Details for: CDKN3

Gene ID: 1033

Symbol: CDKN3

Ensembl ID: ENSG00000100526

Description: cyclin dependent kinase inhibitor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.8234
    Cell Significance Index: -9.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.6057
    Cell Significance Index: -9.5900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 14.1193
    Cell Significance Index: 6.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9832
    Cell Significance Index: -8.6100
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 6.2105
    Cell Significance Index: 4.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1510
    Cell Significance Index: -11.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6812
    Cell Significance Index: -10.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5507
    Cell Significance Index: 182.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2217
    Cell Significance Index: 132.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1032
    Cell Significance Index: 9.4800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9430
    Cell Significance Index: 7.1200
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.9247
    Cell Significance Index: 2.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9050
    Cell Significance Index: 817.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8127
    Cell Significance Index: 26.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7616
    Cell Significance Index: 8.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5675
    Cell Significance Index: 66.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5458
    Cell Significance Index: 37.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5254
    Cell Significance Index: 51.9700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.5155
    Cell Significance Index: 2.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4138
    Cell Significance Index: 14.3800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.4071
    Cell Significance Index: 1.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3765
    Cell Significance Index: 7.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3268
    Cell Significance Index: 9.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3202
    Cell Significance Index: 8.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3166
    Cell Significance Index: 62.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3081
    Cell Significance Index: 3.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2793
    Cell Significance Index: 14.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2365
    Cell Significance Index: 129.1700
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.1802
    Cell Significance Index: 0.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1798
    Cell Significance Index: 3.8300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1788
    Cell Significance Index: 2.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1779
    Cell Significance Index: 33.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1727
    Cell Significance Index: 9.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1656
    Cell Significance Index: 4.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1528
    Cell Significance Index: 9.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1208
    Cell Significance Index: 24.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1064
    Cell Significance Index: 2.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1026
    Cell Significance Index: 45.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0866
    Cell Significance Index: 2.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0628
    Cell Significance Index: 4.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0615
    Cell Significance Index: 22.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0444
    Cell Significance Index: 1.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0251
    Cell Significance Index: 0.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0242
    Cell Significance Index: 3.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0208
    Cell Significance Index: 0.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0168
    Cell Significance Index: 2.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0093
    Cell Significance Index: 1.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0090
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0083
    Cell Significance Index: 5.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0024
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0121
    Cell Significance Index: -0.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0121
    Cell Significance Index: -0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0133
    Cell Significance Index: -2.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0141
    Cell Significance Index: -10.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0178
    Cell Significance Index: -5.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0192
    Cell Significance Index: -10.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0206
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0218
    Cell Significance Index: -13.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0254
    Cell Significance Index: -3.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0286
    Cell Significance Index: -1.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0381
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0480
    Cell Significance Index: -8.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0594
    Cell Significance Index: -12.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0597
    Cell Significance Index: -1.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0642
    Cell Significance Index: -0.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0690
    Cell Significance Index: -4.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0698
    Cell Significance Index: -4.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0703
    Cell Significance Index: -4.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0735
    Cell Significance Index: -2.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0846
    Cell Significance Index: -1.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0892
    Cell Significance Index: -1.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0951
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0956
    Cell Significance Index: -10.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0994
    Cell Significance Index: -10.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1156
    Cell Significance Index: -8.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1185
    Cell Significance Index: -7.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1327
    Cell Significance Index: -10.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1352
    Cell Significance Index: -7.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1422
    Cell Significance Index: -8.7200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1515
    Cell Significance Index: -2.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1543
    Cell Significance Index: -8.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1722
    Cell Significance Index: -4.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1838
    Cell Significance Index: -8.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1892
    Cell Significance Index: -8.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1945
    Cell Significance Index: -5.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1996
    Cell Significance Index: -2.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2034
    Cell Significance Index: -3.0700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2123
    Cell Significance Index: -1.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2239
    Cell Significance Index: -8.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2253
    Cell Significance Index: -3.7900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2440
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDKN3 is a dual-specificity phosphatase that specifically targets cyclin-dependent kinases (CDKs), which are essential enzymes for cell cycle progression. CDKN3 inhibits the activity of CDKs by dephosphorylating and thereby inactivating them. This inhibition prevents the phosphorylation and activation of cyclins, which are required for the transition from the G1 phase to the S phase of the cell cycle. CDKN3 is unique in that it is associated with CDK2, a key regulator of the cell cycle. **Pathways and Functions:** CDKN3 is involved in several key pathways, including: 1. **G1/S transition of the mitotic cell cycle**: CDKN3 inhibits the activity of CDK2, preventing the transition from the G1 phase to the S phase of the cell cycle. 2. **Negative regulation of cell population proliferation**: CDKN3 acts as a brake on cell proliferation by inhibiting the activity of CDK2, thereby preventing excessive cell growth. 3. **Regulation of cyclin-dependent protein serine/threonine kinase activity**: CDKN3 specifically targets CDK2, a key regulator of the cell cycle, and inhibits its activity. 4. **Myosin phosphatase activity**: CDKN3 is involved in the regulation of myosin phosphatase activity, which is essential for muscle contraction and relaxation. 5. **Protein binding and serine/threonine phosphatase activity**: CDKN3 can bind to various proteins and exert its phosphatase activity, regulating their function. **Clinical Significance:** The dysregulation of CDKN3 has been implicated in several diseases, including: 1. **Cancer**: CDKN3 is often downregulated in cancer cells, leading to uncontrolled cell growth and tumor formation. 2. **Autoimmune disorders**: CDKN3 has been implicated in autoimmune disorders, such as rheumatoid arthritis, where it is thought to contribute to the development of autoantibodies. 3. **Neurological disorders**: CDKN3 has been implicated in neurological disorders, such as Alzheimer's disease, where it is thought to contribute to the development of cognitive decline. In conclusion, CDKN3 is a critical regulator of cell cycle and proliferation, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which CDKN3 regulates cell proliferation and to explore its therapeutic potential in the treatment of various diseases.

