BCAS2 | ENSG00000116752 | NCBI 10286

Details for: BCAS2

Gene ID: 10286

Symbol: BCAS2

Ensembl ID: ENSG00000116752

Description: BCAS2 pre-mRNA processing factor

Associated with

Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Catalytic step 2 spliceosome
(GO:0071013)
Centrosome
(GO:0005813)
Dna replication factor a complex
(GO:0005662)
Mrna splicing, via spliceosome
(GO:0000398)
Nuclear speck
(GO:0016607)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Prp19 complex
(GO:0000974)
Rna splicing
(GO:0008380)
Rna splicing, via transesterification reactions
(GO:0000375)
Spliceosomal complex
(GO:0005681)
U2-type catalytic step 2 spliceosome
(GO:0071007)

Other Information

Proteins

Pre-mRNA-splicing factor SPF27

Genular Protein ID: 1927737993

Symbol: SPF27_HUMAN

Name: Pre-mRNA-splicing factor SPF27

UniProtKB Accession Codes:

O75934 Q6FGS0

Database IDs:

Citations:

PubMed ID: 9731529

Title: Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.

PubMed ID: 9731529

DOI: 10.1038/1700

PubMed ID: 10403562

Title: Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines.

PubMed ID: 10403562

DOI: 10.1016/s0304-3835(99)00091-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12169396

Title: Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer.

PubMed ID: 12169396

DOI: 10.1016/s0304-3835(02)00286-0

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20176811

Title: Molecular architecture of the human Prp19/CDC5L complex.

PubMed ID: 20176811

DOI: 10.1128/mcb.01505-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24332808

Title: PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

PubMed ID: 24332808

DOI: 10.1016/j.molcel.2013.11.002

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 29301961

Title: Structure of a human catalytic step I spliceosome.

PubMed ID: 29301961

DOI: 10.1126/science.aar6401

PubMed ID: 30705154

Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

PubMed ID: 30705154

DOI: 10.1126/science.aaw5569

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 225
Mass: 26131
Checksum: 9112718EEFD96890
Sequence:

MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL SYLTAPDYSA 
FETDIMRNEF ERLAARQPIE LLSMKRYELP APSSGQKNDI TAWQECVNNS MAQLEHQAVR 
IENLELMSQH GCNAWKVYNE NLVHMIEHAQ KELQKLRKHI QDLNWQRKNM QLTAGSKLRE 
MESNWVSLVS KNYEIERTIV QLENEIYQIK QQHGEANKEN IRQDF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCAS2

Associated with

Other Information

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. PubMed ID: 9731529

Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines. PubMed ID: 10403562

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer. PubMed ID: 12169396

Functional proteomic analysis of human nucleolus. PubMed ID: 12429849

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Molecular architecture of the human Prp19/CDC5L complex. PubMed ID: 20176811

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. PubMed ID: 24332808

An Atomic Structure of the Human Spliceosome. PubMed ID: 28502770

Cryo-EM structure of a human spliceosome activated for step 2 of splicing. PubMed ID: 28076346

Structure of the human activated spliceosome in three conformational states. PubMed ID: 29360106

Structure of a human catalytic step I spliceosome. PubMed ID: 29301961

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. PubMed ID: 30705154

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974