TRIM22 | ENSG00000132274 | NCBI 10346

Details for: TRIM22

Gene ID: 10346

Symbol: TRIM22

Ensembl ID: ENSG00000132274

Description: tripartite motif containing 22

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Cajal body
(GO:0015030)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Negative regulation of dna-templated transcription
(GO:0045892)
Nuclear body
(GO:0016604)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein k63-linked ubiquitination
(GO:0070534)
Protein kinase binding
(GO:0019901)
Protein polyubiquitination
(GO:0000209)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of protein localization
(GO:0032880)
Regulation of viral entry into host cell
(GO:0046596)
Response to virus
(GO:0009615)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase TRIM22
B4DQS5_HUMAN

Genular Protein ID: 4218622788

Symbol: TRI22_HUMAN

Name: E3 ubiquitin-protein ligase TRIM22

UniProtKB Accession Codes:

Q8IYM9 Q05CQ0 Q15521

Database IDs:

Citations:

PubMed ID: 7797467

Title: Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression.

PubMed ID: 7797467

DOI: 10.1074/jbc.270.25.14891

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 15064739

Title: Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.

PubMed ID: 15064739

DOI: 10.1038/sj.onc.1207524

PubMed ID: 17156811

Title: Unique features of TRIM5alpha among closely related human TRIM family members.

PubMed ID: 17156811

DOI: 10.1016/j.virol.2006.10.035

PubMed ID: 18656448

Title: Identification of TRIM22 as a RING finger E3 ubiquitin ligase.

PubMed ID: 18656448

DOI: 10.1016/j.bbrc.2008.07.070

PubMed ID: 18389079

Title: The interferon response inhibits HIV particle production by induction of TRIM22.

PubMed ID: 18389079

DOI: 10.1371/journal.ppat.1000007

PubMed ID: 19331816

Title: Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies.

PubMed ID: 19331816

DOI: 10.1016/j.yexcr.2009.01.028

PubMed ID: 19481078

Title: B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies.

PubMed ID: 19481078

DOI: 10.1016/j.febslet.2009.05.036

PubMed ID: 19585648

Title: Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain.

PubMed ID: 19585648

DOI: 10.1002/hep.23011

PubMed ID: 19218198

Title: TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus.

PubMed ID: 19218198

DOI: 10.1099/vir.0.006288-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26683615

Title: HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter.

PubMed ID: 26683615

DOI: 10.1186/s12977-015-0230-0

PubMed ID: 25683609

Title: Interferon alpha (IFNalpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A.

PubMed ID: 25683609

DOI: 10.1038/cmi.2014.131

PubMed ID: 35777501

Title: TRIM22 negatively regulates MHC-II expression.

PubMed ID: 35777501

DOI: 10.1016/j.bbamcr.2022.119318

PubMed ID: 36042495

Title: TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation.

PubMed ID: 36042495

DOI: 10.1186/s13578-022-00872-w

PubMed ID: 36159777

Title: TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I.

PubMed ID: 36159777

DOI: 10.1016/j.omto.2022.08.007

Sequence Information:

Length: 498
Mass: 56947
Checksum: AFADB968DE76F7DD
Sequence:

MDFSVKVDIE KEVTCPICLE LLTEPLSLDC GHSFCQACIT AKIKESVIIS RGESSCPVCQ 
TRFQPGNLRP NRHLANIVER VKEVKMSPQE GQKRDVCEHH GKKLQIFCKE DGKVICWVCE 
LSQEHQGHQT FRINEVVKEC QEKLQVALQR LIKEDQEAEK LEDDIRQERT AWKNYIQIER 
QKILKGFNEM RVILDNEEQR ELQKLEEGEV NVLDNLAAAT DQLVQQRQDA STLISDLQRR 
LRGSSVEMLQ DVIDVMKRSE SWTLKKPKSV SKKLKSVFRV PDLSGMLQVL KELTDVQYYW 
VDVMLNPGSA TSNVAISVDQ RQVKTVRTCT FKNSNPCDFS AFGVFGCQYF SSGKYYWEVD 
VSGKIAWILG VHSKISSLNK RKSSGFAFDP SVNYSKVYSR YRPQYGYWVI GLQNTCEYNA 
FEDSSSSDPK VLTLFMAVPP CRIGVFLDYE AGIVSFFNVT NHGALIYKFS GCRFSRPAYP 
YFNPWNCLVP MTVCPPSS

Genular Protein ID: 115775958

Symbol: B4DQS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQS5

Database IDs:

Sequence Information:

Length: 349
Mass: 39970
Checksum: AF214AD6E7C64A0B
Sequence:

MDFSVKVDIE KLEDDIRQER TAWKNYIQIE RQKILKGFNE MRVILDNEEQ RELQKLEEGE 
VNVLDNLAAA TDQLVQQRQD ASMLISDLQR RLRGSSVEML QDVIDVMKRS ESWTLKKPKS 
VSKKLKSVFR VPDLSGMLQV LKELTDVQYY WVDVMLNPGS ATSNVAISVD QRQVKTVRTC 
TFKNSNPCDF SAFGVFGCQY FSSGKYYWEV DVSGKIAWIL GVHSKISSLN KRKSSGFAFD 
PSVNYSKVYS RYRPQYGYWV IGLQNTCEYN AFEDSSSSDP KVLTLFMAVP PCRIGVFLDY 
EAGIVSFFNV TNHGALIYKF SGCRFSRPAY PYFNPWNCLV PMTVCPPSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIM22

Associated with

Other Information

Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. PubMed ID: 7797467

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The tripartite motif family identifies cell compartments. PubMed ID: 11331580

Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. PubMed ID: 15064739

Unique features of TRIM5alpha among closely related human TRIM family members. PubMed ID: 17156811

Identification of TRIM22 as a RING finger E3 ubiquitin ligase. PubMed ID: 18656448

The interferon response inhibits HIV particle production by induction of TRIM22. PubMed ID: 18389079

Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies. PubMed ID: 19331816

B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies. PubMed ID: 19481078

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. PubMed ID: 19585648

TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. PubMed ID: 19218198

Initial characterization of the human central proteome. PubMed ID: 21269460

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter. PubMed ID: 26683615

Interferon alpha (IFNalpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. PubMed ID: 25683609

TRIM22 negatively regulates MHC-II expression. PubMed ID: 35777501

TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation. PubMed ID: 36042495

TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I. PubMed ID: 36159777