Details for: STUB1
Associated with
Other Information
Genular Protein ID: 3058385782
Symbol: CHIP_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9610721
Title: Characterization of human colon cancer antigens recognized by autologous antibodies.
PubMed ID: 9610721
DOI: 10.1002/(sici)1097-0215(19980529)76:5<652::aid-ijc7>3.0.co;2-p
PubMed ID: 10330192
Title: Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.
PubMed ID: 10330192
PubMed ID: 12200376
Title: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.
PubMed ID: 12200376
PubMed ID: 11157797
Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
PubMed ID: 11157797
DOI: 10.1093/hmg/10.4.339
PubMed ID: 15498874
Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.
PubMed ID: 15498874
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11435423
Title: U box proteins as a new family of ubiquitin-protein ligases.
PubMed ID: 11435423
PubMed ID: 11557750
Title: CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.
PubMed ID: 11557750
PubMed ID: 11146632
Title: The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins.
PubMed ID: 11146632
DOI: 10.1038/35050618
PubMed ID: 15466472
Title: Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
PubMed ID: 15466472
PubMed ID: 15215316
Title: The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.
PubMed ID: 15215316
PubMed ID: 16169850
Title: Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
PubMed ID: 16169850
PubMed ID: 16307917
Title: Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
PubMed ID: 16307917
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17369820
Title: The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.
PubMed ID: 17369820
DOI: 10.1038/ncb1554
PubMed ID: 18042044
Title: Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.
PubMed ID: 18042044
DOI: 10.1042/bj20071338
PubMed ID: 18094050
Title: MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination.
PubMed ID: 18094050
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19103148
Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.
PubMed ID: 19103148
PubMed ID: 19713937
Title: Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
PubMed ID: 19713937
PubMed ID: 19423554
Title: Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.
PubMed ID: 19423554
DOI: 10.1093/hmg/ddp215
PubMed ID: 19567782
Title: Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.
PubMed ID: 19567782
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22366786
Title: Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
PubMed ID: 22366786
DOI: 10.1038/ng.1103
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23560854
Title: Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini.
PubMed ID: 23560854
DOI: 10.1042/bj20130244
PubMed ID: 23973223
Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.
PubMed ID: 23973223
PubMed ID: 23990462
Title: Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.
PubMed ID: 23990462
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24043303
Title: The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
PubMed ID: 24043303
DOI: 10.1128/mcb.00480-13
PubMed ID: 24613385
Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.
PubMed ID: 24613385
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27353360
Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
PubMed ID: 27353360
DOI: 10.1038/ncomms12037
PubMed ID: 27708256
Title: ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
PubMed ID: 27708256
DOI: 10.1038/ncomms12882
PubMed ID: 28813410
Title: Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
PubMed ID: 28813410
DOI: 10.1038/nature23669
PubMed ID: 29883609
Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.
PubMed ID: 29883609
PubMed ID: 30381368
Title: Heterozygous STUB1 mutation causes familial ataxia with cognitive affective syndrome (SCA48).
PubMed ID: 30381368
PubMed ID: 33376131
Title: The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.
PubMed ID: 33376131
PubMed ID: 24312598
Title: Identification of CHIP as a novel causative gene for autosomal recessive cerebellar ataxia.
PubMed ID: 24312598
PubMed ID: 24113144
Title: Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP.
PubMed ID: 24113144
DOI: 10.1093/hmg/ddt497
PubMed ID: 24742043
Title: Phenotype and frequency of STUB1 mutations: next-generation screenings in Caucasian ataxia and spastic paraplegia cohorts.
PubMed ID: 24742043
PubMed ID: 24719489
Title: Autosomal recessive cerebellar ataxia of adult onset due to STUB1 mutations.
PubMed ID: 24719489
PubMed ID: 25258038
Title: STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity.
PubMed ID: 25258038
PubMed ID: 33798445
Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.
PubMed ID: 33798445
Sequence Information:
- Length: 303
- Mass: 34856
- Checksum: 7E7D6568B17070BF
- Sequence:
MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.