Details for: CDKN2A
Associated with
Other Information
Genular Protein ID: 401276940
Symbol: CDN2A_HUMAN
Name: Cyclin-dependent kinase 4 inhibitor A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8259215
Title: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
PubMed ID: 8259215
DOI: 10.1038/366704a0
PubMed ID: 10445844
Title: Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus.
PubMed ID: 10445844
PubMed ID: 12228235
Title: Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia.
PubMed ID: 12228235
PubMed ID: 17486064
Title: Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16(INK4A) in cancer cells and inhibits cell-cycle progression.
PubMed ID: 17486064
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 8622687
Title: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
PubMed ID: 8622687
DOI: 10.1128/mcb.16.3.859
PubMed ID: 8152487
Title: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.
PubMed ID: 8152487
DOI: 10.1038/368753a0
PubMed ID: 8153634
Title: A cell cycle regulator potentially involved in genesis of many tumor types.
PubMed ID: 8153634
PubMed ID: 7972006
Title: Mutations and altered expression of p16INK4 in human cancer.
PubMed ID: 7972006
PubMed ID: 12529334
Title: Phosphorylation of p16INK4A correlates with Cdk4 association.
PubMed ID: 12529334
PubMed ID: 16782892
Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.
PubMed ID: 16782892
DOI: 10.1128/mcb.02006-05
PubMed ID: 17658461
Title: Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.
PubMed ID: 17658461
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 9751050
Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
PubMed ID: 9751050
DOI: 10.1038/26155
PubMed ID: 10556039
Title: Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
PubMed ID: 10556039
PubMed ID: 10892805
Title: Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data.
PubMed ID: 10892805
DOI: 10.1110/ps.9.6.1120
PubMed ID: 8783570
Title: CDKN2 mutations in melanoma.
PubMed ID: 8783570
PubMed ID: 8723678
Title: CDKN2A (p16INK4A) somatic and germline mutations.
PubMed ID: 8723678
DOI: 10.1002/(sici)1098-1004(1996)7:4<294::aid-humu2>3.0.co;2-9
PubMed ID: 8060323
Title: Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.
PubMed ID: 8060323
PubMed ID: 7987387
PubMed ID: 7970734
Title: The MTS1 gene is frequently mutated in primary human esophageal tumors.
PubMed ID: 7970734
PubMed ID: 7882351
Title: Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.
PubMed ID: 7882351
PubMed ID: 8595405
Title: Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds.
PubMed ID: 8595405
PubMed ID: 7647780
Title: Mutations associated with familial melanoma impair p16INK4 function.
PubMed ID: 7647780
DOI: 10.1038/ng0595-114
PubMed ID: 8653684
Title: Novel germline p16 mutation in familial malignant melanoma in southern Sweden.
PubMed ID: 8653684
PubMed ID: 8710906
Title: Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.
PubMed ID: 8710906
PubMed ID: 9328469
Title: Germline mutations of the CDKN2 gene in UK melanoma families.
PubMed ID: 9328469
PubMed ID: 9425228
Title: Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France.
PubMed ID: 9425228
DOI: 10.1093/hmg/7.2.209
PubMed ID: 10651484
Title: Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas.
PubMed ID: 10651484
PubMed ID: 10484981
Title: Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.
PubMed ID: 10484981
PubMed ID: 11506491
Title: A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families.
PubMed ID: 11506491
PubMed ID: 11136714
Title: A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.
PubMed ID: 11136714
DOI: 10.1093/hmg/10.1.55
PubMed ID: 12019208
Title: Germline mutation of ARF in a melanoma kindred.
PubMed ID: 12019208
PubMed ID: 10874641
Title: CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasia.
PubMed ID: 10874641
PubMed ID: 12556369
Title: Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma.
PubMed ID: 12556369
DOI: 10.1167/iovs.02-0026
PubMed ID: 14646619
Title: A novel L94Q mutation in the CDKN2A gene in a melanoma kindred.
PubMed ID: 14646619
PubMed ID: 19260062
Title: Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.
PubMed ID: 19260062
DOI: 10.1002/humu.20845
Sequence Information:
- Length: 156
- Mass: 16533
- Checksum: E59C0E6174B48255
- Sequence:
MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD
Genular Protein ID: 4102692825
Symbol: ARF_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7606716
Title: Complex structure and regulation of the P16 (MTS1) locus.
PubMed ID: 7606716
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7624129
Title: A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.
PubMed ID: 7624129
PubMed ID: 9724636
Title: The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
PubMed ID: 9724636
PubMed ID: 11314011
Title: Human ARF protein interacts with topoisomerase I and stimulates its activity.
PubMed ID: 11314011
PubMed ID: 11314038
Title: Human ARF binds E2F1 and inhibits its transcriptional activity.
PubMed ID: 11314038
PubMed ID: 12154087
Title: CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.
PubMed ID: 12154087
PubMed ID: 12581788
Title: A novel putative collaborator of p19ARF.
PubMed ID: 12581788
PubMed ID: 12446718
Title: Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.
PubMed ID: 12446718
PubMed ID: 14636574
Title: Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.
PubMed ID: 14636574
PubMed ID: 12660818
Title: p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice.
PubMed ID: 12660818
PubMed ID: 15361825
Title: Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.
PubMed ID: 15361825
PubMed ID: 15567177
Title: The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.
PubMed ID: 15567177
PubMed ID: 15989956
Title: ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
PubMed ID: 15989956
PubMed ID: 15876874
Title: p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.
PubMed ID: 15876874
DOI: 10.4161/cc.4.4.1597
PubMed ID: 16173922
Title: A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.
PubMed ID: 16173922
DOI: 10.1042/bj20050960
PubMed ID: 16713577
Title: A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.
PubMed ID: 16713577
PubMed ID: 17110379
Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
PubMed ID: 17110379
PubMed ID: 17486078
Title: The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.
PubMed ID: 17486078
PubMed ID: 18305112
Title: Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1.
PubMed ID: 18305112
PubMed ID: 20208519
Title: Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.
PubMed ID: 20208519
DOI: 10.1038/nature08820
PubMed ID: 22094112
Title: A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF.
PubMed ID: 22094112
PubMed ID: 27323397
Title: GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.
PubMed ID: 27323397
Sequence Information:
- Length: 132
- Mass: 13903
- Checksum: 7739A9050C21BC96
- Sequence:
MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL RSQRLGQQPL PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC PGGLPGHAGG AAPGRGAAGR ARCLGPSARG PG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.