CDKN1B | ENSG00000111276 | NCBI 1027

Details for: CDKN1B

Gene ID: 1027

Symbol: CDKN1B

Ensembl ID: ENSG00000111276

Description: cyclin dependent kinase inhibitor 1B

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
G1 phase
(R-HSA-69236)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate cit
(R-HSA-5625900)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ptk6
(R-HSA-8848021)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Autophagic cell death
(GO:0048102)
Cyclin-dependent protein kinase activating kinase regulator activity
(GO:0019914)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin binding
(GO:0030332)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
G1/s transition of mitotic cell cycle
(GO:0000082)
Heart development
(GO:0007507)
Hsp70 protein binding
(GO:0030544)
Molecular adaptor activity
(GO:0060090)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of kinase activity
(GO:0033673)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of phosphorylation
(GO:0042326)
Notch signaling pathway
(GO:0007219)
Placenta development
(GO:0001890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of microtubule polymerization
(GO:0031116)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein phosphorylation
(GO:0001934)
Potassium ion transport
(GO:0006813)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein phosphatase binding
(GO:0019903)
Regulation of cell migration
(GO:0030334)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of exit from mitosis
(GO:0007096)
Response to amino acid
(GO:0043200)
Response to cadmium ion
(GO:0046686)
Response to estradiol
(GO:0032355)
Response to glucose
(GO:0009749)
Response to peptide hormone
(GO:0043434)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of sound
(GO:0007605)
Ubiquitin ligase activator activity
(GO:1990757)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Cyclin-dependent kinase inhibitor 1B

Genular Protein ID: 2683352658

Symbol: CDN1B_HUMAN

Name: Cyclin-dependent kinase inhibitor 1B

UniProtKB Accession Codes:

P46527 Q16307 Q5U0H2 Q9BUS6

Database IDs:

Citations:

PubMed ID: 8033212

Title: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

PubMed ID: 8033212

DOI: 10.1016/0092-8674(94)90572-x

PubMed ID: 7882309

Title: Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

PubMed ID: 7882309

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10323868

Title: Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

PubMed ID: 10323868

DOI: 10.1101/gad.13.9.1181

PubMed ID: 10831586

Title: Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.

PubMed ID: 10831586

DOI: 10.1074/jbc.m001144200

PubMed ID: 12093740

Title: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

PubMed ID: 12093740

DOI: 10.1093/emboj/cdf343

PubMed ID: 12042314

Title: Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 12042314

DOI: 10.1074/jbc.m203668200

PubMed ID: 12244303

Title: Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.

PubMed ID: 12244303

DOI: 10.1038/nm762

PubMed ID: 12244301

Title: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.

PubMed ID: 12244301

DOI: 10.1038/nm759

PubMed ID: 14504289

Title: Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 14504289

DOI: 10.1074/jbc.m306614200

PubMed ID: 12972555

Title: Spy1 interacts with p27Kip1 to allow G1/S progression.

PubMed ID: 12972555

DOI: 10.1091/mbc.e02-12-0820

PubMed ID: 15509543

Title: Calcineurin A-alpha but not A-beta is required for normal kidney development and function.

PubMed ID: 15509543

DOI: 10.1016/s0002-9440(10)63430-x

PubMed ID: 15280662

Title: Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.

PubMed ID: 15280662

PubMed ID: 16007079

Title: Cdc2-cyclin E complexes regulate the G1/S phase transition.

PubMed ID: 16007079

DOI: 10.1038/ncb1284

PubMed ID: 16195327

Title: Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

PubMed ID: 16195327

DOI: 10.1182/blood-2005-05-1771

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 16880511

Title: Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.

PubMed ID: 16880511

DOI: 10.1128/mcb.01630-05

PubMed ID: 17030811

Title: Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans.

PubMed ID: 17030811

DOI: 10.1073/pnas.0603877103

PubMed ID: 17254967

Title: p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.

PubMed ID: 17254967

DOI: 10.1016/j.cell.2006.11.049

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18593906

Title: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.

PubMed ID: 18593906

DOI: 10.1158/0008-5472.can-08-0634

PubMed ID: 19075005

Title: p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

PubMed ID: 19075005

DOI: 10.1128/mcb.00898-08

PubMed ID: 22586611

Title: PPM1H is a p27 phosphatase implicated in trastuzumab resistance.

PubMed ID: 22586611

DOI: 10.1158/2159-8290.cd-11-0062

PubMed ID: 21423214

Title: Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.

PubMed ID: 21423214

DOI: 10.1038/onc.2011.68

PubMed ID: 23707388

Title: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.

PubMed ID: 23707388

DOI: 10.1016/j.cellsig.2013.05.012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478441

Title: Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.

PubMed ID: 23478441

DOI: 10.1016/j.molcel.2013.02.004

PubMed ID: 26775844

Title: Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination.

PubMed ID: 26775844

DOI: 10.1016/j.bbrc.2016.01.072

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 16209941

Title: Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.

PubMed ID: 16209941

DOI: 10.1016/j.molcel.2005.09.003

PubMed ID: 17254966

Title: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

PubMed ID: 17254966

DOI: 10.1016/j.cell.2006.11.047

PubMed ID: 28666995

Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.

PubMed ID: 28666995

DOI: 10.15252/embj.201796905

PubMed ID: 20824794

Title: A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.

PubMed ID: 20824794

DOI: 10.1002/humu.21354

Sequence Information:

Length: 198
Mass: 22073
Checksum: 1118D58901CDF3FC
Sequence:

MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW 
NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG 
APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN 
AGSVEQTPKK PGLRRRQT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN1B

Associated with

Other Information

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. PubMed ID: 8033212

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. PubMed ID: 7882309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. PubMed ID: 10323868

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. PubMed ID: 10831586

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. PubMed ID: 12093740

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. PubMed ID: 12042314

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. PubMed ID: 12244303

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. PubMed ID: 12244301

Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. PubMed ID: 14504289

Spy1 interacts with p27Kip1 to allow G1/S progression. PubMed ID: 12972555

Calcineurin A-alpha but not A-beta is required for normal kidney development and function. PubMed ID: 15509543

Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer. PubMed ID: 15280662

Cdc2-cyclin E complexes regulate the G1/S phase transition. PubMed ID: 16007079

Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. PubMed ID: 16195327

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. PubMed ID: 16782892

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. PubMed ID: 16880511

Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans. PubMed ID: 17030811

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. PubMed ID: 17254967

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. PubMed ID: 18593906

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. PubMed ID: 19075005

PPM1H is a p27 phosphatase implicated in trastuzumab resistance. PubMed ID: 22586611

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. PubMed ID: 21423214

Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. PubMed ID: 23707388

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. PubMed ID: 23478441

Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination. PubMed ID: 26775844

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. PubMed ID: 8684460

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. PubMed ID: 16209941

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. PubMed ID: 17254966

Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. PubMed ID: 28666995

A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization. PubMed ID: 20824794