Details for: CDKN2D

Gene ID: 1032

Symbol: CDKN2D

Ensembl ID: ENSG00000129355

Description: cyclin dependent kinase inhibitor 2D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.7503
    Cell Significance Index: -21.7500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.5875
    Cell Significance Index: -12.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.8883
    Cell Significance Index: -21.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.6662
    Cell Significance Index: -23.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.5506
    Cell Significance Index: -21.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.4020
    Cell Significance Index: -18.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1855
    Cell Significance Index: -16.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8286
    Cell Significance Index: -23.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6948
    Cell Significance Index: -14.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7557
    Cell Significance Index: 242.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4146
    Cell Significance Index: 23.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2443
    Cell Significance Index: 145.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0813
    Cell Significance Index: 56.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0034
    Cell Significance Index: 18.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8626
    Cell Significance Index: 18.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8501
    Cell Significance Index: 52.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6937
    Cell Significance Index: 112.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6434
    Cell Significance Index: 69.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5978
    Cell Significance Index: 119.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4851
    Cell Significance Index: 57.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3884
    Cell Significance Index: 212.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3575
    Cell Significance Index: 18.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3503
    Cell Significance Index: 22.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3323
    Cell Significance Index: 7.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3269
    Cell Significance Index: 2.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3231
    Cell Significance Index: 9.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2996
    Cell Significance Index: 20.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2922
    Cell Significance Index: 35.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2214
    Cell Significance Index: 13.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2014
    Cell Significance Index: 72.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2009
    Cell Significance Index: 5.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1900
    Cell Significance Index: 84.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1204
    Cell Significance Index: 11.9100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1192
    Cell Significance Index: 0.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1159
    Cell Significance Index: 20.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0748
    Cell Significance Index: 2.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0693
    Cell Significance Index: 9.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0413
    Cell Significance Index: 2.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0376
    Cell Significance Index: 4.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0198
    Cell Significance Index: 0.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0124
    Cell Significance Index: 0.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0109
    Cell Significance Index: 0.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0070
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0105
    Cell Significance Index: -19.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0109
    Cell Significance Index: -2.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0132
    Cell Significance Index: -24.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0137
    Cell Significance Index: -9.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0139
    Cell Significance Index: -0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0141
    Cell Significance Index: -0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0160
    Cell Significance Index: -21.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0238
    Cell Significance Index: -17.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0240
    Cell Significance Index: -4.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0252
    Cell Significance Index: -19.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0332
    Cell Significance Index: -21.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0396
    Cell Significance Index: -1.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0465
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0473
    Cell Significance Index: -21.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0505
    Cell Significance Index: -10.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0506
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0523
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0532
    Cell Significance Index: -11.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0600
    Cell Significance Index: -17.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0916
    Cell Significance Index: -11.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0931
    Cell Significance Index: -9.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1005
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1015
    Cell Significance Index: -11.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1274
    Cell Significance Index: -1.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1280
    Cell Significance Index: -9.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1397
    Cell Significance Index: -3.9100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1427
    Cell Significance Index: -1.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1496
    Cell Significance Index: -21.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1538
