LILRB2 | ENSG00000131042 | NCBI 10288

Details for: LILRB2

Gene ID: 10288

Symbol: LILRB2

Ensembl ID: ENSG00000131042

Description: leukocyte immunoglobulin like receptor B2

Associated with

Adaptive immune system
(R-HSA-1280218)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Adaptive immune response
(GO:0002250)
Amyloid-beta binding
(GO:0001540)
Cell-cell signaling
(GO:0007267)
Cell adhesion molecule binding
(GO:0050839)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular defense response
(GO:0006968)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Extracellular space
(GO:0005615)
Fc receptor mediated inhibitory signaling pathway
(GO:0002774)
Ficolin-1-rich granule membrane
(GO:0101003)
Heterotypic cell-cell adhesion
(GO:0034113)
Immune response
(GO:0006955)
Immune response-inhibiting cell surface receptor signaling pathway
(GO:0002767)
Inhibitory mhc class i receptor activity
(GO:0032396)
Interleukin-10-mediated signaling pathway
(GO:0140105)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Mhc class ib protein binding
(GO:0023029)
Mhc class ib protein complex binding
(GO:0023025)
Mhc class i protein binding
(GO:0042288)
Negative regulation of antigen processing and presentation
(GO:0002578)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of postsynaptic density organization
(GO:1905875)
Negative regulation of protein metabolic process
(GO:0051248)
Negative regulation of t cell costimulation
(GO:2000524)
Negative regulation of t cell proliferation
(GO:0042130)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of long-term synaptic depression
(GO:1900454)
Positive regulation of protein dephosphorylation
(GO:0035307)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of t cell tolerance induction
(GO:0002666)
Positive regulation of tolerance induction
(GO:0002645)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphatase 1 binding
(GO:0008157)
Regulation of dendritic cell differentiation
(GO:2001198)
Regulation of long-term synaptic potentiation
(GO:1900271)
Signal transduction
(GO:0007165)
Tertiary granule membrane
(GO:0070821)

Other Information

Proteins

Leukocyte immunoglobulin-like receptor subfamily B member 2

Genular Protein ID: 725985408

Symbol: LIRB2_HUMAN

Name: Leukocyte immunoglobulin-like receptor subfamily B member 2

UniProtKB Accession Codes:

Q8N423 A2IXV5 A8MU67 C9JF29 O75017 Q8NHJ7 Q8NHJ8

Database IDs:

Citations:

PubMed ID: 9259559

Title: A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors.

PubMed ID: 9259559

DOI: 10.1016/s0960-9822(06)00263-6

PubMed ID: 9382880

Title: A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.

PubMed ID: 9382880

DOI: 10.1084/jem.186.11.1809

PubMed ID: 9548455

Title: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

PubMed ID: 9548455

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9842885

Title: The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.

PubMed ID: 9842885

DOI: 10.1002/(sici)1521-4141(199811)28:11<3423::aid-immu3423>3.0.co;2-2

PubMed ID: 11169396

Title: Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.

PubMed ID: 11169396

DOI: 10.1002/1521-4141(200012)30:12<3552::aid-immu3552>3.0.co;2-l

PubMed ID: 11875462

Title: Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.

PubMed ID: 11875462

DOI: 10.1038/ni760

PubMed ID: 12853576

Title: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.

PubMed ID: 12853576

DOI: 10.1073/pnas.1431057100

PubMed ID: 16455647

Title: Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

PubMed ID: 16455647

DOI: 10.1074/jbc.m512305200

PubMed ID: 19860908

Title: The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

PubMed ID: 19860908

DOI: 10.1186/1471-2172-10-56

PubMed ID: 20448110

Title: Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

PubMed ID: 20448110

DOI: 10.1182/blood-2009-07-234872

PubMed ID: 27859042

Title: HLA-G promotes myeloid-derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4.

PubMed ID: 27859042

DOI: 10.1002/eji.201646564

PubMed ID: 12390682

Title: Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18.

PubMed ID: 12390682

DOI: 10.1186/1472-6807-2-6

Sequence Information:

Length: 597
Mass: 65005
Checksum: F58D713858356427
Sequence:

MTPIVTVLIC LGLSLGPRTR VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ GSLEAQEYRL 
YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY YSRARWSELS DPLVLVMTGA 
YPKPTLSAQP SPVVTSGGRV TLQCESQVAF GGFILCKEGE DEHPQCLNSQ PHARGSSRAI 
FSVGPVSPNR RWSHRCYGYD LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVMAPGES 
LTLQCVSDVG YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH 
NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ FHTFLLTKAG 
AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL NSDPYLLSHP SEPLELVVSG 
PSMGSSPPPT GPISTPGPED QPLTPTGSDP QSGLGRHLGV VIGILVAVVL LLLLLLLLFL 
ILRHRRQGKH WTSTQRKADF QHPAGAVGPE PTDRGLQWRS SPAADAQEEN LYAAVKDTQP 
EDGVEMDTRA AASEAPQDVT YAQLHSLTLR RKATEPPPSQ EREPPAEPSI YATLAIH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LILRB2

Associated with

Other Information

A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. PubMed ID: 9259559

A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. PubMed ID: 9382880

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. PubMed ID: 9548455

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. PubMed ID: 9842885

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors. PubMed ID: 11169396

Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. PubMed ID: 11875462

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. PubMed ID: 12853576

Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer. PubMed ID: 16455647

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. PubMed ID: 19860908

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. PubMed ID: 20448110

HLA-G promotes myeloid-derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4. PubMed ID: 27859042

Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18. PubMed ID: 12390682