Details for: CDKN2B

Gene ID: 1030

Symbol: CDKN2B

Ensembl ID: ENSG00000147883

Description: cyclin dependent kinase inhibitor 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.7830
    Cell Significance Index: -9.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.8306
    Cell Significance Index: 173.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6919
    Cell Significance Index: -9.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6743
    Cell Significance Index: 190.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.6559
    Cell Significance Index: 54.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1573
    Cell Significance Index: 30.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9146
    Cell Significance Index: 41.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8319
    Cell Significance Index: 52.7800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4779
    Cell Significance Index: 12.7000
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.4508
    Cell Significance Index: 10.4400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1771
    Cell Significance Index: 7.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1455
    Cell Significance Index: 68.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1056
    Cell Significance Index: 210.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9908
    Cell Significance Index: 894.6200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.8480
    Cell Significance Index: 9.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8345
    Cell Significance Index: 90.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5511
    Cell Significance Index: 89.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5395
    Cell Significance Index: 8.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4929
    Cell Significance Index: 17.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4507
    Cell Significance Index: 31.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3945
    Cell Significance Index: 39.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2336
    Cell Significance Index: 14.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2156
    Cell Significance Index: 1.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1600
    Cell Significance Index: 18.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1578
    Cell Significance Index: 3.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1542
    Cell Significance Index: 4.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1330
    Cell Significance Index: 3.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1167
    Cell Significance Index: 63.7200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0990
    Cell Significance Index: 1.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0782
    Cell Significance Index: 0.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0746
    Cell Significance Index: 8.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0629
    Cell Significance Index: 1.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0605
    Cell Significance Index: 7.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0567
    Cell Significance Index: 25.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0451
    Cell Significance Index: 1.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0319
    Cell Significance Index: 0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0228
    Cell Significance Index: 4.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0197
    Cell Significance Index: 0.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0187
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0170
    Cell Significance Index: 2.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0148
    Cell Significance Index: 0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0105
    Cell Significance Index: 1.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0072
    Cell Significance Index: 1.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0034
    Cell Significance Index: -2.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -3.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0111
    Cell Significance Index: -1.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0133
    Cell Significance Index: -8.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0139
    Cell Significance Index: -0.1900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0183
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0186
    Cell Significance Index: -2.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0195
    Cell Significance Index: -1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0195
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0205
    Cell Significance Index: -4.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0207
    Cell Significance Index: -7.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0218
    Cell Significance Index: -9.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0247
    Cell Significance Index: -2.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0302
    Cell Significance Index: -8.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0364
    Cell Significance Index: -1.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0445
    Cell Significance Index: -8.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0584
    Cell Significance Index: -8.4900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0627
    Cell Significance Index: -0.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0666
    Cell Significance Index: -1.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0833
    Cell Significance Index: -9.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0842
    Cell Significance Index: -5.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0887
    Cell Significance Index: -6.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0901
    Cell Significance Index: -9.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0944
    Cell Significance Index: -2.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0970
    Cell Significance Index: -2.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1105
    Cell Significance Index: -8.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1124
    Cell Significance Index: -1.3400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1166
