CDKN1B | ENSG00000111276 | NCBI 1027

Details for: CDKN1B

Gene ID: 1027

Symbol: CDKN1B

Ensembl ID: ENSG00000111276

Description: cyclin dependent kinase inhibitor 1B

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
G1 phase
(R-HSA-69236)
G1/s dna damage checkpoints
(R-HSA-69615)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
P53-dependent g1 dna damage response
(R-HSA-69563)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate cit
(R-HSA-5625900)
Rna polymerase ii transcription
(R-HSA-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ptk6
(R-HSA-8848021)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-HSA-6804116)
Transcriptional regulation by tp53
(R-HSA-3700989)
Autophagic cell death
(GO:0048102)
Cyclin-dependent protein kinase activating kinase regulator activity
(GO:0019914)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin binding
(GO:0030332)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
G1/s transition of mitotic cell cycle
(GO:0000082)
Heart development
(GO:0007507)
Hsp70 protein binding
(GO:0030544)
Inner ear development
(GO:0048839)
Molecular adaptor activity
(GO:0060090)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of kinase activity
(GO:0033673)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of phosphorylation
(GO:0042326)
Notch signaling pathway
(GO:0007219)
Nuclear export
(GO:0051168)
Placenta development
(GO:0001890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of microtubule polymerization
(GO:0031116)
Positive regulation of protein catabolic process
(GO:0045732)
Potassium ion transport
(GO:0006813)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase inhibitor activity
(GO:0004860)
Protein phosphatase binding
(GO:0019903)
Regulation of cell migration
(GO:0030334)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of exit from mitosis
(GO:0007096)
Response to amino acid
(GO:0043200)
Response to cadmium ion
(GO:0046686)
Response to estradiol
(GO:0032355)
Response to glucose
(GO:0009749)
Response to peptide hormone
(GO:0043434)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of sound
(GO:0007605)
Ubiquitin ligase activator activity
(GO:1990757)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 238.6766
Cell Significance Index: -37.1300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 153.5621
Cell Significance Index: -38.9500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 101.5420
Cell Significance Index: -41.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 91.3957
Cell Significance Index: -43.1500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 82.7201
Cell Significance Index: -42.5500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 64.4241
Cell Significance Index: -43.2300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.2072
Cell Significance Index: -39.7100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.4856
Cell Significance Index: -38.8100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.6233
Cell Significance Index: -41.9200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.1850
Cell Significance Index: -25.1400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.0489
Cell Significance Index: -11.0500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.8072
Cell Significance Index: 194.1400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.5675
Cell Significance Index: 101.1300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5217
Cell Significance Index: 165.5200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.5054
Cell Significance Index: 90.3800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.0944
Cell Significance Index: 57.4600
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.6113
Cell Significance Index: 8.5800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5312
Cell Significance Index: 37.5700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5160
Cell Significance Index: 228.1300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5084
Cell Significance Index: 69.8200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4625
Cell Significance Index: 88.0300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4213
Cell Significance Index: 54.0100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3510
Cell Significance Index: 43.1600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3288
Cell Significance Index: 8.2200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3071
Cell Significance Index: 167.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2766
Cell Significance Index: 13.0000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2650
Cell Significance Index: 47.7700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2429
Cell Significance Index: 15.3100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2364
Cell Significance Index: 23.3900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2348
Cell Significance Index: 84.2100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2315
Cell Significance Index: 46.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2122
Cell Significance Index: 9.6200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2114
Cell Significance Index: 41.9500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1819
Cell Significance Index: 3.9400
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.1649
Cell Significance Index: 1.0200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1320
Cell Significance Index: 21.4700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1059
Cell Significance Index: 12.4900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0687
Cell Significance Index: 4.2200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0189
Cell Significance Index: 3.2300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0071
Cell Significance Index: 4.8900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0025
Cell Significance Index: 4.7300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0015
Cell Significance Index: -0.0400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0060
Cell Significance Index: -0.2800
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0104
Cell Significance Index: -0.0800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0116
Cell Significance Index: -7.2500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0126
Cell Significance Index: -19.3900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0148
Cell Significance Index: -10.9800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0160
Cell Significance Index: -21.7600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0205
Cell Significance Index: -37.8000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0299
Cell Significance Index: -22.6500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0311
Cell Significance Index: -22.8300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0453
Cell Significance Index: -4.6300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0474
Cell Significance Index: -30.1100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0495
Cell Significance Index: -27.9000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0603
Cell Significance Index: -1.5900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0619
Cell Significance Index: -28.0800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0730
Cell Significance Index: -5.4400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0866
Cell Significance Index: -1.4500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0944
Cell Significance Index: -19.8800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1113
Cell Significance Index: -2.9800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1150
Cell Significance Index: -33.1000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1386
