Details for: SIGMAR1

Gene ID: 10280

Symbol: SIGMAR1

Ensembl ID: ENSG00000147955

Description: sigma non-opioid intracellular receptor 1

Associated with

Other Information

Genular Protein ID: 1518399889

Symbol: SGMR1_HUMAN

Name: Sigma non-opioid intracellular receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8954936

Title: Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).

PubMed ID: 8954936

DOI: 10.1006/bbrc.1996.1842

PubMed ID: 9341151

Title: Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase.

PubMed ID: 9341151

DOI: 10.1074/jbc.272.43.27107

PubMed ID: 9453537

Title: Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene.

PubMed ID: 9453537

DOI: 10.1046/j.1471-4159.1998.70020443.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10406945

Title: Colocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope level.

PubMed ID: 10406945

DOI: 10.1046/j.1432-1327.1999.00500.x

PubMed ID: 10087012

Title: Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line.

PubMed ID: 10087012

PubMed ID: 11476895

Title: Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor.

PubMed ID: 11476895

DOI: 10.1016/s0167-4889(01)00117-3

PubMed ID: 11687279

Title: Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina.

PubMed ID: 11687279

DOI: 10.1016/s0169-328x(01)00249-2

PubMed ID: 16472803

Title: Silencing of sigma-1 receptor induces cell death in human lens cells.

PubMed ID: 16472803

DOI: 10.1016/j.yexcr.2006.01.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25647032

Title: Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor.

PubMed ID: 25647032

DOI: 10.1016/j.febslet.2015.01.033

PubMed ID: 27042935

Title: Crystal structure of the human sigma1 receptor.

PubMed ID: 27042935

DOI: 10.1038/nature17391

PubMed ID: 15298647

Title: Lack of association between sigma receptor gene variants and schizophrenia.

PubMed ID: 15298647

DOI: 10.1111/j.1440-1819.2004.01268.x

PubMed ID: 21842496

Title: A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.

PubMed ID: 21842496

DOI: 10.1002/ana.22534

PubMed ID: 22292588

Title: S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.

PubMed ID: 22292588

DOI: 10.1517/17425255.2012.658367

PubMed ID: 23314020

Title: Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis.

PubMed ID: 23314020

DOI: 10.1093/hmg/ddt008

PubMed ID: 26078401

Title: A SIGMAR1 splice-site mutation causes distal hereditary motor neuropathy.

PubMed ID: 26078401

DOI: 10.1212/wnl.0000000000001680

PubMed ID: 27629094

Title: SIGMAR1 mutation associated with autosomal recessive Silver-like syndrome.

PubMed ID: 27629094

DOI: 10.1212/wnl.0000000000003212

Sequence Information:

  • Length: 223
  • Mass: 25128
  • Checksum: 0C498636BEB1C443
  • Sequence:
  • MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 
    LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGRY 
    WAEISDTIIS GTFHQWREGT TKSEVFYPGE TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS 
    TLAFALADTV FSTQDFLTLF YTLRSYARGL RLELTTYLFG QDP

Genular Protein ID: 3550552395

Symbol: A2A3U5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 192
  • Mass: 21483
  • Checksum: 9E0C6A120A89126F
  • Sequence:
  • MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 
    LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGET 
    VVHGPGEATA VEWGPNTWMV EYGRGVIPST LAFALADTVF STQDFLTLFY TLRSYARGLR 
    LELTTYLFGQ DP

Genular Protein ID: 1968002082

Symbol: A0A7P0Z4C2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 159
  • Mass: 17503
  • Checksum: F132C35E3F9B03D4
  • Sequence:
  • MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 
    LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSVSC 
    AIVTQGATGL RSRIPSSLAP STSGERAPPK VRSSTQGRR

Genular Protein ID: 1629791372

Symbol: B4DR71_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 155
  • Mass: 17497
  • Checksum: 42829829275B76EF
  • Sequence:
  • MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 
    LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEYVLLFGTA LGSRGHSGRY 
    WAEISDTIIS GTFHQWREGT TKSEVFYPGP LTSQA

Genular Protein ID: 3120158282

Symbol: A0A7P0T9D5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 110
  • Mass: 12468
  • Checksum: 0DBDD2BB7780867F
  • Sequence:
  • MQWAVGRRWA WAALLLAVAA VLTQVVWLWL GTQSFVFQRE EIAQLARQYA GLDHELAFSR 
    LIVELRRLHP GHVLPDEELQ WVFVNAGGWM GAMCLLHASL SEGDGSTRAW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.