Details for: IRF9

Gene ID: 10379

Symbol: IRF9

Ensembl ID: ENSG00000213928

Description: interferon regulatory factor 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.58
    Marker Score: 1,822
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.82
    Marker Score: 1,103
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.43
    Marker Score: 1,409
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.27
    Marker Score: 11,175
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.27
    Marker Score: 449
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.2
    Marker Score: 5,888
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.18
    Marker Score: 709
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.02
    Marker Score: 2,866
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.01
    Marker Score: 732
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,717
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,940
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.98
    Marker Score: 1,063
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.94
    Marker Score: 214
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.93
    Marker Score: 1,341
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.93
    Marker Score: 2,556
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.92
    Marker Score: 780
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.91
    Marker Score: 299
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.91
    Marker Score: 888
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,707
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.88
    Marker Score: 594
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.86
    Marker Score: 277
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,896
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.85
    Marker Score: 1,764
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.84
    Marker Score: 1,237
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.82
    Marker Score: 294
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.81
    Marker Score: 2,069
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8
    Marker Score: 27,267
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.78
    Marker Score: 289
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.77
    Marker Score: 782
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.77
    Marker Score: 949
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,242
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.74
    Marker Score: 492
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 564
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.74
    Marker Score: 1,247
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.69
    Marker Score: 299
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.69
    Marker Score: 379
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.69
    Marker Score: 237
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,877
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.68
    Marker Score: 1,247
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.68
    Marker Score: 2,796
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.68
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.65
    Marker Score: 597
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.65
    Marker Score: 227
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.65
    Marker Score: 1,299
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.65
    Marker Score: 6,542
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.64
    Marker Score: 1,128
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.63
    Marker Score: 2,717
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.61
    Marker Score: 350
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.6
    Marker Score: 361
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.6
    Marker Score: 564
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.6
    Marker Score: 152
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.59
    Marker Score: 2,471
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.59
    Marker Score: 718
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.59
    Marker Score: 168
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.59
    Marker Score: 129
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.59
    Marker Score: 171
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.59
    Marker Score: 433
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.59
    Marker Score: 238
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.59
    Marker Score: 156
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.59
    Marker Score: 142
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.59
    Marker Score: 617
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.58
    Marker Score: 519
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.58
    Marker Score: 644
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.58
    Marker Score: 601
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.58
    Marker Score: 768
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.58
    Marker Score: 127
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.57
    Marker Score: 201
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.57
    Marker Score: 285
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.57
    Marker Score: 318
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.57
    Marker Score: 6,401
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.57
    Marker Score: 4,927
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.56
    Marker Score: 166
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.56
    Marker Score: 131
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.56
    Marker Score: 199
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.55
    Marker Score: 225
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.55
    Marker Score: 1,049
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.55
    Marker Score: 546
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.55
    Marker Score: 124
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 356
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 222
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.53
    Marker Score: 133
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.53
    Marker Score: 182
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.53
    Marker Score: 398
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.52
    Marker Score: 11,189
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.52
    Marker Score: 122
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.52
    Marker Score: 218
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.52
    Marker Score: 564
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.52
    Marker Score: 129
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.52
    Marker Score: 297
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.51
    Marker Score: 793

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** IRF9 acts as a transcriptional activator, binding to specific DNA sequences and recruiting co-activators to regulate the expression of ISGs. 2. **Interferon Signaling:** IRF9 is a critical component of the interferon signaling pathway, mediating the transcriptional responses to interferon-alpha (IFN-α), -beta (IFN-β), and -gamma (IFN-γ). 3. **Cell Type-Specific Expression:** IRF9 is expressed in a wide range of cell types, including immune cells, endothelial cells, and neural cells, highlighting its diverse roles in immune homeostasis and disease pathogenesis. 4. **Interactions with Other Proteins:** IRF9 interacts with various proteins, including interferons, interferon-stimulated genes, and other transcription factors, to regulate immune responses. **Pathways and Functions:** 1. **Interferon Signaling Pathway:** IRF9 mediates the transcriptional responses to IFN-α, -β, and -γ, regulating the expression of ISGs and contributing to antiviral, immunomodulatory, and anti-inflammatory effects. 2. **Immune Response:** IRF9 is essential for the regulation of immune responses, including the activation of immune cells, such as monocytes, dendritic cells, and T cells, and the production of cytokines and chemokines. 3. **Viral Infections:** IRF9 plays a critical role in the defense against viral infections, particularly in the context of IFN-α and IFN-β signaling. 4. **Inflammation and Immune Regulation:** IRF9 regulates immune responses and inflammation by modulating the expression of ISGs and influencing the activity of immune cells. **Clinical Significance:** Dysregulation of IRF9 has been implicated in various diseases, including: 1. **Viral Infections:** IRF9 deficiency or dysfunction has been associated with increased susceptibility to viral infections, such as hepatitis C and HIV. 2. **Autoimmune Diseases:** IRF9 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates immune responses and inflammation. 3. **Cancer:** IRF9 has been shown to have anti-tumor effects, and its dysregulation has been associated with cancer progression and metastasis. 4. **Neurological Disorders:** IRF9 has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it regulates immune responses and inflammation. In conclusion, IRF9 is a critical transcription factor that plays a vital role in regulating immune responses, particularly in the context of viral infections and inflammation. Its dysregulation has been implicated in various diseases, highlighting the importance of IRF9 in maintaining immune homeostasis and preventing disease pathogenesis.

Genular Protein ID: 856920352

Symbol: IRF9_HUMAN

Name: Interferon regulatory factor 9

UniProtKB Accession Codes:

Q00978 D3DS61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1630447

Title: Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

PubMed ID: 1630447

DOI: 10.1128/mcb.12.8.3315-3324.1992

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11846981

Title: Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation.

PubMed ID: 11846981

DOI: 10.1089/107999002753452719

PubMed ID: 10702714

Title: Viral inhibition of interferon signal transduction.

PubMed ID: 10702714

DOI: 10.1159/000053968

PubMed ID: 30143481

Title: Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.

PubMed ID: 30143481

DOI: 10.1084/jem.20180628

PubMed ID: 30826365

Title: Impaired control of multiple viral infections in a family with complete IRF9 deficiency.

PubMed ID: 30826365

DOI: 10.1016/j.jaci.2019.02.019

PubMed ID: 32699158

Title: Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

PubMed ID: 32699158

DOI: 10.4049/jimmunol.2000418

Sequence Information:

  • Length: 393
  • Mass: 43696
  • Checksum: F8E3784354BFD4A9
  • Sequence:
    • MASGRARCTR KLRNWVVEQV ESGQFPGVCW DDTAKTMFRI PWKHAGKQDF REDQDAAFFK 
AWAIFKGKYK EGDTGGPAVW KTRLRCALNK SSEFKEVPER GRMDVAEPYK VYQLLPPGIV 
SGQPGTQKVP SKRQHSSVSS ERKEEEDAMQ NCTLSPSVLQ DSLNNEEEGA SGGAVHSDIG 
SSSSSSSPEP QEVTDTTEAP FQGDQRSLEF LLPPEPDYSL LLTFIYNGRV VGEAQVQSLD 
CRLVAEPSGS ESSMEQVLFP KPGPLEPTQR LLSQLERGIL VASNPRGLFV QRLCPIPISW 
NAPQAPPGPG PHLLPSNECV ELFRTAYFCR DLVRYFQGLG PPPKFQVTLN FWEESHGSSH 
TPQNLITVKM EQAFARYLLE QTPEQQAAIL SLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.