Details for: CDR2

Gene ID: 1039

Symbol: CDR2

Ensembl ID: ENSG00000140743

Description: cerebellar degeneration related protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.9214
    Cell Significance Index: -33.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.2974
    Cell Significance Index: -33.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.9003
    Cell Significance Index: -34.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.6049
    Cell Significance Index: -29.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.5679
    Cell Significance Index: -33.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3778
    Cell Significance Index: -27.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2254
    Cell Significance Index: -32.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.8553
    Cell Significance Index: -30.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6796
    Cell Significance Index: -34.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.7011
    Cell Significance Index: 163.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.6314
    Cell Significance Index: 137.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3323
    Cell Significance Index: 65.1800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.2982
    Cell Significance Index: 20.4000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2092
    Cell Significance Index: 36.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1599
    Cell Significance Index: 136.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9608
    Cell Significance Index: 389.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9532
    Cell Significance Index: 38.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8757
    Cell Significance Index: 672.7700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6847
    Cell Significance Index: 17.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5146
    Cell Significance Index: 43.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3806
    Cell Significance Index: 105.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2314
    Cell Significance Index: 17.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2278
    Cell Significance Index: 26.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1631
    Cell Significance Index: 28.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8306
    Cell Significance Index: 749.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8172
    Cell Significance Index: 11.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6665
    Cell Significance Index: 16.6600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.6645
    Cell Significance Index: 4.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6468
    Cell Significance Index: 7.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5688
    Cell Significance Index: 25.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5450
    Cell Significance Index: 33.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5441
    Cell Significance Index: 59.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5367
    Cell Significance Index: 96.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5212
    Cell Significance Index: 84.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5167
    Cell Significance Index: 31.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4844
    Cell Significance Index: 59.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4080
    Cell Significance Index: 14.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3991
    Cell Significance Index: 20.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3715
    Cell Significance Index: 699.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3516
    Cell Significance Index: 70.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2876
    Cell Significance Index: 7.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2324
    Cell Significance Index: 16.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2308
    Cell Significance Index: 5.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2214
    Cell Significance Index: 3.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2188
    Cell Significance Index: 4.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1929
    Cell Significance Index: 122.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1893
    Cell Significance Index: 10.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1867
    Cell Significance Index: 3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1708
    Cell Significance Index: 77.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1579
    Cell Significance Index: 30.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1291
    Cell Significance Index: 238.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1281
    Cell Significance Index: 1.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1087
    Cell Significance Index: 167.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0888
    Cell Significance Index: 8.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0404
    Cell Significance Index: 22.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0297
    Cell Significance Index: 40.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0279
    Cell Significance Index: 4.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0103
    Cell Significance Index: 0.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0022
    Cell Significance Index: -1.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0044
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0075
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0082
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -14.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0202
    Cell Significance Index: -2.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0232
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0267
    Cell Significance Index: -16.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0339
    Cell Significance Index: -2.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0368
    Cell Significance Index: -26.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0432
    Cell Significance Index: -32.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0544
    Cell Significance Index: -1.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0690
    Cell Significance Index: -1.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0703
    Cell Significance Index: -3.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0760
    Cell Significance Index: -21.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0790
    Cell Significance Index: -16.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1283
    Cell Significance Index: -15.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1338
    Cell Significance Index: -17.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1346
    Cell Significance Index: -13.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1465
    Cell Significance Index: -6.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1606
    Cell Significance Index: -16.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1708
    Cell Significance Index: -19.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1779
    Cell Significance Index: -22.9800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1791
    Cell Significance Index: -2.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2145
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2168
    Cell Significance Index: -24.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2655
    Cell Significance Index: -16.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2754
    Cell Significance Index: -7.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2781
    Cell Significance Index: -17.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2846
    Cell Significance Index: -7.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2970
    Cell Significance Index: -15.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3524
    Cell Significance Index: -24.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3678
    Cell Significance Index: -11.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3845
    Cell Significance Index: -30.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4363
    Cell Significance Index: -6.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4413
    Cell Significance Index: -6.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4718
    Cell Significance Index: -7.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4949
    Cell Significance Index: -13.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4968
    Cell Significance Index: -25.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5026
    Cell Significance Index: -26.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5153
    Cell Significance Index: -34.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CDR2 is significantly expressed in various cell types, including sncg GABAergic cortical interneuron, lamp5 GABAergic cortical interneuron, pigmented epithelial cell, and corneal epithelial cell, highlighting its broad tissue distribution. 2. **Protein Binding:** The CDR2 protein exhibits protein binding properties, which may play a crucial role in its function and interactions within the cell. 3. **Pathway Association:** CDR2 is associated with various pathways, including Cytoplasm, Molecular_function, and Protein binding, underscoring its involvement in multiple cellular processes. **Pathways and Functions:** 1. **GABAergic Interneuron Function:** CDR2 is specifically expressed in GABAergic cortical interneurons, which are crucial for regulating neuronal activity and synaptic transmission. The protein's presence in these cells suggests a potential role in modulating GABAergic neurotransmission. 2. **Cerebellar Degeneration:** The association of CDR2 with cerebellar degeneration implies that the protein may play a role in the pathogenesis of this condition. Further research is necessary to elucidate the mechanisms underlying this relationship. 3. **Cellular Signaling:** The protein binding properties of CDR2 may facilitate its interaction with other proteins, influencing cellular signaling pathways and potentially contributing to its functional roles. **Clinical Significance:** 1. **Cerebellar Degeneration:** The discovery of CDR2's association with cerebellar degeneration has significant clinical implications, as it may provide a novel therapeutic target for the treatment of this condition. 2. **Neurological Disorders:** The expression of CDR2 in GABAergic cortical interneurons highlights its potential involvement in neurological disorders, such as epilepsy and Parkinson's disease, which are characterized by dysregulation of GABAergic neurotransmission. 3. **Cancer Research:** The presence of CDR2 in corneal epithelial cells and pigmented epithelial cells suggests that the protein may play a role in cancer development and progression, particularly in tissues with high epithelial cell turnover. In conclusion, the CDR2 gene is a complex protein with multiple roles in various cellular processes. Further research is necessary to fully elucidate its functional significance and to explore its potential therapeutic applications in cerebellar degeneration and neurological disorders.

