TUBA1B | ENSG00000123416 | NCBI 10376

Details for: TUBA1B

Gene ID: 10376

Symbol: TUBA1B

Ensembl ID: ENSG00000123416

Description: tubulin alpha 1b

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Protein folding
(R-HSA-391251)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Rhoh gtpase cycle
(R-HSA-9013407)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Cytoskeleton-dependent intracellular transport
(GO:0030705)
Double-stranded rna binding
(GO:0003725)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Microtubule-based process
(GO:0007017)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Protein binding
(GO:0005515)
Structural constituent of cytoskeleton
(GO:0005200)
Structural molecule activity
(GO:0005198)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Tubulin alpha-1B chain

Genular Protein ID: 2199757415

Symbol: TBA1B_HUMAN

Name: Tubulin alpha-1B chain

UniProtKB Accession Codes:

P68363 P04687 P05209 Q27I68 Q8WU19

Database IDs:

Citations:

PubMed ID: 6646120

Title: Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.

PubMed ID: 6646120

DOI: 10.1128/mcb.3.10.1738-1745.1983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8619814

Title: C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.

PubMed ID: 8619814

DOI: 10.1006/bbrc.1996.0211

PubMed ID: 10339593

Title: Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury.

PubMed ID: 10339593

DOI: 10.1073/pnas.96.11.6365

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 24906155

Title: Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.

PubMed ID: 24906155

DOI: 10.1016/j.cell.2014.03.061

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25908662

Title: Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

PubMed ID: 25908662

DOI: 10.1126/science.aaa5175

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 27518565

Title: Dual chromatin and cytoskeletal remodeling by SETD2.

PubMed ID: 27518565

DOI: 10.1016/j.cell.2016.07.005

PubMed ID: 26972003

Title: Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons.

PubMed ID: 26972003

DOI: 10.1016/j.celrep.2016.02.046

PubMed ID: 29146869

Title: Vasohibins encode tubulin detyrosinating activity.

PubMed ID: 29146869

DOI: 10.1126/science.aao5676

PubMed ID: 32747782

Title: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.

PubMed ID: 32747782

DOI: 10.1038/s41594-020-0462-0

PubMed ID: 31727855

Title: TTC5 mediates autoregulation of tubulin via mRNA degradation.

PubMed ID: 31727855

DOI: 10.1126/science.aaz4352

PubMed ID: 17563362

Title: Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.

PubMed ID: 17563362

DOI: 10.1073/pnas.0703876104

PubMed ID: 34996871

Title: Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.

PubMed ID: 34996871

DOI: 10.1073/pnas.2114994119

PubMed ID: 35482892

Title: Posttranslational modification of microtubules by the MATCAP detyrosinase.

PubMed ID: 35482892

DOI: 10.1126/science.abn6020

Sequence Information:

Length: 451
Mass: 50152
Checksum: 94355B4EC2086429
Sequence:

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK 
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD 
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRS IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TUBA1B

Associated with

Other Information

Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. PubMed ID: 6646120

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. PubMed ID: 8619814

Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. PubMed ID: 10339593

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. PubMed ID: 24906155

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Mitosis. Microtubule detyrosination guides chromosomes during mitosis. PubMed ID: 25908662

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

Dual chromatin and cytoskeletal remodeling by SETD2. PubMed ID: 27518565

Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. PubMed ID: 26972003

Vasohibins encode tubulin detyrosinating activity. PubMed ID: 29146869

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. PubMed ID: 32747782

TTC5 mediates autoregulation of tubulin via mRNA degradation. PubMed ID: 31727855

Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. PubMed ID: 17563362

Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules. PubMed ID: 34996871

Posttranslational modification of microtubules by the MATCAP detyrosinase. PubMed ID: 35482892