CDKN2B | ENSG00000147883 | NCBI 1030

Details for: CDKN2B

Gene ID: 1030

Symbol: CDKN2B

Ensembl ID: ENSG00000147883

Description: cyclin dependent kinase inhibitor 2B

Associated with

Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cyclin d associated events in g1
(R-HSA-69231)
G1 phase
(R-HSA-69236)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Cell cycle
(GO:0007049)
Cellular response to extracellular stimulus
(GO:0031668)
Cellular response to nutrient
(GO:0031670)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular senescence
(GO:0090398)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Liver development
(GO:0001889)
Megakaryocyte differentiation
(GO:0030219)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of phosphorylation
(GO:0042326)
Nucleus
(GO:0005634)
Positive regulation of epithelial cell differentiation
(GO:0030858)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of g0 to g1 transition
(GO:0070316)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Response to cytokine
(GO:0034097)
Response to organic cyclic compound
(GO:0014070)
Spleen development
(GO:0048536)

Other Information

Proteins

Cyclin-dependent kinase 4 inhibitor B

Genular Protein ID: 1561984660

Symbol: CDN2B_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor B

UniProtKB Accession Codes:

P42772 O15125 Q6FI09

Database IDs:

Citations:

PubMed ID: 8001816

Title: Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

PubMed ID: 8001816

DOI: 10.1101/gad.8.24.2939

PubMed ID: 8078588

Title: p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

PubMed ID: 8078588

DOI: 10.1038/371257a0

PubMed ID: 9230210

Title: Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor.

PubMed ID: 9230210

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8153634

Title: A cell cycle regulator potentially involved in genesis of many tumor types.

PubMed ID: 8153634

DOI: 10.1126/science.8153634

PubMed ID: 10892805

Title: Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data.

PubMed ID: 10892805

DOI: 10.1110/ps.9.6.1120

PubMed ID: 7882351

Title: Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.

PubMed ID: 7882351

Sequence Information:

Length: 138
Mass: 14722
Checksum: 0D6FFBDFA6FEAD21
Sequence:

MREENKGMPS GGGSDEGLAS AAARGLVEKV RQLLEAGADP NGVNRFGRRA IQVMMMGSAR 
VAELLLLHGA EPNCADPATL TRPVHDAARE GFLDTLVVLH RAGARLDVRD AWGRLPVDLA 
EERGHRDVAG YLRTATGD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN2B

Associated with

Other Information

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. PubMed ID: 8001816

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. PubMed ID: 8078588

Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor. PubMed ID: 9230210

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A cell cycle regulator potentially involved in genesis of many tumor types. PubMed ID: 8153634

Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. PubMed ID: 10892805

Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. PubMed ID: 7882351