Details for: CDO1

Gene ID: 1036

Symbol: CDO1

Ensembl ID: ENSG00000129596

Description: cysteine dioxygenase type 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 55.4682
    Cell Significance Index: -22.8500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 14.5650
    Cell Significance Index: 90.1100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.8654
    Cell Significance Index: 26.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7078
    Cell Significance Index: 28.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6557
    Cell Significance Index: 44.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1265
    Cell Significance Index: 23.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0459
    Cell Significance Index: 11.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5798
    Cell Significance Index: 115.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5127
    Cell Significance Index: 183.8800
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.4459
    Cell Significance Index: 2.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4436
    Cell Significance Index: 23.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4397
    Cell Significance Index: 15.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4043
    Cell Significance Index: 81.1000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3216
    Cell Significance Index: 4.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1952
    Cell Significance Index: 26.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1804
    Cell Significance Index: 11.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1673
    Cell Significance Index: 2.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1606
    Cell Significance Index: 2.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1469
    Cell Significance Index: 2.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1270
    Cell Significance Index: 3.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0805
    Cell Significance Index: 3.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0794
    Cell Significance Index: 10.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0541
    Cell Significance Index: 0.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0352
    Cell Significance Index: 24.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0101
    Cell Significance Index: 18.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0055
    Cell Significance Index: 3.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0046
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0087
    Cell Significance Index: -16.2900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0130
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0147
    Cell Significance Index: -8.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0217
    Cell Significance Index: -29.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0309
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0329
    Cell Significance Index: -24.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0400
    Cell Significance Index: -11.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0417
    Cell Significance Index: -18.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0427
    Cell Significance Index: -24.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0432
    Cell Significance Index: -27.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0820
    Cell Significance Index: -14.7900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0884
    Cell Significance Index: -0.8400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0927
    Cell Significance Index: -0.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1239
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1283
    Cell Significance Index: -14.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1368
    Cell Significance Index: -28.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1402
    Cell Significance Index: -17.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1458
    Cell Significance Index: -17.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1515
    Cell Significance Index: -25.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1538
    Cell Significance Index: -17.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1556
    Cell Significance Index: -20.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1695
    Cell Significance Index: -11.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1847
    Cell Significance Index: -4.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1888
    Cell Significance Index: -19.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2210
    Cell Significance Index: -12.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2219
    Cell Significance Index: -6.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2251
    Cell Significance Index: -16.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2262
    Cell Significance Index: -23.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2529
    Cell Significance Index: -20.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2921
    Cell Significance Index: -18.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3015
    Cell Significance Index: -14.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3026
    Cell Significance Index: -19.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3207
    Cell Significance Index: -24.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3419
    Cell Significance Index: -9.8000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3577
    Cell Significance Index: -2.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3619
    Cell Significance Index: -9.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3626
    Cell Significance Index: -22.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3694
    Cell Significance Index: -7.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3739
    Cell Significance Index: -10.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3914
    Cell Significance Index: -10.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4481
    Cell Significance Index: -23.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4499
    Cell Significance Index: -14.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4719
    Cell Significance Index: -21.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4780
    Cell Significance Index: -11.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4817
    Cell Significance Index: -15.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4895
    Cell Significance Index: -13.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4985
    Cell Significance Index: -9.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5032
    Cell Significance Index: -4.7700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5057
    Cell Significance Index: -3.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5070
    Cell Significance Index: -17.7600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5186
    Cell Significance Index: -6.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5476
    Cell Significance Index: -25.5300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5541
    Cell Significance Index: -5.9600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5763
    Cell Significance Index: -6.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5864
    Cell Significance Index: -12.8400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.5887
    Cell Significance Index: -3.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6012
    Cell Significance Index: -12.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6112
    Cell Significance Index: -12.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6429
    Cell Significance Index: -23.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6567
    Cell Significance Index: -10.1600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6580
    Cell Significance Index: -9.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6678
    Cell Significance Index: -21.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6721
    Cell Significance Index: -13.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6867
    Cell Significance Index: -18.3700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.6938
    Cell Significance Index: -4.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.7146
    Cell Significance Index: -7.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7150
    Cell Significance Index: -21.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7172
    Cell Significance Index: -25.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7312
    Cell Significance Index: -18.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7752
    Cell Significance Index: -16.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDO1 is a dioxygenase enzyme that catalyzes the oxidative degradation of cysteine to form cysteine sulfinic acid, a precursor to cysteine sulfinate. This process not only regulates cysteine levels but also produces a reactive oxygen species (ROS) that can modulate inflammatory responses. The enzyme's activity is influenced by various cellular signals, including glucocorticoids, glucagon, and ethanol, highlighting its complex regulation in response to environmental cues. **Pathways and Functions:** CDO1 is implicated in several key metabolic and immune-related pathways: 1. **Cysteine metabolic process**: CDO1 is essential for regulating cysteine levels, which is crucial for maintaining cellular redox balance and preventing oxidative stress. 2. **Inflammatory response**: The ROS produced by CDO1 can modulate inflammatory responses by regulating the activity of pro-inflammatory transcription factors. 3. **L-cysteine catabolic process**: CDO1 is involved in the degradation of cysteine, which is an essential amino acid for various cellular processes, including protein synthesis and antioxidant defenses. 4. **Ferrous iron binding**: CDO1 has been shown to bind ferrous iron, which can influence its activity and regulation in response to iron availability. 5. **Response to amino acid**: CDO1 is responsive to various amino acid signals, including glutamate and aspartate, which can modulate its activity and expression. **Clinical Significance:** Dysregulation of CDO1 has been implicated in various diseases, including: 1. **Atherosclerosis**: Elevated CDO1 activity has been linked to the development of atherosclerosis, a condition characterized by the buildup of plaque in arterial walls. 2. **Inflammatory disorders**: CDO1's role in regulating inflammatory responses has been implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative diseases**: The enzyme's involvement in regulating cysteine levels and oxidative stress has been linked to the development of neurodegenerative diseases, including Alzheimer's and Parkinson's. 4. **Cancer**: CDO1's expression has been observed in various cancer types, including lung, breast, and colon cancer, highlighting its potential role in tumorigenesis and cancer progression. In conclusion, CDO1 is a critical enzyme involved in regulating cysteine metabolism, inflammatory responses, and oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3383046810

Symbol: CDO1_HUMAN

Name: Cysteine dioxygenase type 1

UniProtKB Accession Codes:

Q16878 B2RAK4 P78513 Q6FHZ8 Q8TB64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7524679

Title: Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA.

PubMed ID: 7524679

DOI: 10.1016/0167-4838(94)90144-9

PubMed ID: 10427686

Title: Human cysteine dioxygenase gene: structural organization, tissue-specific expression and downregulation by phorbol 12-myristate 13-acetate.

PubMed ID: 10427686

DOI: 10.1271/bbb.63.1017

PubMed ID: 9497919

Title: Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene.

PubMed ID: 9497919

DOI: 10.1136/mp.50.5.269

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17135237

Title: An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor.

PubMed ID: 17135237

DOI: 10.1074/jbc.m609337200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 200
  • Mass: 22972
  • Checksum: E4EF87221D05C14D
  • Sequence:
    • MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY AKFDQYRYTR 
NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG NLKETLFAWP DKKSNEMVKK 
SERVLRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT 
FHSKFGIRTP NATSGSLENN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.