Details for: CEPT1

Gene ID: 10390

Symbol: CEPT1

Ensembl ID: ENSG00000134255

Description: choline/ethanolamine phosphotransferase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5
    Marker Score: 2,622
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.5
    Marker Score: 6,107
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.46
    Marker Score: 1,172
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,931
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11,528
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.34
    Marker Score: 82,191
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.33
    Marker Score: 2,318
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.29
    Marker Score: 4,983
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12,204
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.24
    Marker Score: 45,726
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.23
    Marker Score: 46,756
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.23
    Marker Score: 5,104
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.23
    Marker Score: 11,558
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.22
    Marker Score: 18,284
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.2
    Marker Score: 1,854
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2
    Marker Score: 351
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.16
    Marker Score: 649
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.15
    Marker Score: 22,799
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.13
    Marker Score: 2,487
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.11
    Marker Score: 11,508
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.11
    Marker Score: 8,474
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.03
    Marker Score: 1,032
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.03
    Marker Score: 6,603
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.02
    Marker Score: 1,010
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.02
    Marker Score: 909
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.02
    Marker Score: 1,123
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,677
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1
    Marker Score: 1,202
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,901
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.99
    Marker Score: 494
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Marker Score: 21,191
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.99
    Marker Score: 481
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.92
    Marker Score: 1,063
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.92
    Marker Score: 3,950
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.91
    Marker Score: 319
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.89
    Marker Score: 673
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.88
    Marker Score: 954
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.88
    Marker Score: 403
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,010
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.87
    Marker Score: 459
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.87
    Marker Score: 938
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.86
    Marker Score: 849
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,392
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.83
    Marker Score: 1,515
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.83
    Marker Score: 1,473
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.82
    Marker Score: 480
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.82
    Marker Score: 295
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.81
    Marker Score: 339
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.79
    Marker Score: 1,064
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.79
    Marker Score: 2,799
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.78
    Marker Score: 17,448
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1,839
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.78
    Marker Score: 3,063
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.78
    Marker Score: 715
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.77
    Marker Score: 5,020
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.77
    Marker Score: 187
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.76
    Marker Score: 307
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.76
    Marker Score: 460
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.76
    Marker Score: 4,061
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.75
    Marker Score: 2,223
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 370
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.74
    Marker Score: 3,095
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.73
    Marker Score: 271
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.73
    Marker Score: 906
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.73
    Marker Score: 272
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.73
    Marker Score: 546
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.73
    Marker Score: 6,259
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.72
    Marker Score: 265
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.72
    Marker Score: 875
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11,310
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.72
    Marker Score: 732
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.72
    Marker Score: 3,332
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.72
    Marker Score: 624
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.72
    Marker Score: 1,384
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.72
    Marker Score: 1,713
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.72
    Marker Score: 1,946
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.72
    Marker Score: 427
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.71
    Marker Score: 858
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.71
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,985
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.71
    Marker Score: 442
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.71
    Marker Score: 163
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.71
    Marker Score: 264
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.71
    Marker Score: 885
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.7
    Marker Score: 244
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7
    Marker Score: 7,063
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.7
    Marker Score: 420
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.69
    Marker Score: 743
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.69
    Marker Score: 244
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.69
    Marker Score: 12,238

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEPT1 is a member of the phosphotransferase family, which catalyzes the transfer of phosphate groups between molecules. Specifically, CEPT1 is responsible for the transfer of choline to diacylglycerol (DAG) or phosphatidylcholine (PC), resulting in the formation of phosphatidylethanolamine (PE). This reaction is a critical step in the synthesis of PE, a phospholipid that plays a vital role in cell membrane structure and function. **Pathways and Functions:** CEPT1 is involved in several key pathways, including: 1. **Cdp-choline pathway:** CEPT1 is a key enzyme in this pathway, which is responsible for the conversion of CDP-choline to phosphatidylethanolamine (PE). 2. **Glycerophospholipid biosynthesis:** CEPT1 is involved in the synthesis of PE, a critical component of cell membranes. 3. **Lipid metabolic process:** CEPT1 plays a role in the regulation of lipid metabolism, including the breakdown and synthesis of phospholipids. 4. **Synthesis of PC and PE:** CEPT1 is responsible for the transfer of choline to PC and PE, resulting in the formation of these phospholipids. **Clinical Significance:** CEPT1 has been implicated in various diseases and disorders, including: 1. **Neurological disorders:** CEPT1 has been shown to play a role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** CEPT1 has been implicated in the development and progression of certain types of cancer, including breast cancer and lung cancer. 3. **Immune system dysfunction:** CEPT1 has been shown to play a role in the regulation of immune cell function, including the development and function of B cells and T cells. 4. **Cardiovascular disease:** CEPT1 has been implicated in the development of cardiovascular disease, including atherosclerosis and hypertension. In conclusion, CEPT1 is a critical gene that plays a pivotal role in lipid metabolism. Its involvement in various pathways and its clinical significance highlight the importance of further research into the functions and dysregulation of CEPT1. As an expert immunologist, I believe that a deeper understanding of CEPT1 will provide valuable insights into the development of new therapeutic strategies for various diseases and disorders.

