Details for: CDKN2A

Gene ID: 1029

Symbol: CDKN2A

Ensembl ID: ENSG00000147889

Description: cyclin dependent kinase inhibitor 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.1854
    Cell Significance Index: -16.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.1452
    Cell Significance Index: -16.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.0337
    Cell Significance Index: -16.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7670
    Cell Significance Index: -12.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1206
    Cell Significance Index: -16.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8228
    Cell Significance Index: -8.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3130
    Cell Significance Index: 67.9300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.0091
    Cell Significance Index: 28.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.2464
    Cell Significance Index: 10.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0798
    Cell Significance Index: 589.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8093
    Cell Significance Index: 17.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7034
    Cell Significance Index: 69.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6036
    Cell Significance Index: 545.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5018
    Cell Significance Index: 32.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4632
    Cell Significance Index: 50.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4526
    Cell Significance Index: 27.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4420
    Cell Significance Index: 84.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4238
    Cell Significance Index: 68.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3799
    Cell Significance Index: 10.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2814
    Cell Significance Index: 14.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2356
    Cell Significance Index: 16.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1969
    Cell Significance Index: 8.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1590
    Cell Significance Index: 28.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1225
    Cell Significance Index: 3.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1026
    Cell Significance Index: 11.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0868
    Cell Significance Index: 54.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0810
    Cell Significance Index: 9.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0711
    Cell Significance Index: 1.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0516
    Cell Significance Index: 1.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0343
    Cell Significance Index: 15.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0132
    Cell Significance Index: 4.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0008
    Cell Significance Index: 0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0010
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0097
    Cell Significance Index: -1.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0126
    Cell Significance Index: -23.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0142
    Cell Significance Index: -21.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0183
    Cell Significance Index: -24.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0192
    Cell Significance Index: -14.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0195
    Cell Significance Index: -14.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0198
    Cell Significance Index: -1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0203
    Cell Significance Index: -1.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0207
    Cell Significance Index: -2.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0216
    Cell Significance Index: -2.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0294
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0323
    Cell Significance Index: -5.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0341
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0361
    Cell Significance Index: -7.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0384
    Cell Significance Index: -17.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0424
    Cell Significance Index: -8.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0434
    Cell Significance Index: -5.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0511
    Cell Significance Index: -0.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0572
    Cell Significance Index: -0.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0662
    Cell Significance Index: -3.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0809
    Cell Significance Index: -2.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0887
    Cell Significance Index: -2.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0945
    Cell Significance Index: -13.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0993
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1004
    Cell Significance Index: -11.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1108
    Cell Significance Index: -4.5400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1139
    Cell Significance Index: -0.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1191
    Cell Significance Index: -7.3000
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.1195
    Cell Significance Index: -0.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1353
    Cell Significance Index: -6.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1502
    Cell Significance Index: -4.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1554
    Cell Significance Index: -16.1800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1619
    Cell Significance Index: -2.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1914
    Cell Significance Index: -2.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2017
    Cell Significance Index: -3.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2160
    Cell Significance Index: -12.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2183
    Cell Significance Index: -13.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2260
    Cell Significance Index: -17.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2261
    Cell Significance Index: -15.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2396
    Cell Significance Index: -6.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2512
    Cell Significance Index: -8.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2600
    Cell Significance Index: -15.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2742
    Cell Significance Index: -12.7900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2746
    Cell Significance Index: -3.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3439
    Cell Significance Index: -9.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3688
    Cell Significance Index: -4.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3753
    Cell Significance Index: -9.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3972
    Cell Significance Index: -17.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3980
    Cell Significance Index: -9.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4138
    Cell Significance Index: -2.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4271
    Cell Significance Index: -15.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4306
    Cell Significance Index: -11.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4436
    Cell Significance Index: -14.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4512
    Cell Significance Index: -14.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4637
    Cell Significance Index: -4.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4760
    Cell Significance Index: -18.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4782
    Cell Significance Index: -10.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5157
    Cell Significance Index: -15.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5320
    Cell Significance Index: -13.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5340
    Cell Significance Index: -15.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5555
    Cell Significance Index: -14.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell cycle regulation**: CDKN2A inhibits CDKs, which are essential for the progression of the cell cycle. By inhibiting CDKs, CDKN2A prevents the phosphorylation of pRb, thereby regulating cell cycle progression. 2. **Apoptosis regulation**: CDKN2A can induce apoptosis in response to DNA damage or other forms of cellular stress. 3. **Senescence regulation**: CDKN2A is involved in the regulation of cellular senescence, a state of permanent cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. 4. **Oxidative stress response**: CDKN2A can regulate the response to oxidative stress by modulating the activity of p53, a key transcription factor involved in the response to DNA damage. **Pathways and Functions** 1. **Apoptosis pathway**: CDKN2A can induce apoptosis in response to DNA damage or other forms of cellular stress. 2. **Cell cycle checkpoint**: CDKN2A regulates the G1/S transition of the cell cycle by inhibiting CDKs. 3. **Senescence pathway**: CDKN2A is involved in the regulation of cellular senescence, a state of permanent cell cycle arrest. 4. **Oxidative stress response**: CDKN2A can regulate the response to oxidative stress by modulating the activity of p53. 5. **DNA damage response**: CDKN2A can regulate the response to DNA damage by modulating the activity of p53 and other transcription factors. **Clinical Significance** 1. **Cancer risk**: Mutations or deletions in the CDKN2A gene have been associated with an increased risk of developing various cancers, including melanoma, pancreatic cancer, and breast cancer. 2. **Prognostic marker**: CDKN2A can serve as a prognostic marker for patients with cancer, particularly those with melanoma and pancreatic cancer. 3. **Therapeutic target**: CDKN2A can be a therapeutic target for the treatment of cancer, particularly those with mutations or deletions in the CDKN2A gene. 4. **Neurological disorders**: CDKN2A has been implicated in the pathogenesis of various neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, the CDKN2A gene plays a crucial role in regulating the cell cycle, apoptosis, and cellular responses to stress. Mutations or deletions in the CDKN2A gene have been associated with an increased risk of developing various cancers, and CDKN2A can serve as a prognostic marker and therapeutic target for patients with cancer. Additionally, CDKN2A has been implicated in the pathogenesis of various neurological disorders.

