KATNB1 | ENSG00000140854 | NCBI 10300

Details for: KATNB1

Gene ID: 10300

Symbol: KATNB1

Ensembl ID: ENSG00000140854

Description: katanin regulatory subunit B1

Associated with

Atpase regulator activity
(GO:0060590)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule organization
(GO:0031122)
Cytosol
(GO:0005829)
Dynein complex binding
(GO:0070840)
Growth cone
(GO:0030426)
Katanin complex
(GO:0008352)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule depolymerization
(GO:0007019)
Microtubule severing
(GO:0051013)
Midbody
(GO:0030496)
Mitotic chromosome movement towards spindle pole
(GO:0007079)
Negative regulation of microtubule depolymerization
(GO:0007026)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of microtubule depolymerization
(GO:0031117)
Positive regulation of neuron projection development
(GO:0010976)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein targeting
(GO:0006605)
Spindle
(GO:0005819)
Spindle pole
(GO:0000922)

Other Information

Proteins

KTNB1_HUMAN

Genular Protein ID: 3689110329

Symbol: KTNB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BVA0 A6NCG6 O60620

Database IDs:

Citations:

PubMed ID: 9568719

Title: Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.

PubMed ID: 9568719

DOI: 10.1016/s0092-8674(00)81578-0

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9658175

Title: Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.

PubMed ID: 9658175

DOI: 10.1091/mbc.9.7.1847

PubMed ID: 10751153

Title: Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.

PubMed ID: 10751153

DOI: 10.1242/jcs.113.9.1623

PubMed ID: 16203747

Title: Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.

PubMed ID: 16203747

DOI: 10.1093/hmg/ddi339

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24486153

Title: Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

PubMed ID: 24486153

DOI: 10.1016/j.devcel.2014.01.001

PubMed ID: 25521378

Title: Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors.

PubMed ID: 25521378

DOI: 10.1016/j.neuron.2014.12.014

PubMed ID: 26929214

Title: Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing.

PubMed ID: 26929214

DOI: 10.1074/mcp.m115.056465

PubMed ID: 25521379

Title: Katanin p80 regulates human cortical development by limiting centriole and cilia number.

PubMed ID: 25521379

DOI: 10.1016/j.neuron.2014.12.017

Sequence Information:

Length: 655
Mass: 72334
Checksum: 411903E306B6EC16
Sequence:

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 
ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK 
MMSEFPGHTG PVNVVEFHPN EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN 
PDGCCLYSGC QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV 
DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV KQNSESERRS 
PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS EPFPAPPEDD AATAKEAAKP 
SPAMDVQFPV PNLEVLPRPP VVASTPAPKA EPAIIPATRN EPIGLKASDF LPAVKIPQQA 
ELVDEDAMSQ IRKGHDTMCV VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL 
LNIVNQKASL WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP 
PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL MASLD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KATNB1

Associated with

Other Information

Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. PubMed ID: 9568719

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. PubMed ID: 9658175

Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. PubMed ID: 10751153

Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. PubMed ID: 16203747

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. PubMed ID: 24486153

Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. PubMed ID: 25521378

Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing. PubMed ID: 26929214

Katanin p80 regulates human cortical development by limiting centriole and cilia number. PubMed ID: 25521379