CDKN3 | ENSG00000100526 | NCBI 1033

Details for: CDKN3

Gene ID: 1033

Symbol: CDKN3

Ensembl ID: ENSG00000100526

Description: cyclin dependent kinase inhibitor 3

Associated with

Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dephosphorylation
(GO:0016311)
G1/s transition of mitotic cell cycle
(GO:0000082)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of cell population proliferation
(GO:0008285)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein tyrosine/serine/threonine phosphatase activity
(GO:0008138)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cell cycle
(GO:0051726)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)

Other Information

Proteins

CDK2-associated dual-specificity phosphatase
G3V2J7_HUMAN

Genular Protein ID: 234627098

Symbol: CDKN3_HUMAN

Name: CDK2-associated dual-specificity phosphatase

UniProtKB Accession Codes:

Q16667 Q53ZU6 Q5U0M4 Q6P1N8 Q99585 Q9BPW7 Q9BY36 Q9C042 Q9C046 Q9C047 Q9C049 Q9C051 Q9C053

Database IDs:

Citations:

PubMed ID: 8242750

Title: Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.

PubMed ID: 8242750

DOI: 10.1016/0092-8674(93)90498-f

PubMed ID: 8127873

Title: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

PubMed ID: 8127873

DOI: 10.1073/pnas.91.5.1731

PubMed ID: 10987270

Title: Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.

PubMed ID: 10987270

PubMed ID: 12745075

Title: Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant.

PubMed ID: 12745075

DOI: 10.1016/s0006-291x(03)00757-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7569954

Title: Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin.

PubMed ID: 7569954

DOI: 10.1126/science.270.5233.90

PubMed ID: 10669749

Title: Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression.

PubMed ID: 10669749

DOI: 10.1128/mcb.20.5.1723-1732.2000

PubMed ID: 11781350

Title: Human HTm4 is a hematopoietic cell cycle regulator.

PubMed ID: 11781350

DOI: 10.1172/jci14025

PubMed ID: 15671017

Title: Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.

PubMed ID: 15671017

DOI: 10.1074/jbc.m413437200

PubMed ID: 11463386

Title: Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.

PubMed ID: 11463386

DOI: 10.1016/s1097-2765(01)00208-8

Sequence Information:

Length: 212
Mass: 23805
Checksum: D87FAC8E28F6525F
Sequence:

MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV 
QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC 
EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI 
QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR

Genular Protein ID: 3902763745

Symbol: G3V2J7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V2J7

Database IDs:

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

Length: 203
Mass: 22513
Checksum: 0EFA3B04945D9EC8
Sequence:

MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV 
QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC 
EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI 
QTIKDLPTSQ FLPQSVLGMD PLT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDKN3

Associated with

Other Information

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. PubMed ID: 8242750

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. PubMed ID: 8127873

Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. PubMed ID: 10987270

Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. PubMed ID: 12745075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. PubMed ID: 7569954

Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. PubMed ID: 10669749

Human HTm4 is a hematopoietic cell cycle regulator. PubMed ID: 11781350

Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. PubMed ID: 15671017

Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. PubMed ID: 11463386

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121