Cell Significance Index: -17.9100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2025
Cell Significance Index: -29.4400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2048
Cell Significance Index: -23.4600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2072
Cell Significance Index: -7.2800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2170
Cell Significance Index: -25.2900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2322
Cell Significance Index: -4.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2491
Cell Significance Index: -13.9800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2541
Cell Significance Index: -29.0100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2541
Cell Significance Index: -7.1000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2655
Cell Significance Index: -7.1200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3017
Cell Significance Index: -8.8600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3155
Cell Significance Index: -16.3900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3335
Cell Significance Index: -11.5900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3534
Cell Significance Index: -9.6200
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.3820
Cell Significance Index: -3.8300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3868
Cell Significance Index: -40.2800
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.3972
Cell Significance Index: -4.2200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4382
Cell Significance Index: -33.6300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4481
Cell Significance Index: -35.4900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4977
Cell Significance Index: -15.9400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4986
Cell Significance Index: -8.5500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5330
Cell Significance Index: -35.8400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5343
Cell Significance Index: -15.3200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5487
Cell Significance Index: -11.6900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5870
Cell Significance Index: -35.9900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5958
Cell Significance Index: -3.6000
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6183
Cell Significance Index: -7.3700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6440
Cell Significance Index: -13.7700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.6567
Cell Significance Index: -7.4600
Cell Name: peg cell (CL4033014)
Fold Change: -0.6715
Cell Significance Index: -15.5200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.7062
Cell Significance Index: -13.0500
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.7303
Cell Significance Index: -12.5900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.7405
Cell Significance Index: -6.2200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.7432
Cell Significance Index: -6.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7676
Cell Significance Index: -22.1200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7735
Cell Significance Index: -18.5500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8419
Cell Significance Index: -21.6400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8599
Cell Significance Index: -38.0400
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.9039
Cell Significance Index: -6.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CDKN1B is a small, non-coding RNA molecule that is highly conserved across species. It is synthesized as a precursor molecule, which is then processed into a mature RNA molecule. CDKN1B is expressed in a variety of cell types, including immune cells, fibroblasts, and germ cells. It is also known to be regulated by various signaling pathways, including the PI3K/Akt pathway and the p53 pathway. CDKN1B has been implicated in several diseases, including cancer, where its expression is often downregulated. **Pathways and Functions** CDKN1B plays a critical role in regulating the cell cycle, particularly at the G1/S transition. It inhibits the activity of CDK4/6, which are essential for the phosphorylation and activation of the Rb protein. This mechanism prevents the transition from the G1 phase to the S phase of the cell cycle, thereby inhibiting cell proliferation. CDKN1B also interacts with other proteins, including p21 and p27, to regulate the cell cycle. Additionally, CDKN1B has been implicated in various signaling pathways, including the PI3K/Akt pathway and the p53 pathway, where it regulates the activity of key enzymes, such as Akt and p53. **Clinical Significance** CDKN1B has been implicated in several diseases, including cancer. Its expression is often downregulated in cancer cells, leading to uncontrolled cell proliferation. CDKN1B has been proposed as a potential biomarker for cancer diagnosis and prognosis. Additionally, CDKN1B has been shown to have therapeutic potential in cancer treatment. Inhibitors of CDKN1B, such as the CDK4/6 inhibitors, have been developed to target the CDKN1B pathway and prevent cancer cell proliferation. In conclusion, CDKN1B is a critical regulator of the cell cycle, particularly at the G1/S transition. Its expression is highly conserved across species and is regulated by various signaling pathways. CDKN1B has been implicated in several diseases, including cancer, where its expression is often downregulated. Its therapeutic potential has been proposed, and inhibitors of CDKN1B are being developed to target the CDKN1B pathway and prevent cancer cell proliferation. **Implications for Immunology** CDKN1B has been shown to play a critical role in regulating the immune response. It has been implicated in the development and function of immune cells, including T cells and B cells. CDKN1B has been shown to regulate the activity of key enzymes, such as Akt and p53, which are essential for the regulation of immune cell function. Additionally, CDKN1B has been implicated in the regulation of the senescence-associated secretory phenotype (SASP), which is a key mechanism of immune suppression in cancer. Understanding the role of CDKN1B in the immune response has important implications for the development of immunotherapies for cancer. **Implications for Cancer Therapy** CDKN1B has been shown to play a critical role in regulating cancer cell proliferation. Its expression is often downregulated in cancer cells, leading to uncontrolled cell proliferation. CDKN1B has been proposed as a potential biomarker for cancer diagnosis and prognosis. Additionally, CDKN1B has been shown to have therapeutic potential in cancer treatment. Inhibitors of CDKN1B, such as the CDK4/6 inhibitors, have been developed to target the CDKN1B pathway and prevent cancer cell proliferation. Understanding the role of CDKN1B in cancer has important implications for the development of novel cancer therapies. In conclusion, CDKN1B is a critical regulator of the cell cycle, particularly at the G1/S transition. Its expression is highly conserved across species and is regulated by various signaling pathways. CDKN1B has been implicated in several diseases, including cancer, where its expression is often downregulated. Its therapeutic potential has been proposed, and inhibitors of CDKN1B are being developed to target the CDKN1B pathway and prevent cancer cell proliferation. Understanding the role of CDKN1B in the immune response and cancer has important implications for the development of novel therapies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclin-dependent kinase inhibitor 1B

