TUBB3 | ENSG00000258947 | NCBI 10381

Details for: TUBB3

Gene ID: 10381

Symbol: TUBB3

Ensembl ID: ENSG00000258947

Description: tubulin beta 3 class III

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Autophagy
(R-HSA-9612973)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Axon guidance
(GO:0007411)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Metal ion binding
(GO:0046872)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Netrin-activated signaling pathway
(GO:0038007)
Netrin receptor binding
(GO:1990890)
Peptide binding
(GO:0042277)
Protein binding
(GO:0005515)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Tubulin beta-3 chain
Q53G92_HUMAN

Genular Protein ID: 3817487512

Symbol: TBB3_HUMAN

Name: Tubulin beta-3 chain

UniProtKB Accession Codes:

Q13509 A8K854 Q9BTZ0 Q9BW10

Database IDs:

Citations:

PubMed ID: 9473684

Title: Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents.

PubMed ID: 9473684

DOI: 10.1016/s0167-4781(97)00168-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14736079

Title: Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology.

PubMed ID: 14736079

DOI: 10.1177/088307380301801205

PubMed ID: 16371510

Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.

PubMed ID: 16371510

DOI: 10.1091/mbc.e05-07-0621

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 20074521

Title: Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.

PubMed ID: 20074521

DOI: 10.1016/j.cell.2009.12.011

PubMed ID: 20191564

Title: Tumoral and tissue-specific expression of the major human beta-tubulin isotypes.

PubMed ID: 20191564

DOI: 10.1002/cm.20436

PubMed ID: 24374158

Title: The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes.

PubMed ID: 24374158

DOI: 10.1016/j.ydbio.2013.12.025

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 28483977

Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

PubMed ID: 28483977

DOI: 10.1523/jneurosci.2617-16.2017

PubMed ID: 33894126

Title: Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.

PubMed ID: 33894126

DOI: 10.1016/j.ajhg.2021.04.004

PubMed ID: 34996871

Title: Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.

PubMed ID: 34996871

DOI: 10.1073/pnas.2114994119

PubMed ID: 35482892

Title: Posttranslational modification of microtubules by the MATCAP detyrosinase.

PubMed ID: 35482892

DOI: 10.1126/science.abn6020

PubMed ID: 20829227

Title: Mutations in the neuronal ss-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects.

PubMed ID: 20829227

DOI: 10.1093/hmg/ddq377

Sequence Information:

Length: 450
Mass: 50433
Checksum: 4B9CDE7DBA102949
Sequence:

MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPSGNYVGDS DLQLERISVY YNEASSHKYV 
PRAILVDLEP GTMDSVRSGA FGHLFRPDNF IFGQSGAGNN WAKGHYTEGA ELVDSVLDVV 
RKECENCDCL QGFQLTHSLG GGTGSGMGTL LISKVREEYP DRIMNTFSVV PSPKVSDTVV 
EPYNATLSIH QLVENTDETY CIDNEALYDI CFRTLKLATP TYGDLNHLVS ATMSGVTTSL 
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTARGSQQ YRALTVPELT QQMFDAKNMM 
AACDPRHGRY LTVATVFRGR MSMKEVDEQM LAIQSKNSSY FVEWIPNNVK VAVCDIPPRG 
LKMSSTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 
EYQQYQDATA EEEGEMYEDD EEESEAQGPK

Genular Protein ID: 2801093219

Symbol: Q53G92_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53G92

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

Length: 450
Mass: 50373
Checksum: F62A05101D0C5468
Sequence:

MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPSGNYVGDS DLQLERISVY YNEASSHKYV 
PRAILVDLEP GTMDSVRSGA FGHLFRPDNF IFGQSGAGNN WAKGHYTEGA ELVDSVLDVV 
RKECENCDCL QGFQLTHSLG GGTGSGMGTL LISKVREEYP DRIMNTFSVV PSPKVSDTVV 
EPYNATLSIH QLVENTDETY CIDNEALYDI CFRTLKLATP TYGDLNHLVS ATMSGVTTSL 
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTARGSQQ YRALTVPELT QQMFDAKNMM 
AACDPRHGRY LTVATVFRGR MSMKEVDEQM LAIQSKNSSC FVEWIPNNVK VAVCDIPPRG 
LKMSSTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 
EYQQYQDATA EEEGEMYEDD EEESEAQGPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TUBB3

Associated with

Other Information

Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents. PubMed ID: 9473684

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology. PubMed ID: 14736079

Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. PubMed ID: 16371510

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. PubMed ID: 20074521

Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. PubMed ID: 20191564

The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes. PubMed ID: 24374158

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. PubMed ID: 28483977

Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities. PubMed ID: 33894126

Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules. PubMed ID: 34996871

Posttranslational modification of microtubules by the MATCAP detyrosinase. PubMed ID: 35482892

Mutations in the neuronal ss-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects. PubMed ID: 20829227

Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. PubMed ID: 8125298

Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. PubMed ID: 9373149