SEMA3A | ENSG00000075213 | NCBI 10371

Details for: SEMA3A

Gene ID: 10371

Symbol: SEMA3A

Ensembl ID: ENSG00000075213

Description: semaphorin 3A

Associated with

Crmps in sema3a signaling
(R-HSA-399956)
Developmental biology
(R-HSA-1266738)
Nervous system development
(R-HSA-9675108)
Sema3a-plexin repulsion signaling by inhibiting integrin adhesion
(R-HSA-399955)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Axon
(GO:0030424)
Axon extension involved in axon guidance
(GO:0048846)
Axon guidance
(GO:0007411)
Axonogenesis involved in innervation
(GO:0060385)
Basal dendrite arborization
(GO:0150020)
Branchiomotor neuron axon guidance
(GO:0021785)
Chemorepellent activity
(GO:0045499)
Dendrite
(GO:0030425)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Facial nerve structural organization
(GO:0021612)
Glutamatergic synapse
(GO:0098978)
Motor neuron axon guidance
(GO:0008045)
Negative chemotaxis
(GO:0050919)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Negative regulation of neuron projection development
(GO:0010977)
Nerve development
(GO:0021675)
Neural crest cell migration
(GO:0001755)
Neural crest cell migration involved in autonomic nervous system development
(GO:1901166)
Neuron migration
(GO:0001764)
Neuropilin binding
(GO:0038191)
Olfactory bulb development
(GO:0021772)
Plasma membrane
(GO:0005886)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of neuron migration
(GO:2001224)
Regulation of axon extension involved in axon guidance
(GO:0048841)
Semaphorin-plexin signaling pathway
(GO:0071526)
Semaphorin receptor binding
(GO:0030215)
Sensory system development
(GO:0048880)
Sympathetic ganglion development
(GO:0061549)
Sympathetic nervous system development
(GO:0048485)
Sympathetic neuron projection extension
(GO:0097490)
Sympathetic neuron projection guidance
(GO:0097491)
Trigeminal nerve structural organization
(GO:0021637)

Other Information

Proteins

Semaphorin-3A

Genular Protein ID: 1632626055

Symbol: SEM3A_HUMAN

Name: Semaphorin-3A

UniProtKB Accession Codes:

Q14563

Database IDs:

Citations:

PubMed ID: 8269517

Title: The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules.

PubMed ID: 8269517

DOI: 10.1016/0092-8674(93)90625-z

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 22416012

Title: SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development.

PubMed ID: 22416012

DOI: 10.1093/humrep/des022

PubMed ID: 28270793

Title: Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury.

PubMed ID: 28270793

DOI: 10.3389/fneur.2017.00049

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 22927827

Title: SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

PubMed ID: 22927827

DOI: 10.1371/journal.pgen.1002896

PubMed ID: 25077900

Title: The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.

PubMed ID: 25077900

DOI: 10.1210/jc.2014-2110

Sequence Information:

Length: 771
Mass: 88889
Checksum: 9985F8D3EAED8456
Sequence:

MGWLTRIVCL FWGVLLTARA NYQNGKNNVP RLKLSYKEML ESNNVITFNG LANSSSYHTF 
LLDEERSRLY VGAKDHIFSF DLVNIKDFQK IVWPVSYTRR DECKWAGKDI LKECANFIKV 
LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP EDNIFKLENS HFENGRGKSP YDPKLLTASL 
LIDGELYSGT AADFMGRDFA IFRTLGHHHP IRTEQHDSRW LNDPKFISAH LISESDNPED 
DKVYFFFREN AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG 
IDTHFDELQD VFLMNFKDPK NPVVYGVFTT SSNIFKGSAV CMYSMSDVRR VFLGPYAHRD 
GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI TFARSHPAMY NPVFPMNNRP 
IVIKTDVNYQ FTQIVVDRVD AEDGQYDVMF IGTDVGTVLK VVSIPKETWY DLEEVLLEEM 
TVFREPTAIS AMELSTKQQQ LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS 
ACSRYFPTAK RRTRRQDIRN GDPLTHCSDL HHDNHHGHSP EERIIYGVEN SSTFLECSPK 
SQRALVYWQF QRRNEERKEE IRVDDHIIRT DQGLLLRSLQ QKDSGNYLCH AVEHGFIQTL 
LKVTLEVIDT EHLEELLHKD DDGDGSKTKE MSNSMTPSQK VWYRDFMQLI NHPNLNTMDE 
FCEQVWKRDR KQRRQRPGHT PGNSNKWKHL QENKKGRNRR THEFERAPRS V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEMA3A

Associated with

Other Information

The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. PubMed ID: 8269517

The DNA sequence of human chromosome 7. PubMed ID: 12853948

SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development. PubMed ID: 22416012

Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury. PubMed ID: 28270793

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. PubMed ID: 21248752

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome. PubMed ID: 22927827

The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients. PubMed ID: 25077900