Genular Protein ID: 2683352658

Symbol: CDN1B_HUMAN

Name: Cyclin-dependent kinase inhibitor 1B

UniProtKB Accession Codes:

P46527 Q16307 Q5U0H2 Q9BUS6

Database IDs:

Citations:

PubMed ID: 8033212

Title: Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

PubMed ID: 8033212

DOI: 10.1016/0092-8674(94)90572-x

PubMed ID: 7882309

Title: Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

PubMed ID: 7882309

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10323868

Title: Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

PubMed ID: 10323868

DOI: 10.1101/gad.13.9.1181

PubMed ID: 10831586

Title: Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.

PubMed ID: 10831586

DOI: 10.1074/jbc.m001144200

PubMed ID: 12093740

Title: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

PubMed ID: 12093740

DOI: 10.1093/emboj/cdf343

PubMed ID: 12042314

Title: Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 12042314

DOI: 10.1074/jbc.m203668200

PubMed ID: 12244303

Title: Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.

PubMed ID: 12244303

DOI: 10.1038/nm762

PubMed ID: 12244301

Title: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.

PubMed ID: 12244301

DOI: 10.1038/nm759

PubMed ID: 14504289

Title: Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 14504289

DOI: 10.1074/jbc.m306614200

PubMed ID: 12972555

Title: Spy1 interacts with p27Kip1 to allow G1/S progression.

PubMed ID: 12972555

DOI: 10.1091/mbc.e02-12-0820

PubMed ID: 15509543

Title: Calcineurin A-alpha but not A-beta is required for normal kidney development and function.

PubMed ID: 15509543

DOI: 10.1016/s0002-9440(10)63430-x

PubMed ID: 15280662

Title: Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.