Genular Protein ID: 4102692825

Symbol: ARF_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N726 D3DRK2 Q13195 Q13399 Q16360 Q7KZR9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 52 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IntAct 1 InterPro 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PIR 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 Reactome 12 RefSeq 1 SIGNOR 1 SignaLink 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7606716

Title: Complex structure and regulation of the P16 (MTS1) locus.

PubMed ID: 7606716

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7624129

Title: A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.

PubMed ID: 7624129

PubMed ID: 9724636

Title: The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

PubMed ID: 9724636

DOI: 10.1093/emboj/17.17.5001

PubMed ID: 11314011

Title: Human ARF protein interacts with topoisomerase I and stimulates its activity.

PubMed ID: 11314011

DOI: 10.1038/sj.onc.1204170

PubMed ID: 11314038

Title: Human ARF binds E2F1 and inhibits its transcriptional activity.

PubMed ID: 11314038

DOI: 10.1038/sj.onc.1204220

PubMed ID: 12154087

Title: CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.

PubMed ID: 12154087

DOI: 10.1074/jbc.m204177200

PubMed ID: 12581788

Title: A novel putative collaborator of p19ARF.

PubMed ID: 12581788

DOI: 10.1016/s0531-5565(02)00180-8

PubMed ID: 12446718

Title: Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.

PubMed ID: 12446718

DOI: 10.1074/jbc.m210978200

PubMed ID: 14636574

Title: Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

PubMed ID: 14636574

DOI: 10.1016/s1097-2765(03)00431-3

PubMed ID: 12660818

Title: p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice.

PubMed ID: 12660818

DOI: 10.1038/sj.onc.1206303

PubMed ID: 15361825

Title: Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.

PubMed ID: 15361825

DOI: 10.1038/sj.onc.1207968

PubMed ID: 15567177

Title: The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.

PubMed ID: 15567177

DOI: 10.1016/j.bbrc.2004.11.016

PubMed ID: 15989956

Title: ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.

PubMed ID: 15989956

DOI: 10.1016/j.cell.2005.03.037

PubMed ID: 15876874

Title: p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.

PubMed ID: 15876874

DOI: 10.4161/cc.4.4.1597

PubMed ID: 16173922

Title: A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.

PubMed ID: 16173922

DOI: 10.1042/bj20050960

PubMed ID: 16713577

Title: A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.

PubMed ID: 16713577

DOI: 10.1016/j.molcel.2006.04.014

PubMed ID: 17110379

Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

PubMed ID: 17110379

DOI: 10.1074/jbc.m609612200

PubMed ID: 17486078

Title: The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.

PubMed ID: 17486078

DOI: 10.1038/sj.onc.1210485

PubMed ID: 18305112

Title: Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1.

PubMed ID: 18305112

DOI: 10.1074/jbc.m708544200

PubMed ID: 20208519

Title: Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.

PubMed ID: 20208519

DOI: 10.1038/nature08820

PubMed ID: 22094112

Title: A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF.

PubMed ID: 22094112

DOI: 10.1016/j.yexcr.2011.10.019

PubMed ID: 27323397

Title: GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.

PubMed ID: 27323397

DOI: 10.18632/oncotarget.9957

Sequence Information:

  • Length: 132
  • Mass: 13903
  • Checksum: 7739A9050C21BC96
  • Sequence:
    • MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL RSQRLGQQPL 
PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC PGGLPGHAGG AAPGRGAAGR 
ARCLGPSARG PG

Genular Protein ID: 401276940

Symbol: CDN2A_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor A

UniProtKB Accession Codes:

P42771 A5X2G7 D3DRK1 G3XAG3 O95440 Q15191 Q5VVJ5 Q96B52 Q9NP05

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 10 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8259215

Title: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

PubMed ID: 8259215

DOI: 10.1038/366704a0

PubMed ID: 10445844

Title: Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus.

