Details for: MICU1
Associated with
Other Information
Genular Protein ID: 42854536
Symbol: MICU1_HUMAN
Name: Calcium uptake protein 1, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9806765
Title: Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.
PubMed ID: 9806765
PubMed ID: 16002733
Title: Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity.
PubMed ID: 16002733
PubMed ID: 20693986
Title: MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.
PubMed ID: 20693986
DOI: 10.1038/nature09358
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21685886
Title: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
PubMed ID: 21685886
DOI: 10.1038/nature10234
PubMed ID: 23101630
Title: MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
PubMed ID: 23101630
PubMed ID: 22904319
Title: Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells.
PubMed ID: 22904319
PubMed ID: 23178883
Title: MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism.
PubMed ID: 23178883
DOI: 10.1038/ncb2622
PubMed ID: 23747253
Title: MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2+) uniporter.
PubMed ID: 23747253
PubMed ID: 24332854
Title: MICU1 motifs define mitochondrial calcium uniporter binding and activity.
PubMed ID: 24332854
PubMed ID: 24231807
Title: EMRE is an essential component of the mitochondrial calcium uniporter complex.
PubMed ID: 24231807
PubMed ID: 24313810
Title: Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.
PubMed ID: 24313810
DOI: 10.1042/bj20131025
PubMed ID: 24503055
Title: MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.
PubMed ID: 24503055
PubMed ID: 24430870
Title: SLC25A23 augments mitochondrial Ca(2+) uptake, interacts with MCU, and induces oxidative stress-mediated cell death.
PubMed ID: 24430870
PubMed ID: 24560927
Title: MICU1 and MICU2 finely tune the mitochondrial Ca(2+) uniporter by exerting opposite effects on MCU activity.
PubMed ID: 24560927
PubMed ID: 24336167
Title: Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
PubMed ID: 24336167
DOI: 10.1038/ng.2851
PubMed ID: 26387864
Title: The Ca(2+)-dependent release of the Mia40-induced MICU1-MICU2 dimer from MCU regulates mitochondrial Ca(2+) uptake.
PubMed ID: 26387864
PubMed ID: 26341627
Title: Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter.
PubMed ID: 26341627
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26489515
Title: Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).
PubMed ID: 26489515
DOI: 10.1038/srep15602
PubMed ID: 26903221
Title: Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake.
PubMed ID: 26903221
PubMed ID: 26774479
Title: EMRE is a matrix Ca(2+) sensor that governs gatekeeping of the mitochondrial Ca(2+) uniporter.
PubMed ID: 26774479
PubMed ID: 27099988
Title: Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.
PubMed ID: 27099988
DOI: 10.7554/elife.15545
PubMed ID: 27123478
Title: Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood.
PubMed ID: 27123478
PubMed ID: 24514027
Title: Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.
PubMed ID: 24514027
Sequence Information:
- Length: 476
- Mass: 54351
- Checksum: D83C3A38F4B28FDF
- Sequence:
MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL LWKRAHAESP PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK KKRSGFRDRK VMEYENRIRA YSTPDKIFRY FATLKVISEP GEAEVFMTPE DFVRSITPNE KQPEHLGLDQ YIIKRFDGKK ISQEREKFAD EGSIFYTLGE CGLISFSDYI FLTTVLSTPQ RNFEIAFKMF DLNGDGEVDM EEFEQVQSII RSQTSMGMRH RDRPTTGNTL KSGLCSALTT YFFGADLKGK LTIKNFLEFQ RKLQHDVLKL EFERHDPVDG RITERQFGGM LLAYSGVQSK KLTAMQRQLK KHFKEGKGLT FQEVENFFTF LKNINDVDTA LSFYHMAGAS LDKVTMQQVA RTVAKVELSD HVCDVVFALF DCDGNGELSN KEFVSIMKQR LMRGLEKPKD MGFTRLMQAM WKCAQETAWD FALPKQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.