TUBB4A | ENSG00000104833 | NCBI 10382

Details for: TUBB4A

Gene ID: 10382

Symbol: TUBB4A

Ensembl ID: ENSG00000104833

Description: tubulin beta 4A class IVa

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Calcium ion binding
(GO:0005509)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Negative regulation of microtubule polymerization
(GO:0031115)
Protein binding
(GO:0005515)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Tubulin beta-4A chain

Genular Protein ID: 899346783

Symbol: TBB4A_HUMAN

Name: Tubulin beta-4A chain

UniProtKB Accession Codes:

P04350 B3KQP4 Q969E5

Database IDs:

Citations:

PubMed ID: 6462917

Title: Sequence of an expressed human beta-tubulin gene containing ten Alu family members.

PubMed ID: 6462917

DOI: 10.1093/nar/12.14.5823

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8619814

Title: C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.

PubMed ID: 8619814

DOI: 10.1006/bbrc.1996.0211

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16371510

Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.

PubMed ID: 16371510

DOI: 10.1091/mbc.e05-07-0621

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 20191564

Title: Tumoral and tissue-specific expression of the major human beta-tubulin isotypes.

PubMed ID: 20191564

DOI: 10.1002/cm.20436

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 23582646

Title: A de novo mutation in the beta-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum.

PubMed ID: 23582646

DOI: 10.1016/j.ajhg.2013.03.018

PubMed ID: 23424103

Title: Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia.

PubMed ID: 23424103

DOI: 10.1002/ana.23832

Sequence Information:

Length: 444
Mass: 49586
Checksum: F7429D057C11A3F5
Sequence:

MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGNYV 
PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDAVLDVV 
RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVV PSPKVSDTVV 
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL 
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM 
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LSVQSKNSSY FVEWIPNNVK TAVCDIPPRG 
LKMAATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 
EYQQYQDATA EEGEFEEEAE EEVA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TUBB4A

Associated with

Other Information

Sequence of an expressed human beta-tubulin gene containing ten Alu family members. PubMed ID: 6462917

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. PubMed ID: 8619814

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. PubMed ID: 16371510

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. PubMed ID: 20191564

Initial characterization of the human central proteome. PubMed ID: 21269460

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

A de novo mutation in the beta-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum. PubMed ID: 23582646

Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia. PubMed ID: 23424103