Details for: CLEC4M

Gene ID: 10332

Symbol: CLEC4M

Ensembl ID: ENSG00000104938

Description: C-type lectin domain family 4 member M

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.75
    Marker Score: 1208.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.44
    Marker Score: 8556.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.41
    Marker Score: 3840
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.14
    Marker Score: 722.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.1
    Marker Score: 1178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2170
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.06
    Marker Score: 231
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2584
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.89
    Marker Score: 679
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.76
    Marker Score: 819
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.66
    Marker Score: 381
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1039
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.51
    Marker Score: 233
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.43
    Marker Score: 4333
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 241
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5302
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 327
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3
    Marker Score: 5362
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3
    Marker Score: 165
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.29
    Marker Score: 308
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.27
    Marker Score: 292
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.27
    Marker Score: 138
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 154
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.15
    Marker Score: 155
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.13
    Marker Score: 63
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.13
    Marker Score: 35.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.11
    Marker Score: 482
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.11
    Marker Score: 281
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 103
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.09
    Marker Score: 134
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.09
    Marker Score: 152
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 77
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.08
    Marker Score: 80
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 148
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.05
    Marker Score: 351
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.05
    Marker Score: 108
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.05
    Marker Score: 97
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.05
    Marker Score: 77
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 72
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 88
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17

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Other Information

**Key characteristics:** - It is a transmembrane protein with a conserved C-type lectin domain. - It is expressed in high levels in conventional dendritic cells, Sertoli cells, ovarian surface epithelial cells, and endothelial cells of the liver sinusoid. - It is involved in the regulation of immune responses to viral infections. **Pathways and functions:** - CLEC4M is involved in the adaptive immune response by binding to mannose molecules presented on the surface of antigen-presenting cells. This binding triggers the activation of dendritic cells, leading to the initiation of an adaptive immune response. - It is involved in calcium-dependent protein binding by interacting with calcium ions. Calcium signaling is a critical signaling pathway involved in inflammation and immune responses. - It is involved in carbohydrate binding by interacting with mannose molecules. Mannose is a sugar molecule that is expressed on the surface of many pathogens. - It is involved in cell-cell recognition by binding to ligands expressed on adjacent cells. This interaction is important for the formation of immune synapses and the establishment of immune responses. **Clinical significance:** - Mutations in CLEC4M have been linked to the pathogenesis of several diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. - CLEC4M is a potential therapeutic target for diseases characterized by inflammatory responses, such as rheumatoid arthritis and inflammatory bowel disease. - Agents that block CLEC4M signaling have been shown to be effective in reducing inflammation and disease activity.

Genular Protein ID: 903674492

Symbol: CLC4M_HUMAN

Name: C-type lectin domain family 4 member M

UniProtKB Accession Codes:

Q9H2X3 A6NKI4 A8K8B3 Q69F40 Q969M4 Q96QP3 Q96QP4 Q96QP5 Q96QP6 Q9BXS3 Q9H2Q9 Q9H8F0 Q9Y2A8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 RNAct 1 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10072769

Title: Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.

PubMed ID: 10072769

DOI: 10.1016/s0378-1119(99)00004-9

PubMed ID: 10975799

Title: DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13.

PubMed ID: 10975799

DOI: 10.4049/jimmunol.165.6.2937

PubMed ID: 11337487

Title: Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.

PubMed ID: 11337487

DOI: 10.1074/jbc.m009807200

PubMed ID: 11257134

Title: A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.

PubMed ID: 11257134

DOI: 10.1084/jem.193.6.671

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11226297

Title: DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.

PubMed ID: 11226297

DOI: 10.1073/pnas.051631398

PubMed ID: 11384997

Title: A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.

PubMed ID: 11384997

DOI: 10.1074/jbc.m104565200

PubMed ID: 12433371

Title: Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.

PubMed ID: 12433371

DOI: 10.1016/s1074-7613(02)00447-8

PubMed ID: 12050398

Title: C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.

PubMed ID: 12050398

DOI: 10.1128/jvi.76.13.6841-6844.2002

PubMed ID: 12502850

Title: Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.

PubMed ID: 12502850

DOI: 10.1128/jvi.77.2.1337-1346.2003

PubMed ID: 15479853

Title: DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.

PubMed ID: 15479853

DOI: 10.1128/jvi.78.21.12090-12095.2004

PubMed ID: 15371595

Title: L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.

PubMed ID: 15371595

DOI: 10.1073/pnas.0405695101

PubMed ID: 15496474

Title: CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.

PubMed ID: 15496474

DOI: 10.1073/pnas.0403812101

PubMed ID: 16816373

Title: Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.

PubMed ID: 16816373

DOI: 10.2353/ajpath.2006.051191

PubMed ID: 17037540

Title: Human coronavirus 229E can use CD209L (L-SIGN) to enter cells.

PubMed ID: 17037540

DOI: 10.1007/978-0-387-33012-9_44

PubMed ID: 16415006

Title: West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.

PubMed ID: 16415006

DOI: 10.1128/jvi.80.3.1290-1301.2006

PubMed ID: 21203928

Title: Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG.

PubMed ID: 21203928

DOI: 10.1007/s13238-010-0101-3

PubMed ID: 21277928

Title: Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission.

PubMed ID: 21277928

DOI: 10.1016/j.humimm.2011.01.012

PubMed ID: 21191006

Title: N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.

PubMed ID: 21191006

DOI: 10.1128/jvi.01705-10

PubMed ID: 24623090

Title: Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.

PubMed ID: 24623090

DOI: 10.1007/s00705-014-2042-2

PubMed ID: 11739956

Title: Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.

PubMed ID: 11739956

DOI: 10.1126/science.1066371

PubMed ID: 15509576

Title: Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.

PubMed ID: 15509576

DOI: 10.1074/jbc.m409925200

PubMed ID: 15784257

Title: The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer.

PubMed ID: 15784257

DOI: 10.1016/j.jmb.2005.01.063

Sequence Information:

  • Length: 399
  • Mass: 45350
  • Checksum: 0FADC99F72AEA593
  • Sequence:
    • MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA LVLQLLSFML 
LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK 
AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE 
IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE 
LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR 
AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP 
NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.