Details for: ZMPSTE24

Gene ID: 10269

Symbol: ZMPSTE24

Ensembl ID: ENSG00000084073

Description: zinc metallopeptidase STE24

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.82
    Marker Score: 3,015
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.59
    Marker Score: 4,008
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.58
    Marker Score: 842
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,573
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.46
    Marker Score: 3,202
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.4
    Marker Score: 1,282
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.23
    Marker Score: 3,012
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.14
    Marker Score: 9,944
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.14
    Marker Score: 1,516
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.14
    Marker Score: 9,812
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.13
    Marker Score: 3,024
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.12
    Marker Score: 2,555
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.12
    Marker Score: 28,578
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.1
    Marker Score: 577
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.02
    Marker Score: 3,523
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.01
    Marker Score: 586
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Marker Score: 3,933
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,678
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,902
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.99
    Marker Score: 1,396
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,385
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.97
    Marker Score: 1,840
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.97
    Marker Score: 9,980
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.96
    Marker Score: 3,919
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.95
    Marker Score: 1,465
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.94
    Marker Score: 981
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.94
    Marker Score: 351
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.93
    Marker Score: 8,028
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.92
    Marker Score: 3,987
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.92
    Marker Score: 5,617
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,198
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.91
    Marker Score: 453
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,693
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.9
    Marker Score: 911
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.88
    Marker Score: 416
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.88
    Marker Score: 586
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13,504
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.85
    Marker Score: 906
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.85
    Marker Score: 900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.85
    Marker Score: 241
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.85
    Marker Score: 341
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.84
    Marker Score: 351
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.84
    Marker Score: 196
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.83
    Marker Score: 390
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.83
    Marker Score: 554
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.83
    Marker Score: 1,222
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.83
    Marker Score: 408
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 50,759
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.82
    Marker Score: 287
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.82
    Marker Score: 1,862
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.82
    Marker Score: 14,500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.81
    Marker Score: 235
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.81
    Marker Score: 7,714
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.81
    Marker Score: 3,887
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.81
    Marker Score: 2,872
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.81
    Marker Score: 552
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.79
    Marker Score: 2,482
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.79
    Marker Score: 27,278
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.77
    Marker Score: 191
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.77
    Marker Score: 488
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.77
    Marker Score: 521
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.77
    Marker Score: 523
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.76
    Marker Score: 1,228
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.76
    Marker Score: 1,426
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.76
    Marker Score: 817
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.75
    Marker Score: 973
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.75
    Marker Score: 237
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.75
    Marker Score: 4,761
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.74
    Marker Score: 1,021
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.74
    Marker Score: 8,327
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.74
    Marker Score: 778
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.74
    Marker Score: 1,473
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.74
    Marker Score: 1,172
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.73
    Marker Score: 187
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.73
    Marker Score: 1,744
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.73
    Marker Score: 1,918
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 787
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.73
    Marker Score: 1,517
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.72
    Marker Score: 449
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.72
    Marker Score: 840
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.72
    Marker Score: 268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.72
    Marker Score: 4,572
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,992
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.71
    Marker Score: 437
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.71
    Marker Score: 8,275
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7
    Marker Score: 628
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.7
    Marker Score: 510
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.69
    Marker Score: 4,519
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.69
    Marker Score: 732
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.69
    Marker Score: 1,783
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.68
    Marker Score: 610

