Details for: EMC8

Gene ID: 10328

Symbol: EMC8

Ensembl ID: ENSG00000131148

Description: ER membrane protein complex subunit 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.33
    Marker Score: 2,277
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.19
    Marker Score: 808
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.13
    Marker Score: 1,414
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.12
    Marker Score: 4,414
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.09
    Marker Score: 1,566
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.09
    Marker Score: 1,310
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.05
    Marker Score: 303
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1
    Marker Score: 499
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,676
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,901
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 1,000
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1,419
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.96
    Marker Score: 2,023
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.95
    Marker Score: 2,573
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.93
    Marker Score: 3,457
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.93
    Marker Score: 32,197
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.93
    Marker Score: 852
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.92
    Marker Score: 991
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.92
    Marker Score: 971
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.92
    Marker Score: 442
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.91
    Marker Score: 857
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,168
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,685
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.89
    Marker Score: 948
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2,406
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.87
    Marker Score: 2,064
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.86
    Marker Score: 2,034
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.86
    Marker Score: 475
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.86
    Marker Score: 1,801
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.86
    Marker Score: 3,508
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.85
    Marker Score: 638
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.85
    Marker Score: 443
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.85
    Marker Score: 534
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.84
    Marker Score: 945
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.84
    Marker Score: 789
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.83
    Marker Score: 607
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.83
    Marker Score: 887
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.83
    Marker Score: 2,067
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.83
    Marker Score: 865
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.83
    Marker Score: 359
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.82
    Marker Score: 2,443
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.82
    Marker Score: 3,544
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.82
    Marker Score: 9,232
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12,675
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.81
    Marker Score: 1,373
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8
    Marker Score: 1,966
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8
    Marker Score: 8,085
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8
    Marker Score: 3,094
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.79
    Marker Score: 237
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.79
    Marker Score: 803
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.79
    Marker Score: 1,370
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 525
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.75
    Marker Score: 19,263
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.75
    Marker Score: 669
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.75
    Marker Score: 411
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.75
    Marker Score: 2,886
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.74
    Marker Score: 4,737
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.74
    Marker Score: 469
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.73
    Marker Score: 6,334
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.73
    Marker Score: 172
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.73
    Marker Score: 357
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.73
    Marker Score: 254
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.73
    Marker Score: 360
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.71
    Marker Score: 3,429
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.71
    Marker Score: 559
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.71
    Marker Score: 1,412
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7
    Marker Score: 23,747
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.7
    Marker Score: 340
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7
    Marker Score: 320
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.7
    Marker Score: 463
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.7
    Marker Score: 172
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7
    Marker Score: 38,894
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.69
    Marker Score: 234
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.69
    Marker Score: 280
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.68
    Marker Score: 1,089
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1,610
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.68
    Marker Score: 1,120
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.68
    Marker Score: 264
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.68
    Marker Score: 497
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.68
    Marker Score: 2,127
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 446
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.67
    Marker Score: 161
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.67
    Marker Score: 420
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 610
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.67
    Marker Score: 671
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.67
    Marker Score: 277

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EMC8 is a transmembrane protein, with a stop-transfer membrane-anchor sequence that facilitates its insertion into the ER membrane. This unique feature allows EMC8 to interact with other ER membrane proteins, forming a complex that regulates ER function. The subunit is significantly expressed in various cell types, including pancreatic A cells, proerythroblasts, and osteoclasts, highlighting its importance in different cellular processes. **Pathways and Functions:** EMC8 is involved in several key pathways, including: 1. **Membrane Insertion:** EMC8's stop-transfer membrane-anchor sequence enables its insertion into the ER membrane, where it interacts with other ER membrane proteins to regulate ER function. 2. **Protein Binding:** EMC8 binds to various proteins, including those involved in protein folding and lipid synthesis, thereby modulating ER function. 3. **Endoplasmic Reticulum Stress Response:** EMC8 plays a role in the ER stress response, helping to maintain ER homeostasis and prevent ER stress-induced apoptosis. **Clinical Significance:** Dysregulation of EMC8 has been implicated in various diseases, including: 1. **Diabetes:** Mutations in EMC8 have been linked to pancreatic A-cell dysfunction, leading to impaired insulin secretion and diabetes. 2. **Neurological Disorders:** EMC8 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where ER stress and dysfunction play a key role. 3. **Bone Diseases:** EMC8 has been linked to osteoclast dysfunction, leading to bone diseases such as osteoporosis. In conclusion, EMC8 is a critical component of the ER membrane complex, playing a pivotal role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of EMC8 in maintaining ER function and overall health. Further research is needed to fully elucidate the mechanisms by which EMC8 regulates ER function and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 4282073540

Symbol: EMC8_HUMAN

Name: ER membrane protein complex subunit 8

UniProtKB Accession Codes:

O43402 C9JB21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10337626

Title: The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4.

PubMed ID: 10337626

DOI: 10.1007/s003359901031

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22119785

Title: Defining human ERAD networks through an integrative mapping strategy.

PubMed ID: 22119785

DOI: 10.1038/ncb2383

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30415835

Title: EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.

PubMed ID: 30415835

DOI: 10.1016/j.cell.2018.10.009

PubMed ID: 29809151

Title: The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

PubMed ID: 29809151

DOI: 10.7554/elife.37018

PubMed ID: 29242231

Title: The ER membrane protein complex is a transmembrane domain insertase.

PubMed ID: 29242231

DOI: 10.1126/science.aao3099

PubMed ID: 32459176

Title: The architecture of EMC reveals a path for membrane protein insertion.

PubMed ID: 32459176

DOI: 10.7554/elife.57887

PubMed ID: 32439656

Title: Structural basis for membrane insertion by the human ER membrane protein complex.

PubMed ID: 32439656

DOI: 10.1126/science.abb5008

Sequence Information:

  • Length: 210
  • Mass: 23773
  • Checksum: 41367FDD98769250
  • Sequence:
    • MPGVKLTTQA YCKMVLHGAK YPHCAVNGLL VAEKQKPRKE HLPLGGPGAH HTLFVDCIPL 
FHGTLALAPM LEVALTLIDS WCKDHSYVIA GYYQANERVK DASPNQVAEK VASRIAEGFS 
DTALIMVDNT KFTMDCVAPT IHVYEHHENR WRCRDPHHDY CEDWPEAQRI SASLLDSRSY 
ETLVDFDNHL DDIRNDWTNP EINKAVLHLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.