ANAPC10 | ENSG00000164162 | NCBI 10393

Details for: ANAPC10

Gene ID: 10393

Symbol: ANAPC10

Ensembl ID: ENSG00000164162

Description: anaphase promoting complex subunit 10

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Protein k11-linked ubiquitination
(GO:0070979)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)

Other Information

Proteins

Anaphase-promoting complex subunit 10

Genular Protein ID: 837339843

Symbol: APC10_HUMAN

Name: Anaphase-promoting complex subunit 10

UniProtKB Accession Codes:

Q9UM13 D3DNZ7 Q2V500 Q9UG51 Q9Y5R0

Database IDs:

Citations:

PubMed ID: 10318877

Title: Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.

PubMed ID: 10318877

DOI: 10.1074/jbc.274.20.14500

PubMed ID: 10498862

Title: Identification of human APC10/Doc1 as a subunit of anaphase promoting complex.

PubMed ID: 10498862

DOI: 10.1038/sj.onc.1203133

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11524682

Title: Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.

PubMed ID: 11524682

DOI: 10.1038/nsb0901-784

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

PubMed ID: 34595750

Title: A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

PubMed ID: 34595750

DOI: 10.1111/cge.14069

Sequence Information:

Length: 185
Mass: 21252
Checksum: ACA7F245B3861FF5
Sequence:

MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ 
PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI 
HVPLTDNHKK PTRTFMIQIA VLANHQNGRD THMRQIKIYT PVEESSIGKF PRCTTIDFMM 
YRSIR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANAPC10

Associated with

Other Information

Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. PubMed ID: 10318877

Identification of human APC10/Doc1 as a subunit of anaphase promoting complex. PubMed ID: 10498862

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. PubMed ID: 11524682

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744

A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. PubMed ID: 34595750