Details for: PAK4
Associated with
Other Information
Genular Protein ID: 1572122299
Symbol: PAK4_HUMAN
Name: Serine/threonine-protein kinase PAK 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9822598
Title: PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
PubMed ID: 9822598
PubMed ID: 10574461
Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
PubMed ID: 10574461
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11278822
Title: The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.
PubMed ID: 11278822
PubMed ID: 11313478
Title: Activated PAK4 regulates cell adhesion and anchorage-independent growth.
PubMed ID: 11313478
PubMed ID: 12356872
Title: P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration.
PubMed ID: 12356872
PubMed ID: 14560027
Title: Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4.
PubMed ID: 14560027
PubMed ID: 15660133
Title: Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.
PubMed ID: 15660133
PubMed ID: 15827085
Title: PAK4 mediates morphological changes through the regulation of GEF-H1.
PubMed ID: 15827085
DOI: 10.1242/jcs.02313
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20507994
Title: p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration.
PubMed ID: 20507994
PubMed ID: 20805321
Title: Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis.
PubMed ID: 20805321
PubMed ID: 20631255
Title: Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.
PubMed ID: 20631255
PubMed ID: 11950587
Title: p21-activated kinases: three more join the Pak.
PubMed ID: 11950587
PubMed ID: 20070256
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24130170
Title: SH3RF2 functions as an oncogene by mediating PAK4 protein stability.
PubMed ID: 24130170
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 30189201
Title: Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6.
PubMed ID: 30189201
PubMed ID: 26607847
Title: An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1.
PubMed ID: 26607847
DOI: 10.1038/ncomms9681
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 591
- Mass: 64072
- Checksum: 04C2A5C0B06427D5
- Sequence:
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPEE PATTARGGPG KAGSRGRFAG HSEAGGGSGD RRRAGPEKRP KSSREGSGGP QESSRDKRPL SGPDVGTPQP AGLASGAKLA AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGGLAIP QSSSSSSRPP TRARGAPSPG VLGPHASEPQ LAPPACTPAA PAVPGPPGPR SPQREPQRVS HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGKLVAVK KMDLRKQQRR ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIAAV CLAVLQALSV LHAQGVIHRD IKSDSILLTH DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY WMAPELISRL PYGPEVDIWS LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK VSPSLKGFLD RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.