Marker Score: 5,053
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.67
    Marker Score: 3,882
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.55
    Marker Score: 4,322
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.43
    Marker Score: 565
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.11
    Marker Score: 2,264
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.91
    Marker Score: 407
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.79
    Marker Score: 1,540
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.74
    Marker Score: 1,750
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.73
    Marker Score: 3,462
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.56
    Marker Score: 342
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.51
    Marker Score: 364
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,053
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.46
    Marker Score: 1,323
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.42
    Marker Score: 361
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.38
    Marker Score: 1,237
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2,565
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.16
    Marker Score: 307
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.1
    Marker Score: 429
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.03
    Marker Score: 283
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.02
    Marker Score: 606
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.01
    Marker Score: 534
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,042
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1
    Marker Score: 413
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15,512
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,472
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1,787
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,316
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.93
    Marker Score: 291
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.92
    Marker Score: 3,957
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.9
    Marker Score: 8,528
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 535
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.78
    Marker Score: 777
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.77
    Marker Score: 833
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.77
    Marker Score: 435
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.73
    Marker Score: 2,839
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 472
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.68
    Marker Score: 159
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.6
    Marker Score: 167
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 285
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.58
    Marker Score: 4,949
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 554
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.48
    Marker Score: 116
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.44
    Marker Score: 164
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 196
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.39
    Marker Score: 555
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.38
    Marker Score: 240
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.35
    Marker Score: 5,634
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.34
    Marker Score: 129
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 134
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.29
    Marker Score: 65
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.26
    Marker Score: 59
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.25
    Marker Score: 64
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.23
    Marker Score: 55
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.23
    Marker Score: 212
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.22
    Marker Score: 382
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.21
    Marker Score: 512
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 118
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.2
    Marker Score: 55
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.19
    Marker Score: 133
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.18
    Marker Score: 226
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.17
    Marker Score: 59
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.17
    Marker Score: 1,958
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.16
    Marker Score: 32
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.16
    Marker Score: 330
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 237
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.15
    Marker Score: 192
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.14
    Marker Score: 32
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.13
    Marker Score: 886
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 551

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: RAMP3 is a small protein with a single transmembrane domain, which allows it to interact with GPCRs and other proteins. 2. **Expression**: RAMP3 is highly expressed in endothelial cells, which suggests its importance in vascular biology. 3. **Function**: RAMP3 acts as a coreceptor, modifying the activity of GPCRs and modulating their signaling pathways. 4. **Signaling pathways**: RAMP3 is involved in various signaling pathways, including adenylate cyclase-activating GPCR signaling, adrenomedullin receptor signaling, and amyloid-β binding. 5. **Cellular localization**: RAMP3 is primarily found on the plasma membrane, where it interacts with GPCRs and other proteins. **Pathways and Functions** RAMP3's involvement in multiple signaling pathways makes it a critical regulator of cellular responses. Some of the key pathways and functions of RAMP3 include: 1. **Adenylate cyclase-activating GPCR signaling**: RAMP3 modulates the activity of GPCRs that activate adenylate cyclase, leading to increased cAMP levels and subsequent cellular responses. 2. **Adrenomedullin receptor signaling**: RAMP3 interacts with adrenomedullin receptors, modulating their signaling pathways and regulating vascular tone. 3. **Amyloid-β binding**: RAMP3 binds to amyloid-β, regulating its clearance and preventing its toxic effects on neurons. 4. **Calcium ion transport**: RAMP3 modulates calcium ion transport across cell membranes, regulating cellular responses to calcium signals. 5. **Gene expression**: RAMP3 regulates gene expression by modulating the activity of transcription factors and other regulatory proteins. **Clinical Significance** RAMP3's involvement in various signaling pathways makes it an important regulator of cellular responses. Dysregulation of RAMP3 has been implicated in several diseases, including: 1. **Cardiovascular disease**: RAMP3's role in regulating vascular tone and blood pressure makes it a potential target for therapies aimed at preventing cardiovascular disease. 2. **Neurodegenerative diseases**: RAMP3's involvement in amyloid-β binding and clearance makes it a potential target for therapies aimed at preventing or treating neurodegenerative diseases, such as Alzheimer's disease. 3. **Endothelial dysfunction**: RAMP3's role in regulating endothelial function makes it a potential target for therapies aimed at preventing or treating endothelial dysfunction, which is a hallmark of many cardiovascular diseases. In conclusion, RAMP3 is a critical gene involved in regulating various cellular processes, including signaling pathways and calcium-mediated signaling. Its dysregulation has been implicated in several diseases, making it a potential target for therapies aimed at preventing or treating these conditions. Further research is needed to fully understand the role of RAMP3 in human health and disease.

Genular Protein ID: 2167780151

Symbol: RAMP3_HUMAN

Name: Receptor activity-modifying protein 3

UniProtKB Accession Codes:

O60896 Q7Z2Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 5 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9620797

Title: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

PubMed ID: 9620797

DOI: 10.1038/30666

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23674134

Title: G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.

PubMed ID: 23674134

DOI: 10.1530/jme-13-0021

Sequence Information:

  • Length: 148
  • Mass: 16518
  • Checksum: EEEE312496EF513C
  • Sequence:
    • METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS 
EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEVLI 
PLIVIPVVLT VAMAGLVVWR SKRTDTLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.