Details for: CDKN2D
Gene ID: 1032
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CDKN2D
Ensembl ID: ENSG00000129355
Description: cyclin dependent kinase inhibitor 2D
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 33.23rCSI 45.28%PRS 51.54
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CSI 22.53rCSI 32.49%PRS 69.06
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CSI 18.71rCSI 13.06%PRS 62.29
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CSI 18.63rCSI 53.18%PRS 71.47
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CSI 18.29rCSI 22.95%PRS 69.91
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CSI 16.53rCSI 12.74%PRS 59.92
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CSI 15.38rCSI 49.88%PRS 60.26
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CSI 15.26rCSI 66.19%PRS 72.29
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CSI 12.51rCSI 10.36%PRS 61.5
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CSI 10.93rCSI 6.45%PRS 76.91
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CSI 10.45rCSI 9.52%PRS 74.44
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CSI 10.41rCSI 9.12%PRS 69.58
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CSI 10.3rCSI 42.75%PRS 63.74
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CSI 9.63rCSI 12.62%PRS 73.17
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CSI 9.58rCSI 32.39%PRS 63.97
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CSI 8.64rCSI 19.08%PRS 46.03
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CSI 7.98rCSI 7.96%PRS 52.85
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CSI 7.96rCSI 9.12%PRS 78.45
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CSI 7.85rCSI 5.87%PRS 74.75
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CSI 7.69rCSI 10.28%PRS 80.66
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CSI 7.56rCSI 11.53%PRS 55.95
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CSI 7.44rCSI 5.58%PRS 86
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CSI 7.19rCSI 40.25%PRS 66.89
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CSI 6.32rCSI 5.47%PRS 64.4
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CSI 5.89rCSI 4.92%PRS 71.11
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CSI 5.47rCSI 3.65%PRS 79.78
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CSI 5.41rCSI 10.87%PRS 48.81
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CSI 5.39rCSI 3.74%PRS 70.53
-
CSI 5.24rCSI 7.13%PRS 71.43
-
CSI 5.06rCSI 7.77%PRS 56.14
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CSI 4.82rCSI 24.21%PRS 72.05
-
CSI 4.76rCSI 7.63%PRS 81.07
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CSI 4.62rCSI 16.61%PRS 40.05
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CSI 4.57rCSI 7.83%PRS 68.41
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CSI 4.55rCSI 4.61%PRS 86
-
CSI 4.54rCSI 6.93%PRS 68.99
-
CSI 4.53rCSI 3.63%PRS 80.09
-
CSI 4.52rCSI 5.78%PRS 81.56
-
CSI 4.5rCSI 14.73%PRS 85.68
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CSI 4.42rCSI 13.83%PRS 45.81
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CSI 4.35rCSI 12.6%PRS 61.06
-
CSI 4.22rCSI 5.41%PRS 56.94
-
CSI 4.18rCSI 32.78%PRS 71.59
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CSI 4.16rCSI 4.81%PRS 52.91
-
CSI 4.11rCSI 3.11%PRS 73.51
-
CSI 3.99rCSI 7.62%PRS 74.91
-
CSI 3.86rCSI 2.77%PRS 73.98
-
CSI 3.81rCSI 2.83%PRS 72.84
-
CSI 3.77rCSI 3.63%PRS 81.26
-
CSI 3.71rCSI 2.82%PRS 72.52
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CSI 3.71rCSI 4.97%PRS 59.97
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CSI 3.69rCSI 5.76%PRS 83.72
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CSI 3.67rCSI 4.57%PRS 70.47
