Details for: CDKN2C

Gene ID: 1031

Symbol: CDKN2C

Ensembl ID: ENSG00000123080

Description: cyclin dependent kinase inhibitor 2C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.3069
    Cell Significance Index: -12.7600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.9422
    Cell Significance Index: -6.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.2448
    Cell Significance Index: -13.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.8857
    Cell Significance Index: -10.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.9211
    Cell Significance Index: -13.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4245
    Cell Significance Index: -11.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8412
    Cell Significance Index: -10.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5909
    Cell Significance Index: -14.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4353
    Cell Significance Index: -7.4800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.8877
    Cell Significance Index: 11.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.7369
    Cell Significance Index: 14.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0836
    Cell Significance Index: 117.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9173
    Cell Significance Index: 149.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5468
    Cell Significance Index: 75.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5056
    Cell Significance Index: 59.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4485
    Cell Significance Index: 31.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3072
    Cell Significance Index: 8.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2656
    Cell Significance Index: 4.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2248
    Cell Significance Index: 22.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1378
    Cell Significance Index: 60.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1350
    Cell Significance Index: 23.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1315
    Cell Significance Index: 3.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1076
    Cell Significance Index: 21.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0993
    Cell Significance Index: 3.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0944
    Cell Significance Index: 6.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0540
    Cell Significance Index: 1.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0474
    Cell Significance Index: 2.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0428
    Cell Significance Index: 1.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0419
    Cell Significance Index: 1.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0317
    Cell Significance Index: 2.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0248
    Cell Significance Index: 4.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0179
    Cell Significance Index: 2.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0128
    Cell Significance Index: 6.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0020
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0039
    Cell Significance Index: -2.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0064
    Cell Significance Index: -11.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0074
    Cell Significance Index: -2.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0146
    Cell Significance Index: -11.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0148
    Cell Significance Index: -1.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0167
    Cell Significance Index: -10.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0215
    Cell Significance Index: -7.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0250
    Cell Significance Index: -11.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0317
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0346
    Cell Significance Index: -7.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0384
    Cell Significance Index: -1.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0386
    Cell Significance Index: -4.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0463
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0466
    Cell Significance Index: -5.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0480
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0490
    Cell Significance Index: -5.5900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0582
    Cell Significance Index: -0.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0732
    Cell Significance Index: -9.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0780
    Cell Significance Index: -2.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0780
    Cell Significance Index: -2.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0793
    Cell Significance Index: -11.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0797
    Cell Significance Index: -1.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1001
    Cell Significance Index: -4.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1148
    Cell Significance Index: -9.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1155
    Cell Significance Index: -2.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1312
    Cell Significance Index: -2.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1334
    Cell Significance Index: -6.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1340
    Cell Significance Index: -13.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1496
    Cell Significance Index: -11.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1582
    Cell Significance Index: -8.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1648
    Cell Significance Index: -1.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1704
    Cell Significance Index: -12.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1721
    Cell Significance Index: -10.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1868
    Cell Significance Index: -5.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1904
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1941
    Cell Significance Index: -13.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2242
    Cell Significance Index: -5.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2269
    Cell Significance Index: -13.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2281
    Cell Significance Index: -11.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2338
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2481
    Cell Significance Index: -2.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2661
    Cell Significance Index: -6.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2669
    Cell Significance Index: -5.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2748
    Cell Significance Index: -5.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2775
    Cell Significance Index: -3.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2922
    Cell Significance Index: -4.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2980
    Cell Significance Index: -10.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2995
    Cell Significance Index: -6.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3102
    Cell Significance Index: -10.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3117
    Cell Significance Index: -4.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3405
    Cell Significance Index: -2.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3484
    Cell Significance Index: -15.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3553
    Cell Significance Index: -9.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3565
    Cell Significance Index: -8.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3584
    Cell Significance Index: -9.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3662
    Cell Significance Index: -8.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3705
    Cell Significance Index: -12.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3816
    Cell Significance Index: -6.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell cycle regulation**: CDKN2C is a potent inhibitor of cyclin-dependent kinases (CDKs), which are essential for cell cycle progression. By binding to CDKs, CDKN2C prevents the phosphorylation of key substrates, thereby inhibiting the G1/S transition and cell cycle progression. 2. **Negative regulation of cell growth and proliferation**: CDKN2C's ability to inhibit cell cycle progression and CDK activity makes it a critical negative regulator of cell growth and proliferation. 3. **Stem cell regulation**: CDKN2C is expressed in stem cells and plays a crucial role in regulating their proliferation and self-renewal. 4. **Cellular responses to stress**: CDKN2C is involved in regulating cellular responses to oxidative stress and oncogene-induced senescence, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Cell cycle regulation**: CDKN2C's interaction with CDKs and its role in inhibiting the G1/S transition are critical for regulating the cell cycle. 2. **Negative regulation of cell growth and proliferation**: CDKN2C's ability to inhibit CDK activity and cell cycle progression makes it a key negative regulator of cell growth and proliferation. 3. **Stem cell regulation**: CDKN2C's expression in stem cells and its role in regulating their proliferation and self-renewal are critical for maintaining stem cell homeostasis. 4. **Cellular responses to stress**: CDKN2C's involvement in regulating cellular responses to oxidative stress and oncogene-induced senescence highlights its role in maintaining cellular homeostasis. **Clinical Significance:** 1. **Cancer**: CDKN2C's role in regulating cell growth and proliferation makes it a potential tumor suppressor gene. Alterations in CDKN2C expression have been linked to various cancers, including breast, colon, and prostate cancer. 2. **Neurological disorders**: CDKN2C's expression in neural cells and its role in regulating cellular responses to stress make it a potential therapeutic target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune system**: CDKN2C's expression in immune cells and its role in regulating cellular responses to stress make it a potential therapeutic target for autoimmune diseases. 4. **Stem cell transplantation**: CDKN2C's role in regulating stem cell proliferation and self-renewal makes it a potential therapeutic target for stem cell transplantation. In conclusion, CDKN2C is a critical regulator of the cell cycle and cellular responses to stress. Its role in regulating cell growth and proliferation, stem cell regulation, and cellular responses to stress highlights its importance in maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms underlying CDKN2C's functions and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 4288229266

Symbol: CDN2C_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor C

UniProtKB Accession Codes:

P42773 Q8TB83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8001816

Title: Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

PubMed ID: 8001816

DOI: 10.1101/gad.8.24.2939

PubMed ID: 9636670

Title: Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer.

PubMed ID: 9636670

DOI: 10.1006/bbrc.1998.8497

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 9437433

Title: Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations.

PubMed ID: 9437433

DOI: 10.1038/nsb0198-74

PubMed ID: 10074345

Title: Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A.

PubMed ID: 10074345

DOI: 10.1021/bi982286e

PubMed ID: 8840966

Title: A p18 mutant defective in CDK6 binding in human breast cancer cells.

PubMed ID: 8840966

Sequence Information:

  • Length: 168
  • Mass: 18127
  • Checksum: 5D66AFA715186E9A
  • Sequence:
    • MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG 
ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLRVVE 
FLVKHTASNV GHRNHKGDTA CDLARLYGRN EVVSLMQANG AGGATNLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.