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **CAAX prenyl protease activity**: ZMPSTE24 is a metallopeptidase that specifically cleaves CAAX prenyl motifs, which are essential for the localization and function of various proteins. 2. **Widespread tissue expression**: ZMPSTE24 is expressed in multiple tissues, including the kidney, heart, brain, and epithelial cells, suggesting its importance in various cellular processes. 3. **Multiple cellular functions**: ZMPSTE24 is involved in processes such as bone mineralization, cell development, and response to DNA damage, highlighting its multifaceted role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Bone mineralization**: ZMPSTE24 is involved in regulating bone mineralization by processing CAAX prenyl motifs in osteoblasts and osteoclasts. 2. **Cell development**: ZMPSTE24 plays a crucial role in the development of various cell types, including cardiac muscle cells, kidney collecting duct cells, and epithelial cells. 3. **Response to DNA damage**: ZMPSTE24 is involved in the response to DNA damage by regulating the processing of CAAX prenyl motifs in proteins involved in DNA repair. 4. **Signal transduction**: ZMPSTE24 is involved in signal transduction pathways, including the Camkk-ampk signaling cascade, which regulates cellular metabolism and stress response. 5. **Autophagy regulation**: ZMPSTE24 is involved in regulating autophagy by processing CAAX prenyl motifs in proteins involved in autophagy. **Clinical Significance:** Dysregulation of ZMPSTE24 has been implicated in various diseases, including: 1. **Atherosclerosis**: ZMPSTE24 deficiency has been linked to atherosclerosis, a condition characterized by the buildup of fatty deposits in arteries. 2. **Bone disorders**: ZMPSTE24 deficiency has been associated with osteoporosis, a condition characterized by brittle bones and increased risk of fractures. 3. **Neurological disorders**: ZMPSTE24 deficiency has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ZMPSTE24 is a multifunctional enzyme that plays a crucial role in various cellular processes, including bone mineralization, cell development, and response to DNA damage. Further research is needed to fully understand the mechanisms of ZMPSTE24 and its role in human disease.

Genular Protein ID: 3372035895

Symbol: FACE1_HUMAN

Name: CAAX prenyl protease 1 homolog

UniProtKB Accession Codes:

O75844 B3KQI7 D3DPU7 Q8NDZ8 Q9UBQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 57 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10076063

Title: Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p.

PubMed ID: 10076063

DOI: 10.1016/s0304-4165(98)00170-6

PubMed ID: 9700155

Title: Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing.

PubMed ID: 9700155

DOI: 10.1083/jcb.142.3.635

PubMed ID: 10373325

Title: Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.

PubMed ID: 10373325

DOI: 10.1006/geno.1999.5834

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28246125

Title: ZMPSTE24 defends against influenza and other pathogenic viruses.

PubMed ID: 28246125

DOI: 10.1084/jem.20161270

PubMed ID: 28169297

Title: Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.

PubMed ID: 28169297

DOI: 10.1038/ncomms13876

PubMed ID: 33315887

Title: Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.

PubMed ID: 33315887

DOI: 10.1371/journal.pone.0239269

PubMed ID: 33293369

Title: Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.

PubMed ID: 33293369

DOI: 10.1074/jbc.ra120.015792

PubMed ID: 35283811

Title: Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity.

PubMed ID: 35283811

DOI: 10.3389/fmicb.2022.840885

PubMed ID: 23539603

Title: The structural basis of ZMPSTE24-dependent laminopathies.

PubMed ID: 23539603

DOI: 10.1126/science.1231513

PubMed ID: 12913070

Title: Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.

PubMed ID: 12913070

DOI: 10.1093/hmg/ddg213

PubMed ID: 15317753

Title: Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy.

PubMed ID: 15317753

DOI: 10.1093/hmg/ddh265

PubMed ID: 17152860

Title: Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency.

PubMed ID: 17152860

DOI: 10.2310/6650.2006.05068

PubMed ID: 18435794

Title: Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings.

PubMed ID: 18435794

DOI: 10.1111/j.1399-0004.2008.00992.x

PubMed ID: 20814950

Title: Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24.

PubMed ID: 20814950

DOI: 10.1002/ajmg.a.33664

Sequence Information:

  • Length: 475
  • Mass: 54813
  • Checksum: 6C49179DEB0C8F7F
  • Sequence:
    • MGMWASLDAL WEMPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTH VPPELGQIMD 
SETFEKSRLY QLDKSTFSFW SGLYSETEGT LILLFGGIPY LWRLSGRFCG YAGFGPEYEI 
TQSLVFLLLA TLFSALTGLP WSLYNTFVIE EKHGFNQQTL GFFMKDAIKK FVVTQCILLP 
VSSLLLYIIK IGGDYFFIYA WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKEEIEV 
MAKSIDFPLT KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVL NKDIQEDSGM 
EPRNEEEGNS EEIKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII ISQMNSFLCF 
FLFAVLIGRK ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN EVLSFCLTVL SRRFEFQADA 
FAKKLGKAKD LYSALIKLNK DNLGFPVSDW LFSMWHYSHP PLLERLQALK TMKQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.