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CSI 3.67rCSI 8.32%PRS 63.73
-
CSI 3.64rCSI 8.4%PRS 49.02
-
CSI 3.38rCSI 21.76%PRS 77.47
-
CSI 3.37rCSI 9.66%PRS 79.26
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CSI 3.23rCSI 2.72%PRS 76.67
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CSI 3.23rCSI 3.98%PRS 74.31
-
CSI 3.14rCSI 4.62%PRS 53.59
-
CSI 3.11rCSI 5.62%PRS 74.42
-
CSI 2.79rCSI 4.93%PRS 40.66
-
CSI 2.79rCSI 2.08%PRS 76.47
-
CSI 2.79rCSI 17.15%PRS 74.94
-
CSI 2.73rCSI 8.06%PRS 62.79
-
CSI 2.66rCSI 2.11%PRS 81.31
-
CSI 2.54rCSI 2.24%PRS 47.47
-
CSI 2.51rCSI 9.49%PRS 42.49
-
CSI 2.48rCSI 15.03%PRS 78.73
-
CSI 2.37rCSI 2.94%PRS 39.7
-
CSI 2.36rCSI 2.18%PRS 61.04
-
CSI 2.34rCSI 2.15%PRS 68.38
-
CSI 2.33rCSI 3.98%PRS 77.84
-
CSI 2.3rCSI 7.18%PRS 43.21
-
CSI 2.3rCSI 3.41%PRS 61.39
-
CSI 2.24rCSI 2.4%PRS 58.82
-
CSI 2.18rCSI 3%PRS 79.37
-
CSI 2.17rCSI 2.95%PRS 84.19
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CSI 2.15rCSI 4.41%PRS 50.42
-
CSI 2.14rCSI 1.84%PRS 65.33
-
CSI 2.12rCSI 2.89%PRS 65.49
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CSI 2.06rCSI 1.66%PRS 60.87
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CSI 2.01rCSI 4.88%PRS 40.29
-
CSI 2.01rCSI 1.51%PRS 64.94
-
CSI 2.01rCSI 13.2%PRS 85.36
-
CSI 2rCSI 3.02%PRS 63.58
-
CSI 1.99rCSI 4.13%PRS 56.83
-
CSI 1.96rCSI 1.77%PRS 56.4
-
CSI 1.95rCSI 1.99%PRS 72.89
-
CSI 1.95rCSI 2.33%PRS 41.45
-
CSI 1.88rCSI 11.06%PRS 42.97
-
CSI 1.86rCSI 2.69%PRS 75.78
-
CSI 1.84rCSI 1.6%PRS 70.28
-
CSI 1.81rCSI 3.74%PRS 61.78
-
CSI 1.74rCSI 4.62%PRS 71.25
-
CSI 1.72rCSI 1.99%PRS 49.63
-
CSI 1.7rCSI 2.19%PRS 42.86
-
CSI 1.69rCSI 6.88%PRS 54.43
-
CSI 1.54rCSI 3.28%PRS 59.31
-
CSI 1.52rCSI 3.35%PRS 63.79
-
CSI 0.3rCSI 6.2%PRS 75.8%
-
CSI 0.5rCSI 8.2%PRS 88.2%
-
CSI 0.7rCSI 1.1%PRS 41.6%
-
CSI 0.7rCSI 3.4%PRS 86.8%
-
CSI 0.8rCSI 4.2%PRS 72.3%
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CSI 0.9rCSI 1.4%PRS 49.3%
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CSI 0.9rCSI 2.6%PRS 77.5%
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CSI 0.9rCSI 4.9%PRS 83.4%
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CSI 0.9rCSI 1.1%PRS 79.2%
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CSI 0.9rCSI 8.7%PRS 70.5%
-
CSI 1.0rCSI 2.3%PRS 57.6%
-
CSI 1.1rCSI 3.9%PRS 79.3%
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CSI 1.2rCSI 1.9%PRS 43.8%
-
CSI 1.3rCSI 1.9%PRS 55.8%
-
CSI 1.4rCSI 3.0%PRS 78.0%
-
CSI 1.5rCSI 6.6%PRS 50.3%
-
CSI 1.5rCSI 2.3%PRS 68.5%
-
CSI 1.5rCSI 3.4%PRS 63.8%
-
CSI 1.5rCSI 3.3%PRS 59.3%
-
CSI 1.7rCSI 6.9%PRS 54.4%
-
CSI 1.7rCSI 2.2%PRS 42.9%
-
CSI 1.7rCSI 2.0%PRS 49.6%
-
CSI 1.7rCSI 4.6%PRS 71.3%
-
CSI 1.8rCSI 3.7%PRS 61.8%
-
CSI 1.8rCSI 1.6%PRS 70.3%
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CSI 1.9rCSI 2.7%PRS 75.8%
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CSI 1.9rCSI 11.1%PRS 43.0%
-
CSI 2.0rCSI 2.3%PRS 41.5%
-
CSI 2.0rCSI 2.0%PRS 72.9%
-
CSI 2.0rCSI 1.8%PRS 56.4%
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CSI 2.0rCSI 4.1%PRS 56.8%
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CSI 2.0rCSI 3.0%PRS 63.6%
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CSI 2.0rCSI 13.2%PRS 85.4%
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CSI 2.0rCSI 1.5%PRS 64.9%
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CSI 2.0rCSI 4.9%PRS 40.3%
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CSI 2.1rCSI 1.7%PRS 60.9%
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CSI 2.1rCSI 2.9%PRS 65.5%
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CSI 2.1rCSI 1.8%PRS 65.3%
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CSI 2.2rCSI 4.4%PRS 50.4%
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CSI 2.2rCSI 3.0%PRS 84.2%
