Details for: RGS19

Gene ID: 10287

Symbol: RGS19

Ensembl ID: ENSG00000171700

Description: regulator of G protein signaling 19

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.61
    Marker Score: 5,080
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.45
    Marker Score: 137,269
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.13
    Marker Score: 2,561
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.1
    Marker Score: 24,384
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.09
    Marker Score: 5,193
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.01
    Marker Score: 1,889
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.94
    Marker Score: 3,374
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.91
    Marker Score: 12,228
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.85
    Marker Score: 1,864
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.84
    Marker Score: 4,443
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.72
    Marker Score: 17,443
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.72
    Marker Score: 4,672
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.69
    Marker Score: 1,725
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.62
    Marker Score: 1,450
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.6
    Marker Score: 41,031
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.55
    Marker Score: 943
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.54
    Marker Score: 927
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.53
    Marker Score: 4,550
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.52
    Marker Score: 15,099
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.5
    Marker Score: 6,157
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.5
    Marker Score: 1,135
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.5
    Marker Score: 824
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.47
    Marker Score: 2,160
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.46
    Marker Score: 4,601
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.44
    Marker Score: 331
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.42
    Marker Score: 1,243
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.4
    Marker Score: 4,082
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.4
    Marker Score: 1,598
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.39
    Marker Score: 1,383
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.38
    Marker Score: 3,364
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.37
    Marker Score: 5,884
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.36
    Marker Score: 3,517
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.33
    Marker Score: 469
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.32
    Marker Score: 1,320
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.29
    Marker Score: 528
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.29
    Marker Score: 630
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.28
    Marker Score: 551
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.27
    Marker Score: 1,231
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.23
    Marker Score: 2,410
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.18
    Marker Score: 693
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.17
    Marker Score: 578
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.16
    Marker Score: 843
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.16
    Marker Score: 1,988
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.15
    Marker Score: 6,989
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.13
    Marker Score: 780
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.13
    Marker Score: 1,002
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4,715
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.09
    Marker Score: 723
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.09
    Marker Score: 57,445
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.06
    Marker Score: 251
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.05
    Marker Score: 770
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.05
    Marker Score: 763
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.04
    Marker Score: 520
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.03
    Marker Score: 513
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.02
    Marker Score: 747
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.01
    Marker Score: 1,813
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.01
    Marker Score: 354
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1
    Marker Score: 817
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,695
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,920
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.98
    Marker Score: 650
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.97
    Marker Score: 909
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.95
    Marker Score: 241
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.95
    Marker Score: 936
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14,821
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,397
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.94
    Marker Score: 308
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.93
    Marker Score: 2,610
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.92
    Marker Score: 234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,702
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.9
    Marker Score: 651
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.89
    Marker Score: 849
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.89
    Marker Score: 1,177
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.88
    Marker Score: 305
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.88
    Marker Score: 352
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,238
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 519
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.86
    Marker Score: 360
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.85
    Marker Score: 501
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.85
    Marker Score: 3,542
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.85
    Marker Score: 523
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,830
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.84
    Marker Score: 2,319
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.83
    Marker Score: 360
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.83
    Marker Score: 403
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.82
    Marker Score: 406
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.81
    Marker Score: 194
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.81
    Marker Score: 251
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.81
    Marker Score: 279
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.8
    Marker Score: 582
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.8
    Marker Score: 331
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.8
    Marker Score: 439
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.78
    Marker Score: 526
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.78
    Marker Score: 1,422
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.78
    Marker Score: 1,100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS19 is a small GTPase-activating protein (GAP) that specifically targets Gα proteins, thereby accelerating their GTPase activity and negatively regulating GPCR signaling. This gene is highly expressed in immune cells, including CD14+ and CD16+ monocytes, B cells, and T cells, suggesting its critical role in immune responses. RGS19 also interacts with other proteins, such as clathrin and GPCRs, to modulate membrane trafficking and signaling. **Pathways and Functions:** RGS19 is involved in various signaling pathways, including: 1. **G-protein alpha-subunit binding**: RGS19 specifically binds to Gα proteins, accelerating their GTPase activity and terminating GPCR signaling. 2. **Autophagy**: RGS19 interacts with autophagy-related proteins to regulate the autophagic process, which is essential for cellular homeostasis and stress response. 3. **GPCR downstream signaling**: RGS19 negatively regulates GPCR signaling, influencing the activation of downstream effectors, such as adenylate cyclase and phospholipase C. 4. **Golgi apparatus**: RGS19 is involved in regulating membrane trafficking and protein sorting in the Golgi apparatus. **Clinical Significance:** RGS19's dysregulation has been implicated in various diseases, including: 1. **Immune disorders**: RGS19's role in regulating immune cell signaling and function makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: RGS19's involvement in autophagy and GPCR signaling pathways suggests its potential role in cancer progression and metastasis. 3. **Neurological disorders**: RGS19's interaction with GPCRs and its role in regulating membrane trafficking may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RGS19 is a multifaceted gene that plays a critical role in regulating G-protein signaling, autophagy, and membrane trafficking. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the functional significance of RGS19 in different physiological and pathological contexts.

Genular Protein ID: 1802483871

Symbol: RGS19_HUMAN

Name: Regulator of G-protein signaling 19

UniProtKB Accession Codes:

P49795 A8K216 E1P5G9 Q53XN0 Q8TD60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524874

Title: GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

PubMed ID: 8524874

DOI: 10.1073/pnas.92.25.11916

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8986788

Title: GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.

PubMed ID: 8986788

DOI: 10.1073/pnas.93.26.15203

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10452897

Title: Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling.

PubMed ID: 10452897

DOI: 10.1006/jmbi.1999.2989

PubMed ID: 9748280

Title: RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily.

PubMed ID: 9748280

DOI: 10.1074/jbc.273.40.26014

PubMed ID: 10993892

Title: Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.

PubMed ID: 10993892

DOI: 10.1074/jbc.m006198200

PubMed ID: 34685729

Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.

PubMed ID: 34685729

DOI: 10.3390/cells10102749

Sequence Information:

  • Length: 217
  • Mass: 24636
  • Checksum: 925A5687DC222CBD
  • Sequence:
    • MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS WNQERRRAWQ 
ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG RSVFRAFLRT EYSEENMLFW 
LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINKKMQ EPSAHTFDDA 
QLQIYTLMHR DSYPRFLSSP TYRALLLQGP SQSSSEA

Genular Protein ID: 569539816

Symbol: B4DP94_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DP94

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 195
  • Mass: 22236
  • Checksum: 3BF3EEFDA3B8B0DF
  • Sequence:
    • MSSHDTASPA APSRNPCCLC WCCCCSCSWN QERRRAWQAS RESKLQPLPS CEVCATPSPE 
EVQSWAQSFD KLMHSPAGRS VFRAFLRTEY SEENMLFWLA CEELKAEANQ HVVDEKARLI 
YEDYVSILSP KEVSLDSRVR EGINKKMQEP SAHTFDDAQL QIYTLMHRDS YPRFLSSPTY 
RALLLQGPSQ SSSEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.