RRAGB | ENSG00000083750 | NCBI 10325

Details for: RRAGB

Gene ID: 10325

Symbol: RRAGB

Ensembl ID: ENSG00000083750

Description: Ras related GTP binding B

Associated with

Amino acids regulate mtorc1
(R-HSA-9639288)
Autophagy
(R-HSA-9612973)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Energy dependent regulation of mtor by lkb1-ampk
(R-HSA-380972)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Macroautophagy
(R-HSA-1632852)
Mtorc1-mediated signalling
(R-HSA-166208)
Mtor signalling
(R-HSA-165159)
Pip3 activates akt signaling
(R-HSA-1257604)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Signal transduction
(R-HSA-162582)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to leucine starvation
(GO:1990253)
Cellular response to starvation
(GO:0009267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gtpase activity
(GO:0003924)
Gtpase binding
(GO:0051020)
Gtp binding
(GO:0005525)
Gtr1-gtr2 gtpase complex
(GO:1990131)
Guanyl ribonucleotide binding
(GO:0032561)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Negative regulation of autophagy
(GO:0010507)
Nucleus
(GO:0005634)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of tor signaling
(GO:0032008)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of tor signaling
(GO:0032006)

Other Information

Proteins

RRAGB_HUMAN

Genular Protein ID: 3991444378

Symbol: RRAGB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VZM2 A8K042 Q15348 Q8N3T0

Database IDs:

Citations:

PubMed ID: 7499430

Title: Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases.

PubMed ID: 7499430

DOI: 10.1074/jbc.270.48.28982

PubMed ID: 9394008

Title: RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.

PubMed ID: 9394008

DOI: 10.1242/jcs.111.1.11

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11073942

Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.

PubMed ID: 11073942

DOI: 10.1074/jbc.m004389200

PubMed ID: 18497260

Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

PubMed ID: 18497260

DOI: 10.1126/science.1157535

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 22575674

Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.

PubMed ID: 22575674

DOI: 10.1016/j.molcel.2012.04.007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24095279

Title: The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

PubMed ID: 24095279

DOI: 10.1016/j.molcel.2013.09.016

PubMed ID: 25259925

Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

PubMed ID: 25259925

DOI: 10.1016/j.cell.2014.08.038

PubMed ID: 23723238

Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

PubMed ID: 23723238

DOI: 10.1126/science.1232044

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

Sequence Information:

Length: 374
Mass: 43250
Checksum: 0D32F7D86E2A00DE
Sequence:

MEESDSEKTT EKENLGPRMD PPLGEPEGSL GWVLPNTAMK KKVLLMGKSG SGKTSMRSII 
FANYIARDTR RLGATILDRI HSLQINSSLS TYSLVDSVGN TKTFDVEHSH VRFLGNLVLN 
LWDCGGQDTF MENYFTSQRD NIFRNVEVLI YVFDVESREL EKDMHYYQSC LEAILQNSPD 
AKIFCLVHKM DLVQEDQRDL IFKEREEDLR RLSRPLECSC FRTSIWDETL YKAWSSIVYQ 
LIPNVQQLEM NLRNFAEIIE ADEVLLFERA TFLVISHYQC KEQRDAHRFE KISNIIKQFK 
LSCSKLAASF QSMEVRNSNF AAFIDIFTSN TYVMVVMSDP SIPSAATLIN IRNARKHFEK 
LERVDGPKQC LLMR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RRAGB

Associated with

Other Information

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. PubMed ID: 7499430

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. PubMed ID: 9394008

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. PubMed ID: 11073942

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. PubMed ID: 18497260

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. PubMed ID: 20381137

Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. PubMed ID: 22980980

SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. PubMed ID: 22575674

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. PubMed ID: 24095279

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. PubMed ID: 25259925

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. PubMed ID: 23723238

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. PubMed ID: 25561175

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. PubMed ID: 25567906