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CSI 2.2rCSI 3.0%PRS 79.4%
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CSI 2.2rCSI 2.4%PRS 58.8%
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CSI 2.3rCSI 3.4%PRS 61.4%
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CSI 2.3rCSI 7.2%PRS 43.2%
-
CSI 2.3rCSI 4.0%PRS 77.8%
-
CSI 2.3rCSI 2.2%PRS 68.4%
-
CSI 2.4rCSI 2.2%PRS 61.0%
-
CSI 2.4rCSI 2.9%PRS 39.7%
-
CSI 2.5rCSI 15.0%PRS 78.7%
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CSI 2.5rCSI 9.5%PRS 42.5%
-
CSI 2.5rCSI 2.2%PRS 47.5%
-
CSI 2.7rCSI 2.1%PRS 81.3%
-
CSI 2.7rCSI 8.1%PRS 62.8%
-
CSI 2.8rCSI 17.2%PRS 74.9%
-
CSI 2.8rCSI 2.1%PRS 76.5%
-
CSI 2.8rCSI 4.9%PRS 40.7%
-
CSI 3.1rCSI 5.6%PRS 74.4%
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CSI 3.1rCSI 4.6%PRS 53.6%
-
CSI 3.2rCSI 4.0%PRS 74.3%
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CSI 3.2rCSI 2.7%PRS 76.7%
-
CSI 3.4rCSI 9.7%PRS 79.3%
-
CSI 3.4rCSI 21.8%PRS 77.5%
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CSI 3.6rCSI 8.4%PRS 49.0%
-
CSI 3.7rCSI 8.3%PRS 63.7%
-
CSI 3.7rCSI 4.6%PRS 70.5%
-
CSI 3.7rCSI 5.8%PRS 83.7%
-
CSI 3.7rCSI 5.0%PRS 60.0%
-
CSI 3.7rCSI 2.8%PRS 72.5%
-
CSI 3.8rCSI 3.6%PRS 81.3%
-
CSI 3.8rCSI 2.8%PRS 72.8%
-
CSI 3.9rCSI 2.8%PRS 74.0%
-
CSI 4.0rCSI 7.6%PRS 74.9%
-
CSI 4.1rCSI 3.1%PRS 73.5%
-
CSI 4.2rCSI 4.8%PRS 52.9%
-
CSI 4.2rCSI 32.8%PRS 71.6%
-
CSI 4.2rCSI 5.4%PRS 56.9%
-
CSI 4.4rCSI 12.6%PRS 61.1%
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CSI 4.4rCSI 13.8%PRS 45.8%
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CSI 4.5rCSI 14.7%PRS 85.7%
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CSI 4.5rCSI 5.8%PRS 81.6%
-
CSI 4.5rCSI 3.6%PRS 80.1%
-
CSI 4.5rCSI 6.9%PRS 69.0%
-
CSI 4.6rCSI 4.6%PRS 86.0%
-
CSI 4.6rCSI 7.8%PRS 68.4%
-
CSI 4.6rCSI 16.6%PRS 40.1%
-
CSI 4.8rCSI 7.6%PRS 81.1%
-
CSI 4.8rCSI 24.2%PRS 72.1%
-
CSI 5.1rCSI 7.8%PRS 56.1%
-
CSI 5.2rCSI 7.1%PRS 71.4%
-
CSI 5.4rCSI 3.7%PRS 70.5%
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CSI 5.4rCSI 10.9%PRS 48.8%
-
CSI 5.5rCSI 3.7%PRS 79.8%
-
CSI 5.9rCSI 4.9%PRS 71.1%
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CSI 6.3rCSI 5.5%PRS 64.4%
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CSI 7.2rCSI 40.3%PRS 66.9%
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CSI 7.4rCSI 5.6%PRS 86.0%
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CSI 7.6rCSI 11.5%PRS 56.0%
-
CSI 7.7rCSI 10.3%PRS 80.7%
-
CSI 7.9rCSI 5.9%PRS 74.8%
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CSI 8.0rCSI 9.1%PRS 78.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1768995202
Symbol: CDN2D_HUMAN
Name: Cyclin-dependent kinase 4 inhibitor D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8575754
Title: Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.
PubMed ID: 8575754
PubMed ID: 7739548
Title: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
PubMed ID: 7739548
PubMed ID: 8741839
Title: Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.
PubMed ID: 8741839
DOI: 10.1091/mbc.7.1.57
PubMed ID: 10390011
Title: Mutation testing in melanoma families: INK4A, CDK4 and INK4D.
PubMed ID: 10390011
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 9482106
Title: Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells.
PubMed ID: 9482106
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 9751050
Title: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
PubMed ID: 9751050
DOI: 10.1038/26155
PubMed ID: 9782052
Title: Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a).
PubMed ID: 9782052
Sequence Information:
- Length: 166
- Mass: 17700
- Checksum: 2FACD11CF56340DC
- Sequence:
MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG AQDLVDILQG HMVAPL