Genular Protein ID: 4112396372

Symbol: CDR2_HUMAN

Name: Cerebellar degeneration-related protein 2

UniProtKB Accession Codes:

Q01850 A8K8A8 Q13977

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GeneWiki 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2014264

Title: Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration.

PubMed ID: 2014264

DOI: 10.1073/pnas.88.8.3451

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2260856

Title: Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration.

PubMed ID: 2260856

DOI: 10.1002/ana.410280515

PubMed ID: 1763903

Title:

PubMed ID: 1763903

DOI: 10.1002/ana.410300523

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 454
  • Mass: 51855
  • Checksum: A7615F2C5AE08D2C
  • Sequence:
    • MLAENLVEEF EMKEDEPWYD HQDLQQDLQL AAELGKTLLD RNTELEDSVQ QMYTTNQEQL 
QEIEYLTKQV ELLRQMNEQH AKVYEQLDVT ARELEETNQK LVADSKASQQ KILSLTETIE 
CLQTNIDHLQ SQVEELKSSG QGRRSPGKCD QEKPAPSFAC LKELYDLRQH FVYDHVFAEK 
ITSLQGQPSP DEEENEHLKK TVTMLQAQLS LERQKRVTME EEYGLVLKEN SELEQQLGAT 
GAYRARALEL EAEVAEMRQM LQSEHPFVNG VEKLVPDSLY VPFKEPSQSL LEEMFLTVPE 
SHRKPLKRSS SETILSSLAG SDIVKGHEET CIRRAKAVKQ RGISLLHEVD TQYSALKVKY 
EELLKKCQEE QDSLSHKAVQ TSRAAAKDLT GVNAQSEPVA SGWELASVNP EPVSSPTTPP 
EYKALFKEIF SCIKKTKQEI DEQRTKYRSL SSHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.