PubMed ID: 15280662

PubMed ID: 16007079

Title: Cdc2-cyclin E complexes regulate the G1/S phase transition.

PubMed ID: 16007079

DOI: 10.1038/ncb1284

PubMed ID: 16195327

Title: Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

PubMed ID: 16195327

DOI: 10.1182/blood-2005-05-1771

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 16880511

Title: Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.

PubMed ID: 16880511

DOI: 10.1128/mcb.01630-05

PubMed ID: 17030811

Title: Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans.

PubMed ID: 17030811

DOI: 10.1073/pnas.0603877103

PubMed ID: 17254967

Title: p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.

PubMed ID: 17254967

DOI: 10.1016/j.cell.2006.11.049

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18593906

Title: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.

PubMed ID: 18593906

DOI: 10.1158/0008-5472.can-08-0634

PubMed ID: 19075005

Title: p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

PubMed ID: 19075005

DOI: 10.1128/mcb.00898-08

PubMed ID: 22586611

Title: PPM1H is a p27 phosphatase implicated in trastuzumab resistance.

PubMed ID: 22586611

DOI: 10.1158/2159-8290.cd-11-0062

PubMed ID: 21423214

Title: Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.

PubMed ID: 21423214

DOI: 10.1038/onc.2011.68

PubMed ID: 23707388

Title: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.

PubMed ID: 23707388

DOI: 10.1016/j.cellsig.2013.05.012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478441

Title: Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.

PubMed ID: 23478441

DOI: 10.1016/j.molcel.2013.02.004

PubMed ID: 26775844

Title: Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination.

PubMed ID: 26775844

DOI: 10.1016/j.bbrc.2016.01.072

PubMed ID: 8684460

Title: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

PubMed ID: 8684460

DOI: 10.1038/382325a0

PubMed ID: 16209941

Title: Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.

PubMed ID: 16209941

DOI: 10.1016/j.molcel.2005.09.003

PubMed ID: 17254966

Title: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.

PubMed ID: 17254966

DOI: 10.1016/j.cell.2006.11.047

PubMed ID: 28666995

Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.

PubMed ID: 28666995

DOI: 10.15252/embj.201796905

PubMed ID: 20824794

Title: A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.

PubMed ID: 20824794

DOI: 10.1002/humu.21354

Sequence Information:

Length: 198
Mass: 22073
Checksum: 1118D58901CDF3FC
Sequence:

MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW 
NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG 
APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN 
AGSVEQTPKK PGLRRRQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN1B

Associated with

Cells (max top 100)

Other Information

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. PubMed ID: 8033212

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. PubMed ID: 7882309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. PubMed ID: 10323868

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. PubMed ID: 10831586

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. PubMed ID: 12093740

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. PubMed ID: 12042314

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. PubMed ID: 12244303

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. PubMed ID: 12244301

Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. PubMed ID: 14504289

Spy1 interacts with p27Kip1 to allow G1/S progression. PubMed ID: 12972555

Calcineurin A-alpha but not A-beta is required for normal kidney development and function. PubMed ID: 15509543

Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer. PubMed ID: 15280662

Cdc2-cyclin E complexes regulate the G1/S phase transition. PubMed ID: 16007079

Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. PubMed ID: 16195327

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'. PubMed ID: 16782892

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. PubMed ID: 16880511

Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans. PubMed ID: 17030811

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. PubMed ID: 17254967

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. PubMed ID: 18593906

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. PubMed ID: 19075005

PPM1H is a p27 phosphatase implicated in trastuzumab resistance. PubMed ID: 22586611

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. PubMed ID: 21423214

Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. PubMed ID: 23707388

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. PubMed ID: 23478441

Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination. PubMed ID: 26775844

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. PubMed ID: 8684460

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. PubMed ID: 16209941

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. PubMed ID: 17254966

Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. PubMed ID: 28666995

A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization. PubMed ID: 20824794