Details for: KATNB1

Gene ID: 10300

Symbol: KATNB1

Ensembl ID: ENSG00000140854

Description: katanin regulatory subunit B1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15,757
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,001
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 999
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.96
    Marker Score: 8,356
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2,183
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.89
    Marker Score: 1,368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,055
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,264
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.82
    Marker Score: 1,553
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8
    Marker Score: 251
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.76
    Marker Score: 6,559
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.76
    Marker Score: 3,124
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.75
    Marker Score: 45,994
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.74
    Marker Score: 7,035
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.7
    Marker Score: 642
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1,402
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 414
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,846
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.66
    Marker Score: 739
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 399
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.58
    Marker Score: 5,478
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 274
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.56
    Marker Score: 553
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 739
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.55
    Marker Score: 370
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.54
    Marker Score: 407
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.54
    Marker Score: 1,132
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.54
    Marker Score: 2,120
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.53
    Marker Score: 2,066
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.53
    Marker Score: 1,431
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.52
    Marker Score: 555
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.51
    Marker Score: 861
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.5
    Marker Score: 9,993
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 330
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.5
    Marker Score: 360
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.5
    Marker Score: 18,290
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.49
    Marker Score: 234
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.49
    Marker Score: 702
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.49
    Marker Score: 612
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.48
    Marker Score: 163
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.48
    Marker Score: 169
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 123
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 969
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 288
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.44
    Marker Score: 141
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.43
    Marker Score: 409
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.43
    Marker Score: 312
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.42
    Marker Score: 194
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 221
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.42
    Marker Score: 444
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 397
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.41
    Marker Score: 328
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.41
    Marker Score: 247
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.41
    Marker Score: 430
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4
    Marker Score: 2,425
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.4
    Marker Score: 140
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4
    Marker Score: 13,765
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.39
    Marker Score: 193
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.39
    Marker Score: 246
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.39
    Marker Score: 205
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.38
    Marker Score: 413
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.38
    Marker Score: 14,379
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.38
    Marker Score: 93
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.37
    Marker Score: 87
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.37
    Marker Score: 175
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.36
    Marker Score: 147
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.36
    Marker Score: 1,349
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.36
    Marker Score: 203
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.36
    Marker Score: 737
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.36
    Marker Score: 92
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 167
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.35
    Marker Score: 173
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.35
    Marker Score: 549
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.34
    Marker Score: 385
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.34
    Marker Score: 1,395
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.34
    Marker Score: 924
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.34
    Marker Score: 76
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.33
    Marker Score: 3,350
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.33
    Marker Score: 3,844
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.33
    Marker Score: 776

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule Regulator:** KATNB1 is a regulatory subunit of the katanin complex, which is responsible for microtubule severing and depolymerization. 2. **Cellular Expression:** KATNB1 is significantly expressed in various cell types, including cardiac muscle myoblasts, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. 3. **Diverse Functions:** KATNB1 is involved in various cellular processes, including positive regulation of microtubule depolymerization, negative regulation of microtubule depolymerization, and regulation of apoptotic processes. **Pathways and Functions:** 1. **Microtubule Dynamics:** KATNB1 regulates microtubule severing and depolymerization through its interaction with microtubules and the katanin complex. 2. **Cell Division:** KATNB1 plays a crucial role in microtubule organization and separation during mitosis, ensuring accurate chromosome segregation. 3. **Growth Cone Formation:** KATNB1 is involved in the regulation of microtubule dynamics during growth cone formation, a process essential for axon guidance and neuronal development. 4. **Apoptosis:** KATNB1 regulates microtubule depolymerization, which is a key event in apoptosis (programmed cell death). 5. **Neuronal Development:** KATNB1 is essential for the development of neuronal projections and the regulation of microtubule dynamics during neuronal migration. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in KATNB1 have been linked to neurological disorders, such as autism spectrum disorder and schizophrenia, highlighting its importance in neuronal development and function. 2. **Cancer:** Aberrant microtubule dynamics is a hallmark of cancer, and KATNB1 dysregulation may contribute to cancer progression and metastasis. 3. **Neurodegenerative Diseases:** KATNB1 may play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where microtubule dysfunction is a key feature. In conclusion, KATNB1 is a critical gene involved in microtubule dynamics and cellular processes. Its dysregulation may contribute to various human diseases, highlighting the importance of understanding its function and regulation. Further research is needed to elucidate the mechanisms of KATNB1 and its role in human disease.

Genular Protein ID: 3689110329

Symbol: KTNB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BVA0 A6NCG6 O60620

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9568719

Title: Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.

PubMed ID: 9568719

DOI: 10.1016/s0092-8674(00)81578-0

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9658175

Title: Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.

PubMed ID: 9658175

DOI: 10.1091/mbc.9.7.1847

PubMed ID: 10751153

Title: Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.

PubMed ID: 10751153

DOI: 10.1242/jcs.113.9.1623

PubMed ID: 16203747

Title: Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.

PubMed ID: 16203747

DOI: 10.1093/hmg/ddi339

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24486153

Title: Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

PubMed ID: 24486153

DOI: 10.1016/j.devcel.2014.01.001

PubMed ID: 25521378

Title: Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors.

PubMed ID: 25521378

DOI: 10.1016/j.neuron.2014.12.014

PubMed ID: 26929214

Title: Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing.

PubMed ID: 26929214

DOI: 10.1074/mcp.m115.056465

PubMed ID: 25521379

Title: Katanin p80 regulates human cortical development by limiting centriole and cilia number.

PubMed ID: 25521379

DOI: 10.1016/j.neuron.2014.12.017

Sequence Information:

  • Length: 655
  • Mass: 72334
  • Checksum: 411903E306B6EC16
  • Sequence:
    • MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 
ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV RCLRFSPDGK WLASAADDHT VKLWDLTAGK 
MMSEFPGHTG PVNVVEFHPN EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN 
PDGCCLYSGC QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV 
DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV KQNSESERRS 
PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS EPFPAPPEDD AATAKEAAKP 
SPAMDVQFPV PNLEVLPRPP VVASTPAPKA EPAIIPATRN EPIGLKASDF LPAVKIPQQA 
ELVDEDAMSQ IRKGHDTMCV VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL 
LNIVNQKASL WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP 
PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL MASLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.