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1244
    Cell Significance Index: -9.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1399
    Cell Significance Index: -9.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1417
    Cell Significance Index: -9.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1426
    Cell Significance Index: -1.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1437
    Cell Significance Index: -2.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1457
    Cell Significance Index: -7.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1489
    Cell Significance Index: -3.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1515
    Cell Significance Index: -9.3100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1612
    Cell Significance Index: -1.0000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1620
    Cell Significance Index: -2.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1623
    Cell Significance Index: -9.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1882
    Cell Significance Index: -6.9100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1996
    Cell Significance Index: -0.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2141
    Cell Significance Index: -7.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2150
    Cell Significance Index: -11.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2190
    Cell Significance Index: -5.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2190
    Cell Significance Index: -5.8600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2201
    Cell Significance Index: -1.3600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2264
    Cell Significance Index: -3.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2354
    Cell Significance Index: -4.3500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2470
    Cell Significance Index: -3.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Cycle Regulation:** CDKN2B inhibits cyclin-dependent kinases, which are essential for cell cycle progression. The CDKN2B protein binds to and inhibits the activity of cyclin-dependent kinases, thereby regulating the G1/S transition and preventing unchecked cell proliferation. 2. **Negative Regulation of Cell Proliferation:** CDKN2B is a negative regulator of cell population proliferation, which means it prevents excessive cell growth and division. This function is critical in maintaining tissue homeostasis and preventing cancer. 3. **Tissue-Specific Expression:** CDKN2B is expressed in various epithelial tissues, including the respiratory tract, skin, and gastrointestinal tract. Its expression is also observed in cells of the immune system, such as T cells and macrophages. 4. **Interaction with Other Signaling Pathways:** CDKN2B interacts with various signaling pathways, including the TGF-β pathway, the PI3K/AKT pathway, and the MAPK/ERK pathway. These interactions regulate cellular responses to stimuli, including growth factors, cytokines, and stress signals. **Pathways and Functions:** 1. **Cell Cycle Regulation:** CDKN2B regulates the G1/S transition by inhibiting cyclin-dependent kinases. This function is critical in preventing unchecked cell proliferation and maintaining tissue homeostasis. 2. **Negative Regulation of Cell Proliferation:** CDKN2B prevents excessive cell growth and division by inhibiting cyclin-dependent kinases. 3. **Tissue-Specific Expression:** CDKN2B is expressed in epithelial tissues, where it regulates cell proliferation and differentiation. 4. **Signaling Pathway Regulation:** CDKN2B interacts with various signaling pathways, including the TGF-β pathway, the PI3K/AKT pathway, and the MAPK/ERK pathway. These interactions regulate cellular responses to stimuli, including growth factors, cytokines, and stress signals. 5. **Oncogene-Induced Senescence:** CDKN2B is involved in oncogene-induced senescence, a process by which cells become senescent in response to oncogenic stress. **Clinical Significance:** 1. **Cancer Association:** CDKN2B is associated with various cancers, including melanoma, pancreatic cancer, and breast cancer. Its dysregulation has been implicated in tumorigenesis and cancer progression. 2. **Disease Association:** CDKN2B has been associated with various diseases, including type 2 diabetes, cardiovascular disease, and neurodegenerative disorders. 3. **Cancer Therapy:** CDKN2B is a potential target for cancer therapy, as its inhibition can promote cell cycle arrest and apoptosis in cancer cells. 4. **Translational Research:** CDKN2B has been studied in various translational research contexts, including cancer research, immunology, and regenerative medicine. In conclusion, CDKN2B is a crucial regulator of cell cycle and cellular responses to stimuli. Its dysregulation has been implicated in various cancers and diseases, making it a potential target for cancer therapy and translational research. Further study of CDKN2B is necessary to fully understand its functions and clinical significance.

Genular Protein ID: 1561984660

Symbol: CDN2B_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor B

UniProtKB Accession Codes:

P42772 O15125 Q6FI09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8001816

Title: Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

PubMed ID: 8001816

DOI: 10.1101/gad.8.24.2939

PubMed ID: 8078588

Title: p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

PubMed ID: 8078588

DOI: 10.1038/371257a0

PubMed ID: 9230210

Title: Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor.

PubMed ID: 9230210

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8153634

Title: A cell cycle regulator potentially involved in genesis of many tumor types.

PubMed ID: 8153634

DOI: 10.1126/science.8153634

PubMed ID: 10892805

Title: Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data.

PubMed ID: 10892805

DOI: 10.1110/ps.9.6.1120

PubMed ID: 7882351

Title: Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.

PubMed ID: 7882351

Sequence Information:

  • Length: 138
  • Mass: 14722
  • Checksum: 0D6FFBDFA6FEAD21
  • Sequence:
    • MREENKGMPS GGGSDEGLAS AAARGLVEKV RQLLEAGADP NGVNRFGRRA IQVMMMGSAR 
VAELLLLHGA EPNCADPATL TRPVHDAARE GFLDTLVVLH RAGARLDVRD AWGRLPVDLA 
EERGHRDVAG YLRTATGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.