Genular Protein ID: 1505990906

Symbol: CEPT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6K0 Q69YJ9 Q9P0Y8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 85 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 4 EMBL 6 EMDB 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 30 SABIO-RK 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10191259

Title: Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine.

PubMed ID: 10191259

DOI: 10.1042/bj3390291

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10893425

Title: Cloning, genomic organization, and characterization of a human cholinephosphotransferase.

PubMed ID: 10893425

DOI: 10.1074/jbc.m005786200

PubMed ID: 12216837

Title: PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).

PubMed ID: 12216837

DOI: 10.1007/s11745-002-0947-6

PubMed ID: 12221122

Title: The major sites of cellular phospholipid synthesis and molecular determinants of fatty acid and lipid head group specificity.

PubMed ID: 12221122

DOI: 10.1091/mbc.01-11-0540

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 416
  • Mass: 46554
  • Checksum: A25FED1193342FD9
  • Sequence:
    • MSGHRSTRKR CGDSHPESPV GFGHMSTTGC VLNKLFQLPT PPLSRHQLKR LEEHRYQSAG 
RSLLEPLMQG YWEWLVRRVP SWIAPNLITI IGLSINICTT ILLVFYCPTA TEQAPLWAYI 
ACACGLFIYQ SLDAIDGKQA RRTNSSSPLG ELFDHGCDSL STVFVVLGTC IAVQLGTNPD 
WMFFCCFAGT FMFYCAHWQT YVSGTLRFGI IDVTEVQIFI IIMHLLAVIG GPPFWQSMIP 
VLNIQMKIFP ALCTVAGTIF SCTNYFRVIF TGGVGKNGST IAGTSVLSPF LHIGSVITLA 
AMIYKKSAVQ LFEKHPCLYI LTFGFVSAKI TNKLVVAHMT KSEMHLHDTA FIGPALLFLD 
QYFNSFIDEY IVLWIALVFS FFDLIRYCVS VCNQIASHLH IHVFRIKVST AHSNHH

Genular Protein ID: 3628509232

Symbol: A0A8V8TRF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TRF3

Database IDs:

ARBA 38 CTD 1 ChEBI 77 EC 4 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 1 Rhea 30 RuleBase 1 SAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 416
  • Mass: 46642
  • Checksum: B5AA1043B327A785
  • Sequence:
    • MSGHRSTRKR CGDSHPESPV GFGHMSTTGC VLNKLFQLPT PPLSRHQLKR LEEHRYQSAG 
RSLLEPLMQG YWEWLVRRVP SWIAPNLITI IGLSINICTT ILLVFYCPTA TEQAPLWAYI 
ACACGLFIYQ SLDAIDGKQA RRTNSSSPLG ELFDHGCDSL STVFVVLGTC IAVQLGTNPD 
WMFFCCFAGT FMFYCAHWQT YVSGTLRFGI FDVTESQIII IICQLLTGTL GPWFWNFTIP 
VLNIQMKIFP ALCTVAGTIF SCTNYFRVIF TGGVGKNGST IAGTSVLSPF LHIGSVITLA 
AMIYKKSAVQ LFEKHPCLYI LTFGFVSAKI TNKLVVAHMT KSEMHLHDTA FIGPALLFLD 
QYFNSFIDEY IVLWIALVFS FFDLIRYCVS VCNQIASHLH IHVFRIKVST AHSNHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.