Genular Protein ID: 234627098

Symbol: CDKN3_HUMAN

Name: CDK2-associated dual-specificity phosphatase

UniProtKB Accession Codes:

Q16667 Q53ZU6 Q5U0M4 Q6P1N8 Q99585 Q9BPW7 Q9BY36 Q9C042 Q9C046 Q9C047 Q9C049 Q9C051 Q9C053

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 21 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8242750

Title: Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.

PubMed ID: 8242750

DOI: 10.1016/0092-8674(93)90498-f

PubMed ID: 8127873

Title: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

PubMed ID: 8127873

DOI: 10.1073/pnas.91.5.1731

PubMed ID: 10987270

Title: Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.

PubMed ID: 10987270

PubMed ID: 12745075

Title: Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant.

PubMed ID: 12745075

DOI: 10.1016/s0006-291x(03)00757-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7569954

Title: Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin.

PubMed ID: 7569954

DOI: 10.1126/science.270.5233.90

PubMed ID: 10669749

Title: Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression.

PubMed ID: 10669749

DOI: 10.1128/mcb.20.5.1723-1732.2000

PubMed ID: 11781350

Title: Human HTm4 is a hematopoietic cell cycle regulator.

PubMed ID: 11781350

DOI: 10.1172/jci14025

PubMed ID: 15671017

Title: Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.

PubMed ID: 15671017

DOI: 10.1074/jbc.m413437200

PubMed ID: 11463386

Title: Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.

PubMed ID: 11463386

DOI: 10.1016/s1097-2765(01)00208-8

Sequence Information:

  • Length: 212
  • Mass: 23805
  • Checksum: D87FAC8E28F6525F
  • Sequence:
    • MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV 
QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC 
EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI 
QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR

Genular Protein ID: 3902763745

Symbol: G3V2J7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V2J7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PROSITE 4 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 203
  • Mass: 22513
  • Checksum: 0EFA3B04945D9EC8
  • Sequence:
    • MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV 
QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC 
EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI 
QTIKDLPTSQ FLPQSVLGMD PLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.