Details for: PRG3

Gene ID: 10394

Symbol: PRG3

Ensembl ID: ENSG00000156575

Description: proteoglycan 3, pro eosinophil major basic protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.96
    Marker Score: 4,082
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1,522
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.73
    Marker Score: 914
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.13
    Marker Score: 662
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.13
    Marker Score: 624
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.02
    Marker Score: 1,320
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.01
    Marker Score: 421
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.99
    Marker Score: 755
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,355
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1,499
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.83
    Marker Score: 530
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.82
    Marker Score: 2,393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 510
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.72
    Marker Score: 184
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 535
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.59
    Marker Score: 562
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.55
    Marker Score: 713
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.49
    Marker Score: 281
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.4
    Marker Score: 242
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.35
    Marker Score: 2,956
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 658
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 212
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.17
    Marker Score: 347
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 317
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.11
    Marker Score: 1,720
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 597
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 122
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 274
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.03
    Marker Score: 55
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 73
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 61
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 38
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 27
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 27
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0
    Marker Score: 26

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PRG3 is a proteoglycan that exhibits a unique structure, consisting of a core protein linked to a GAG chain. The core protein is composed of three domains: the N-terminal domain, the C-terminal domain, and the central domain. The GAG chain is composed of repeating units of galactose and glucuronic acid. PRG3 is also known as pro-eosinophil major basic protein 2 due to its association with eosinophil granules and its role in eosinophil activation. **Pathways and Functions** PRG3 is involved in various biological pathways, including: 1. **Immune Response**: PRG3 plays a crucial role in the regulation of immune responses, particularly in the activation of eosinophils and the modulation of inflammation. 2. **Extracellular Matrix Maintenance**: PRG3 is involved in the maintenance of the extracellular matrix, particularly in the regulation of collagen synthesis and degradation. 3. **Cell Signaling**: PRG3 interacts with various signaling molecules, including growth factors and cytokines, to regulate cell growth, differentiation, and survival. 4. **Innate Immunity**: PRG3 is expressed in the innate immune system, where it plays a role in the recognition and elimination of pathogens. PRG3 functions as a chemoattractant, a chemokine, and a cytokine, influencing the behavior of various immune cells, including eosinophils, neutrophils, and dendritic cells. It also regulates the expression of other genes involved in immune responses, including those involved in inflammation and tissue repair. **Clinical Significance** Dysregulation of PRG3 has been implicated in various diseases, including: 1. **Allergic Disorders**: PRG3 is involved in the regulation of eosinophil activation and the production of pro-inflammatory cytokines, making it a potential target for the treatment of allergic disorders. 2. **Autoimmune Disorders**: PRG3 dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus, where it may contribute to tissue damage and inflammation. 3. **Cancer**: PRG3 has been shown to promote tumor growth and metastasis, suggesting its potential role as a cancer biomarker and therapeutic target. 4. **Neurological Disorders**: PRG3 has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it may contribute to inflammation and tissue damage. In conclusion, PRG3 is a multifunctional protein that plays a crucial role in various biological processes, including immune responses, extracellular matrix maintenance, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms and therapeutic potential of PRG3.

Genular Protein ID: 541442459

Symbol: PRG3_HUMAN

Name: Proteoglycan 3

UniProtKB Accession Codes:

Q9Y2Y8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10318872

Title: A novel and highly divergent homolog of human eosinophil granule major basic protein.

PubMed ID: 10318872

DOI: 10.1074/jbc.274.20.14464

PubMed ID: 11170744

Title: Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes.

PubMed ID: 11170744

DOI: 10.1006/geno.2000.6391

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 225
  • Mass: 25406
  • Checksum: AA073254496F9624
  • Sequence:
    • MQCLLLLPFL LLGTVSALHL ENDAPHLESL ETQADLGQDL DSSKEQERDL ALTEEVIQAE 
GEEVKASACQ DNFEDEEAME SDPAALDKDF QCPREEDIVE VQGSPRCKIC RYLLVRTPKT 
FAEAQNVCSR CYGGNLVSIH DFNFNYRIQC CTSTVNQAQV WIGGNLRGWF LWKRFCWTDG 
SHWNFAYWSP GQPGNGQGSC VALCTKGGYW RRAQCDKQLP FVCSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.