    Cell Significance Index: -4.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1704
    Cell Significance Index: -12.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2033
    Cell Significance Index: -9.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2147
    Cell Significance Index: -12.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2153
    Cell Significance Index: -22.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2340
    Cell Significance Index: -10.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2539
    Cell Significance Index: -4.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2560
    Cell Significance Index: -6.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2760
    Cell Significance Index: -21.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2808
    Cell Significance Index: -3.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2816
    Cell Significance Index: -21.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2895
    Cell Significance Index: -17.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2972
    Cell Significance Index: -6.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3088
    Cell Significance Index: -10.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3266
    Cell Significance Index: -9.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3284
    Cell Significance Index: -12.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3665
    Cell Significance Index: -9.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3713
    Cell Significance Index: -8.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3754
    Cell Significance Index: -12.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3848
    Cell Significance Index: -10.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3919
    Cell Significance Index: -6.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3953
    Cell Significance Index: -12.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4118
    Cell Significance Index: -8.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4254
    Cell Significance Index: -2.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Cycle Regulation:** CDKN2D is a key inhibitor of cyclin-dependent kinases (CDKs), specifically CDK4 and CDK6, which are essential for cell cycle progression. By binding to these CDKs, CDKN2D prevents the phosphorylation and activation of downstream targets, thereby inhibiting cell cycle progression. 2. **Apoptosis and Senescence:** CDKN2D also regulates apoptosis and senescence, two critical mechanisms that prevent cancer and maintain tissue homeostasis. By inhibiting CDKs, CDKN2D reduces the activity of pro-apoptotic and pro-senescence pathways, thereby promoting cell survival. 3. **Diverse Expression Patterns:** CDKN2D is expressed in a wide range of cell types, including germ cells, immune cells, and neurons, underscoring its importance in maintaining tissue homeostasis and preventing disease. 4. **Interactions with Other Proteins:** CDKN2D interacts with various proteins, including CDKs, protein kinases, and transcription factors, to regulate its activity and downstream effects. **Pathways and Functions:** 1. **Autophagic Cell Death:** CDKN2D regulates autophagic cell death, a process by which cells undergo programmed cell death in response to stress or damage. 2. **Cell Cycle Regulation:** CDKN2D inhibits cell cycle progression by binding to CDK4 and CDK6, preventing their activation and subsequent phosphorylation of downstream targets. 3. **Apoptosis and Senescence:** CDKN2D regulates apoptosis and senescence by inhibiting pro-apoptotic and pro-senescence pathways, promoting cell survival. 4. **Cyclin-Dependent Kinase Activity:** CDKN2D regulates cyclin-dependent kinase activity by binding to CDKs, preventing their activation and subsequent phosphorylation of downstream targets. 5. **Cellular Responses to Stimuli:** CDKN2D regulates cellular responses to stimuli, including oxidative stress, UV radiation, and retinoic acid. **Clinical Significance:** 1. **Cancer:** CDKN2D is a tumor suppressor gene that is frequently lost or mutated in various cancers, including melanoma, pancreatic cancer, and prostate cancer. 2. **Neurological Disorders:** CDKN2D is implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Immune System:** CDKN2D plays a critical role in regulating immune responses, including the activation and proliferation of immune cells. 4. **Aging and Senescence:** CDKN2D is involved in regulating cellular senescence, a process by which cells undergo permanent cell cycle arrest in response to stress or damage. In conclusion, CDKN2D is a multifunctional gene that plays a critical role in regulating various cellular processes, including cell cycle progression, apoptosis, and senescence. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immune system dysfunction. Further research is needed to fully elucidate the mechanisms and implications of CDKN2D in human health and disease.

Genular Protein ID: 1768995202

Symbol: CDN2D_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor D

UniProtKB Accession Codes:

P55273 Q13102 Q6FGE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8575754

Title: Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.

PubMed ID: 8575754

DOI: 10.1006/geno.1995.9957

PubMed ID: 7739548

Title: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.

PubMed ID: 7739548

DOI: 10.1128/mcb.15.5.2682

PubMed ID: 8741839

Title: Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.

PubMed ID: 8741839

DOI: 10.1091/mbc.7.1.57

PubMed ID: 10390011

Title: Mutation testing in melanoma families: INK4A, CDK4 and INK4D.

PubMed ID: 10390011

DOI: 10.1038/sj.bjc.6690354

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 9751050

Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

PubMed ID: 9751050

DOI: 10.1038/26155

PubMed ID: 9782052

Title: Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a).

PubMed ID: 9782052

DOI: 10.1016/s0969-2126(98)00128-2

Sequence Information:

  • Length: 166
  • Mass: 17700
  • Checksum: 2FACD11CF56340DC
  • Sequence:
    • MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSTAIALEL 
LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV NVPDGTGALP IHLAVQEGHT 
AVVSFLAAES DLHRRDARGL TPLELALQRG AQDLVDILQG HMVAPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.