SAP18 | ENSG00000150459 | NCBI 10284

Details for: SAP18

Gene ID: 10284

Symbol: SAP18

Ensembl ID: ENSG00000150459

Description: Sin3A associated protein 18

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Disease
(R-HSA-1643685)
Epigenetic regulation of gene expression
(R-HSA-212165)
Gene expression (transcription)
(R-HSA-74160)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Potential therapeutics for sars
(R-HSA-9679191)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Asap complex
(GO:0061574)
Cytosol
(GO:0005829)
Exon-exon junction complex
(GO:0035145)
Histone deacetylase complex
(GO:0000118)
Mrna processing
(GO:0006397)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of mrna splicing, via spliceosome
(GO:0048025)
Nuclear body
(GO:0016604)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)

Other Information

Proteins

Histone deacetylase complex subunit SAP18

Genular Protein ID: 1143955733

Symbol: SAP18_HUMAN

Name: Histone deacetylase complex subunit SAP18

UniProtKB Accession Codes:

O00422 B2R494 Q2TTR4 Q6IAW9 Q8N606 Q9UF14 X6RAL5

Database IDs:

Citations:

PubMed ID: 9150135

Title: Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.

PubMed ID: 9150135

DOI: 10.1016/s0092-8674(00)80216-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665594

Title: ASAP, a novel protein complex involved in RNA processing and apoptosis.

PubMed ID: 12665594

DOI: 10.1128/mcb.23.8.2981-2990.2003

PubMed ID: 16314458

Title: Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

PubMed ID: 16314458

DOI: 10.1261/rna.2155905

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20966198

Title: Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.

PubMed ID: 20966198

DOI: 10.1261/rna.2304410

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22203037

Title: Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.

PubMed ID: 22203037

DOI: 10.1128/mcb.06130-11

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17002296

Title: Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.

PubMed ID: 17002296

DOI: 10.1021/bi060687l

Sequence Information:

Length: 153
Mass: 17561
Checksum: C7E479FFE9CA5774
Sequence:

MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT 
WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM 
TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SAP18

Associated with

Other Information

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. PubMed ID: 9150135

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ASAP, a novel protein complex involved in RNA processing and apoptosis. PubMed ID: 12665594

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. PubMed ID: 16314458

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. PubMed ID: 20966198

Initial characterization of the human central proteome. PubMed ID: 21269460

Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. PubMed ID: 22203037

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. PubMed ID: 17002296