ZMPSTE24 | ENSG00000084073 | NCBI 10269

Details for: ZMPSTE24

Gene ID: 10269

Symbol: ZMPSTE24

Ensembl ID: ENSG00000084073

Description: zinc metallopeptidase STE24

Associated with

Adult walking behavior
(GO:0007628)
Bone mineralization
(GO:0030282)
Caax-box protein processing
(GO:0071586)
Calcium ion import into sarcoplasmic reticulum
(GO:1990036)
Camkk-ampk signaling cascade
(GO:0061762)
Cardiac conduction
(GO:0061337)
Cardiac muscle cell development
(GO:0055013)
Cardiac ventricle development
(GO:0003231)
Cellular lipid metabolic process
(GO:0044255)
Cellular response to gamma radiation
(GO:0071480)
Determination of adult lifespan
(GO:0008340)
Dna repair
(GO:0006281)
Double-stranded dna binding
(GO:0003690)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum membrane
(GO:0005789)
Extracellular exosome
(GO:0070062)
Growth plate cartilage development
(GO:0003417)
Hair follicle development
(GO:0001942)
Heart morphogenesis
(GO:0003007)
Inflammatory cell apoptotic process
(GO:0006925)
Kidney morphogenesis
(GO:0060993)
Late endosome membrane
(GO:0031902)
Liver development
(GO:0001889)
Maintenance of rdna
(GO:0043007)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metalloexopeptidase activity
(GO:0008235)
Multicellular organism growth
(GO:0035264)
Negative regulation of mirna processing
(GO:1903799)
Neuromuscular process
(GO:0050905)
Nuclear envelope organization
(GO:0006998)
Nuclear inner membrane
(GO:0005637)
Positive regulation of gene expression via cpg island demethylation
(GO:0044029)
Prenylated protein catabolic process
(GO:0030327)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of autophagy
(GO:0010506)
Regulation of bone mineralization
(GO:0030500)
Regulation of cell shape
(GO:0008360)
Regulation of cellular senescence
(GO:2000772)
Regulation of defense response to virus
(GO:0050688)
Regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043516)
Regulation of dna methylation
(GO:0044030)
Regulation of fibroblast proliferation
(GO:0048145)
Regulation of glucose metabolic process
(GO:0010906)
Regulation of hormone metabolic process
(GO:0032350)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of mitotic cell cycle dna replication
(GO:1903463)
Regulation of multicellular organism growth
(GO:0040014)
Regulation of stress-activated protein kinase signaling cascade
(GO:0070302)
Regulation of termination of rna polymerase i transcription
(GO:2000730)
Regulation of tor signaling
(GO:0032006)
Regulation of ventricular cardiac muscle cell membrane repolarization
(GO:0060307)
Response to dna damage checkpoint signaling
(GO:0072423)
Thymus development
(GO:0048538)
Ventricular cardiac muscle tissue development
(GO:0003229)

Other Information

Proteins

CAAX prenyl protease 1 homolog

Genular Protein ID: 3372035895

Symbol: FACE1_HUMAN

Name: CAAX prenyl protease 1 homolog

UniProtKB Accession Codes:

O75844 B3KQI7 D3DPU7 Q8NDZ8 Q9UBQ2

Database IDs:

Citations:

PubMed ID: 10076063

Title: Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p.

PubMed ID: 10076063

DOI: 10.1016/s0304-4165(98)00170-6

PubMed ID: 9700155

Title: Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing.

PubMed ID: 9700155

DOI: 10.1083/jcb.142.3.635

PubMed ID: 10373325

Title: Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.

PubMed ID: 10373325

DOI: 10.1006/geno.1999.5834

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28246125

Title: ZMPSTE24 defends against influenza and other pathogenic viruses.

PubMed ID: 28246125

DOI: 10.1084/jem.20161270

PubMed ID: 28169297

Title: Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.

PubMed ID: 28169297

DOI: 10.1038/ncomms13876

PubMed ID: 33315887

Title: Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.

PubMed ID: 33315887

DOI: 10.1371/journal.pone.0239269

PubMed ID: 33293369

Title: Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.

PubMed ID: 33293369

DOI: 10.1074/jbc.ra120.015792

PubMed ID: 35283811

Title: Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity.

PubMed ID: 35283811

DOI: 10.3389/fmicb.2022.840885

PubMed ID: 23539603

Title: The structural basis of ZMPSTE24-dependent laminopathies.

PubMed ID: 23539603

DOI: 10.1126/science.1231513

PubMed ID: 12913070

Title: Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.

PubMed ID: 12913070

DOI: 10.1093/hmg/ddg213

PubMed ID: 15317753

Title: Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy.

PubMed ID: 15317753

DOI: 10.1093/hmg/ddh265

PubMed ID: 17152860

Title: Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency.

PubMed ID: 17152860

DOI: 10.2310/6650.2006.05068

PubMed ID: 18435794

Title: Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings.

PubMed ID: 18435794

DOI: 10.1111/j.1399-0004.2008.00992.x

PubMed ID: 20814950

Title: Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24.

PubMed ID: 20814950

DOI: 10.1002/ajmg.a.33664

Sequence Information:

Length: 475
Mass: 54813
Checksum: 6C49179DEB0C8F7F
Sequence:

MGMWASLDAL WEMPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTH VPPELGQIMD 
SETFEKSRLY QLDKSTFSFW SGLYSETEGT LILLFGGIPY LWRLSGRFCG YAGFGPEYEI 
TQSLVFLLLA TLFSALTGLP WSLYNTFVIE EKHGFNQQTL GFFMKDAIKK FVVTQCILLP 
VSSLLLYIIK IGGDYFFIYA WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKEEIEV 
MAKSIDFPLT KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVL NKDIQEDSGM 
EPRNEEEGNS EEIKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII ISQMNSFLCF 
FLFAVLIGRK ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN EVLSFCLTVL SRRFEFQADA 
FAKKLGKAKD LYSALIKLNK DNLGFPVSDW LFSMWHYSHP PLLERLQALK TMKQH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZMPSTE24

Associated with

Other Information

Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p. PubMed ID: 10076063

Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. PubMed ID: 9700155

Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. PubMed ID: 10373325

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

ZMPSTE24 defends against influenza and other pathogenic viruses. PubMed ID: 28246125

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction. PubMed ID: 28169297

Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24. PubMed ID: 33315887

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24. PubMed ID: 33293369

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity. PubMed ID: 35283811

The structural basis of ZMPSTE24-dependent laminopathies. PubMed ID: 23539603

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. PubMed ID: 12913070

Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. PubMed ID: 15317753

Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency. PubMed ID: 17152860

Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings. PubMed ID: 18435794

Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24. PubMed ID: 20814950