CLEC4M | ENSG00000104938 | NCBI 10332

Details for: CLEC4M

Gene ID: 10332

Symbol: CLEC4M

Ensembl ID: ENSG00000104938

Description: C-type lectin domain family 4 member M

Associated with

Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation
(GO:0019882)
Biological process involved in interspecies interaction between organisms
(GO:0044419)
Calcium-dependent protein binding
(GO:0048306)
Carbohydrate binding
(GO:0030246)
Cell-cell recognition
(GO:0009988)
Cytoplasm
(GO:0005737)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Host cell
(GO:0043657)
Icam-3 receptor activity
(GO:0030369)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Intracellular signal transduction
(GO:0035556)
Intracellular transport of virus
(GO:0075733)
Leukocyte cell-cell adhesion
(GO:0007159)
Mannose binding
(GO:0005537)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Peptide antigen binding
(GO:0042605)
Peptide antigen transport
(GO:0046968)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Receptor-mediated virion attachment to host cell
(GO:0046813)
Signaling receptor activity
(GO:0038023)
Symbiont entry into host cell
(GO:0046718)
Viral genome replication
(GO:0019079)
Virion attachment to host cell
(GO:0019062)
Virion binding
(GO:0046790)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

C-type lectin domain family 4 member M

Genular Protein ID: 903674492

Symbol: CLC4M_HUMAN

Name: C-type lectin domain family 4 member M

UniProtKB Accession Codes:

Q9H2X3 A6NKI4 A8K8B3 Q69F40 Q969M4 Q96QP3 Q96QP4 Q96QP5 Q96QP6 Q9BXS3 Q9H2Q9 Q9H8F0 Q9Y2A8

Database IDs:

Citations:

PubMed ID: 10072769

Title: Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.

PubMed ID: 10072769

DOI: 10.1016/s0378-1119(99)00004-9

PubMed ID: 10975799

Title: DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13.

PubMed ID: 10975799

DOI: 10.4049/jimmunol.165.6.2937

PubMed ID: 11337487

Title: Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.

PubMed ID: 11337487

DOI: 10.1074/jbc.m009807200

PubMed ID: 11257134

Title: A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.

PubMed ID: 11257134

DOI: 10.1084/jem.193.6.671

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11226297

Title: DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.

PubMed ID: 11226297

DOI: 10.1073/pnas.051631398

PubMed ID: 11384997

Title: A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.

PubMed ID: 11384997

DOI: 10.1074/jbc.m104565200

PubMed ID: 12433371

Title: Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.

PubMed ID: 12433371

DOI: 10.1016/s1074-7613(02)00447-8

PubMed ID: 12050398

Title: C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.

PubMed ID: 12050398

DOI: 10.1128/jvi.76.13.6841-6844.2002

PubMed ID: 12502850

Title: Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.

PubMed ID: 12502850

DOI: 10.1128/jvi.77.2.1337-1346.2003

PubMed ID: 15479853

Title: DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.

PubMed ID: 15479853

DOI: 10.1128/jvi.78.21.12090-12095.2004

PubMed ID: 15371595

Title: L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.

PubMed ID: 15371595

DOI: 10.1073/pnas.0405695101

PubMed ID: 15496474

Title: CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.

PubMed ID: 15496474

DOI: 10.1073/pnas.0403812101

PubMed ID: 16816373

Title: Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.

PubMed ID: 16816373

DOI: 10.2353/ajpath.2006.051191

PubMed ID: 17037540

Title: Human coronavirus 229E can use CD209L (L-SIGN) to enter cells.

PubMed ID: 17037540

DOI: 10.1007/978-0-387-33012-9_44

PubMed ID: 16415006

Title: West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.

PubMed ID: 16415006

DOI: 10.1128/jvi.80.3.1290-1301.2006

PubMed ID: 21203928

Title: Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG.

PubMed ID: 21203928

DOI: 10.1007/s13238-010-0101-3

PubMed ID: 21277928

Title: Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission.

PubMed ID: 21277928

DOI: 10.1016/j.humimm.2011.01.012

PubMed ID: 21191006

Title: N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.

PubMed ID: 21191006

DOI: 10.1128/jvi.01705-10

PubMed ID: 24623090

Title: Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.

PubMed ID: 24623090

DOI: 10.1007/s00705-014-2042-2

PubMed ID: 11739956

Title: Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.

PubMed ID: 11739956

DOI: 10.1126/science.1066371

PubMed ID: 15509576

Title: Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.

PubMed ID: 15509576

DOI: 10.1074/jbc.m409925200

PubMed ID: 15784257

Title: The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer.

PubMed ID: 15784257

DOI: 10.1016/j.jmb.2005.01.063

Sequence Information:

Length: 399
Mass: 45350
Checksum: 0FADC99F72AEA593
Sequence:

MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA LVLQLLSFML 
LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK 
AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE 
IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE 
LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR 
AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP 
NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CLEC4M

Associated with

Other Information

Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. PubMed ID: 10072769

DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13. PubMed ID: 10975799

Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. PubMed ID: 11337487

A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. PubMed ID: 11257134

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. PubMed ID: 11226297

A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. PubMed ID: 11384997

Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. PubMed ID: 12433371

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. PubMed ID: 12050398

Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR. PubMed ID: 12502850

DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus. PubMed ID: 15479853

L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. PubMed ID: 15371595

CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. PubMed ID: 15496474

Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. PubMed ID: 16816373

Human coronavirus 229E can use CD209L (L-SIGN) to enter cells. PubMed ID: 17037540

West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection. PubMed ID: 16415006

Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG. PubMed ID: 21203928

Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission. PubMed ID: 21277928

N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN. PubMed ID: 21191006

Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin. PubMed ID: 24623090

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. PubMed ID: 11739956

Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. PubMed ID: 15509576

The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer. PubMed ID: 15784257