CDKN2C | ENSG00000123080 | NCBI 1031

Details for: CDKN2C

Gene ID: 1031

Symbol: CDKN2C

Ensembl ID: ENSG00000123080

Description: cyclin dependent kinase inhibitor 2C

Associated with

Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
G1 phase
(R-HSA-69236)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Cell cycle
(GO:0007049)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of stem cell proliferation
(GO:2000647)
Nucleus
(GO:0005634)
Oligodendrocyte differentiation
(GO:0048709)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Stem cell proliferation
(GO:0072089)

Other Information

Proteins

Cyclin-dependent kinase 4 inhibitor C

Genular Protein ID: 4288229266

Symbol: CDN2C_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor C

UniProtKB Accession Codes:

P42773 Q8TB83

Database IDs:

Citations:

PubMed ID: 8001816

Title: Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

PubMed ID: 8001816

DOI: 10.1101/gad.8.24.2939

PubMed ID: 9636670

Title: Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer.

PubMed ID: 9636670

DOI: 10.1006/bbrc.1998.8497

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 9437433

Title: Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations.

PubMed ID: 9437433

DOI: 10.1038/nsb0198-74

PubMed ID: 10074345

Title: Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A.

PubMed ID: 10074345

DOI: 10.1021/bi982286e

PubMed ID: 8840966

Title: A p18 mutant defective in CDK6 binding in human breast cancer cells.

PubMed ID: 8840966

Sequence Information:

Length: 168
Mass: 18127
Checksum: 5D66AFA715186E9A
Sequence:

MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG 
ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLRVVE 
FLVKHTASNV GHRNHKGDTA CDLARLYGRN EVVSLMQANG AGGATNLQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN2C

Associated with

Other Information

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. PubMed ID: 8001816

Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. PubMed ID: 9636670

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations. PubMed ID: 9437433

Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. PubMed ID: 10074345

A p18 mutant defective in CDK6 binding in human breast cancer cells. PubMed ID: 8840966