Details for: SCML2

Gene ID: 10389

Symbol: SCML2

Ensembl ID: ENSG00000102098

Description: Scm polycomb group protein like 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.87
    Marker Score: 5,017
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.84
    Marker Score: 2,644
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,547
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.07
    Marker Score: 18,951
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,217
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.91
    Marker Score: 226
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.82
    Marker Score: 3,174
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.8
    Marker Score: 4,773
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.78
    Marker Score: 937
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,206
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,501
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.74
    Marker Score: 27,184
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.73
    Marker Score: 3,040
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.69
    Marker Score: 26,234
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.68
    Marker Score: 2,809
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.64
    Marker Score: 809
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.64
    Marker Score: 4,938
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.64
    Marker Score: 435
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.62
    Marker Score: 180
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.61
    Marker Score: 726
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9,506
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1,126
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.59
    Marker Score: 11,775
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.58
    Marker Score: 8,699
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.57
    Marker Score: 577
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 345
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.54
    Marker Score: 4,631
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.53
    Marker Score: 299
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32,655
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3,135
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.51
    Marker Score: 4,817
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.49
    Marker Score: 2,014
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.49
    Marker Score: 1,327
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.48
    Marker Score: 385
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.46
    Marker Score: 711
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.46
    Marker Score: 4,743
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.43
    Marker Score: 461
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.43
    Marker Score: 266
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.43
    Marker Score: 290
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4
    Marker Score: 169
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.35
    Marker Score: 232
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.35
    Marker Score: 3,280
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.34
    Marker Score: 233
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.34
    Marker Score: 1,576
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.3
    Marker Score: 105
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 190
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.28
    Marker Score: 344
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 653
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.28
    Marker Score: 387
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.27
    Marker Score: 134
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.27
    Marker Score: 230
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.27
    Marker Score: 286
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.26
    Marker Score: 400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.26
    Marker Score: 346
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.25
    Marker Score: 134
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.25
    Marker Score: 832
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.25
    Marker Score: 312
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.25
    Marker Score: 102
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.25
    Marker Score: 930
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.25
    Marker Score: 1,625
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.25
    Marker Score: 1,038
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.24
    Marker Score: 159
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.24
    Marker Score: 179
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.24
    Marker Score: 250
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.23
    Marker Score: 170
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.23
    Marker Score: 231
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.23
    Marker Score: 552
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.23
    Marker Score: 249
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 264
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.22
    Marker Score: 116
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.22
    Marker Score: 4,657
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.22
    Marker Score: 263
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 63

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCML2 is a PcG protein that interacts with histones and other chromatin-associated proteins to regulate chromatin structure and transcriptional activity. Its expression is tightly regulated during development, and alterations in SCML2 expression have been linked to various diseases, including cancer and neurodevelopmental disorders. The gene's involvement in cellular differentiation, proliferation, and survival underscores its importance in maintaining tissue homeostasis. **Pathways and Functions:** SCML2 is integrated into several key pathways, including: 1. **Anatomical structure morphogenesis**: SCML2 regulates the formation and patterning of tissues during development, influencing cell fate decisions and cellular differentiation. 2. **Chromatin binding**: SCML2 interacts with histones and other chromatin-associated proteins to modify chromatin structure and transcriptional activity. 3. **Negative regulation of DNA-templated transcription**: SCML2 acts as a transcriptional repressor, inhibiting the expression of specific genes involved in development and cellular differentiation. 4. **Protein binding**: SCML2 interacts with a range of proteins, including histones, transcription factors, and other PcG proteins, to regulate cellular processes. **Clinical Significance:** Dysregulation of SCML2 has been implicated in various diseases, including: 1. **Cancer**: Altered SCML2 expression has been linked to cancer development and progression, highlighting its potential as a therapeutic target. 2. **Neurodevelopmental disorders**: SCML2 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Immune response**: SCML2 plays a role in regulating immune cell function and response, making it a potential target for immunomodulatory therapies. In conclusion, SCML2 is a critical regulator of developmental processes and immune response, with implications for disease pathogenesis. Further research is necessary to fully elucidate the molecular mechanisms underlying SCML2's role in these processes and to explore its therapeutic potential.

Genular Protein ID: 1562983873

Symbol: SCML2_HUMAN

Name: Sex comb on midleg-like protein 2

UniProtKB Accession Codes:

Q9UQR0 Q5JXE6 Q86U98 Q8IWD0 Q8NDP2 Q9UGC5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10331946

Title: Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm): a new gene cluster on Xp22.

PubMed ID: 10331946

DOI: 10.1006/geno.1999.5755

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12952983

Title: Crystal structure of the malignant brain tumor (MBT) repeats in sex comb on midleg-like 2 (SCML2).

PubMed ID: 12952983

DOI: 10.1074/jbc.m306469200

Sequence Information:

  • Length: 700
  • Mass: 77257
  • Checksum: 05E086D4928DEE73
  • Sequence:
    • MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV 
NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT 
CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA 
IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP 
GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS 
VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY 
VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG 
EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH 
DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL 
SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF 
QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI 
DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.