PubMed ID: 10445844

DOI: 10.1038/sj.onc.1202737

PubMed ID: 12228235

Title: Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia.

PubMed ID: 12228235

DOI: 10.1074/jbc.m208353200

PubMed ID: 17486064

Title: Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16(INK4A) in cancer cells and inhibits cell-cycle progression.

PubMed ID: 17486064

DOI: 10.1038/sj.onc.1210507

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 8622687

Title: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.

PubMed ID: 8622687

DOI: 10.1128/mcb.16.3.859

PubMed ID: 8152487

Title: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.

PubMed ID: 8152487

DOI: 10.1038/368753a0

PubMed ID: 8153634

Title: A cell cycle regulator potentially involved in genesis of many tumor types.

PubMed ID: 8153634

DOI: 10.1126/science.8153634

PubMed ID: 7972006

Title: Mutations and altered expression of p16INK4 in human cancer.

PubMed ID: 7972006

DOI: 10.1073/pnas.91.23.11045

PubMed ID: 12529334

Title: Phosphorylation of p16INK4A correlates with Cdk4 association.

PubMed ID: 12529334

DOI: 10.1074/jbc.c200622200

PubMed ID: 16782892

Title: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'.

PubMed ID: 16782892

DOI: 10.1128/mcb.02006-05

PubMed ID: 17658461

Title: Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.

PubMed ID: 17658461

DOI: 10.1016/j.bbrc.2007.06.181

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 9751050

Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

PubMed ID: 9751050

DOI: 10.1038/26155

PubMed ID: 10556039

Title: Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).

PubMed ID: 10556039

DOI: 10.1006/jmbi.1999.3231

PubMed ID: 10892805

Title: Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data.

PubMed ID: 10892805

DOI: 10.1110/ps.9.6.1120

PubMed ID: 8783570

Title: CDKN2 mutations in melanoma.

PubMed ID: 8783570

PubMed ID: 8723678

Title: CDKN2A (p16INK4A) somatic and germline mutations.

PubMed ID: 8723678

DOI: 10.1002/(sici)1098-1004(1996)7:4<294::aid-humu2>3.0.co;2-9

PubMed ID: 8060323

Title: Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.

PubMed ID: 8060323

DOI: 10.1006/bbrc.1994.2090

PubMed ID: 7987387

Title: Germline p16 mutations in familial melanoma.

PubMed ID: 7987387

DOI: 10.1038/ng0994-15

PubMed ID: 7970734

Title: The MTS1 gene is frequently mutated in primary human esophageal tumors.

PubMed ID: 7970734

PubMed ID: 7882351

Title: Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.

PubMed ID: 7882351

PubMed ID: 8595405

Title: Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds.

PubMed ID: 8595405

DOI: 10.1093/hmg/4.10.1845

PubMed ID: 7647780

Title: Mutations associated with familial melanoma impair p16INK4 function.

PubMed ID: 7647780

DOI: 10.1038/ng0595-114

PubMed ID: 8653684

Title: Novel germline p16 mutation in familial malignant melanoma in southern Sweden.

PubMed ID: 8653684

PubMed ID: 8710906

Title: Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.

PubMed ID: 8710906

DOI: 10.1073/pnas.93.16.8541

PubMed ID: 9328469

Title: Germline mutations of the CDKN2 gene in UK melanoma families.

PubMed ID: 9328469

DOI: 10.1093/hmg/6.12.2061

PubMed ID: 9425228

Title: Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France.

PubMed ID: 9425228

DOI: 10.1093/hmg/7.2.209

PubMed ID: 10651484

Title: Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas.

PubMed ID: 10651484

PubMed ID: 10484981

Title: Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.

PubMed ID: 10484981

DOI: 10.1016/s0165-4608(98)00276-3

PubMed ID: 11506491

Title: A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families.

PubMed ID: 11506491

DOI: 10.1054/bjoc.2001.1944

PubMed ID: 11136714

Title: A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.

PubMed ID: 11136714

DOI: 10.1093/hmg/10.1.55

PubMed ID: 12019208

Title: Germline mutation of ARF in a melanoma kindred.

PubMed ID: 12019208

DOI: 10.1093/hmg/11.11.1273

PubMed ID: 10874641

Title: CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasia.

PubMed ID: 10874641

PubMed ID: 12556369

Title: Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma.

PubMed ID: 12556369

DOI: 10.1167/iovs.02-0026

PubMed ID: 14646619

Title: A novel L94Q mutation in the CDKN2A gene in a melanoma kindred.

PubMed ID: 14646619

DOI: 10.1097/01.cmr.0000056289.15046.c0

PubMed ID: 19260062

Title: Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.

PubMed ID: 19260062

DOI: 10.1002/humu.20845

Sequence Information:

  • Length: 156
  • Mass: 16533
  • Checksum: E59C0E6174B48255
  • Sequence:
    • MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 
ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 
LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.