CDKN2D | ENSG00000129355 | NCBI 1032

Details for: CDKN2D

Gene ID: 1032

Symbol: CDKN2D

Ensembl ID: ENSG00000129355

Description: cyclin dependent kinase inhibitor 2D

Associated with

Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
G1 phase
(R-HSA-69236)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Autophagic cell death
(GO:0048102)
Cell cycle
(GO:0007049)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cyclin d2-cdk4 complex
(GO:0097129)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna synthesis involved in dna repair
(GO:0000731)
Negative regulation of cell cycle g1/s phase transition
(GO:1902807)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of phosphorylation
(GO:0042326)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Response to retinoic acid
(GO:0032526)
Response to uv
(GO:0009411)
Response to vitamin d
(GO:0033280)
Sensory perception of sound
(GO:0007605)

Other Information

Proteins

Cyclin-dependent kinase 4 inhibitor D

Genular Protein ID: 1768995202

Symbol: CDN2D_HUMAN

Name: Cyclin-dependent kinase 4 inhibitor D

UniProtKB Accession Codes:

P55273 Q13102 Q6FGE9

Database IDs:

Citations:

PubMed ID: 8575754

Title: Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.

PubMed ID: 8575754

DOI: 10.1006/geno.1995.9957

PubMed ID: 7739548

Title: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.

PubMed ID: 7739548

DOI: 10.1128/mcb.15.5.2682

PubMed ID: 8741839

Title: Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.

PubMed ID: 8741839

DOI: 10.1091/mbc.7.1.57

PubMed ID: 10390011

Title: Mutation testing in melanoma families: INK4A, CDK4 and INK4D.

PubMed ID: 10390011

DOI: 10.1038/sj.bjc.6690354

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9482106

Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.

PubMed ID: 9482106

DOI: 10.1038/sj.onc.1201570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 9751050

Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

PubMed ID: 9751050

DOI: 10.1038/26155

PubMed ID: 9782052

Title: Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a).

PubMed ID: 9782052

DOI: 10.1016/s0969-2126(98)00128-2

Sequence Information:

Length: 166
Mass: 17700
Checksum: 2FACD11CF56340DC
Sequence:

MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSTAIALEL 
LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV NVPDGTGALP IHLAVQEGHT 
AVVSFLAAES DLHRRDARGL TPLELALQRG AQDLVDILQG HMVAPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN2D

Associated with

Other Information

Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. PubMed ID: 8575754

Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. PubMed ID: 7739548

Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. PubMed ID: 8741839

Mutation testing in melanoma families: INK4A, CDK4 and INK4D. PubMed ID: 10390011

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. PubMed ID: 9482106

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. PubMed ID: 9751050

Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a). PubMed ID: 9782052