Details for: DLC1
Associated with
Other Information
Genular Protein ID: 3548394199
Symbol: RHG07_HUMAN
Name: Rho GTPase-activating protein 7
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9605766
Title: Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
PubMed ID: 9605766
PubMed ID: 11214970
Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 11214970
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21217778
Title: A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.
PubMed ID: 21217778
DOI: 10.1038/onc.2010.576
PubMed ID: 17190795
Title: The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1.
PubMed ID: 17190795
PubMed ID: 18786931
Title: Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration.
PubMed ID: 18786931
PubMed ID: 19170769
Title: Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology.
PubMed ID: 19170769
PubMed ID: 19826001
Title: Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.
PubMed ID: 19826001
PubMed ID: 19710422
Title: DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain.
PubMed ID: 19710422
PubMed ID: 20798394
Title: Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.
PubMed ID: 20798394
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26427649
Title: Tensin1 positively regulates RhoA activity through its interaction with DLC1.
PubMed ID: 26427649
PubMed ID: 26166433
Title: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.
PubMed ID: 26166433
DOI: 10.1038/ncomms8721
PubMed ID: 19317456
Title: Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.
PubMed ID: 19317456
DOI: 10.1021/bi9000936
PubMed ID: 19158340
Title: The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.
PubMed ID: 19158340
DOI: 10.1242/jcs.027482
PubMed ID: 10649492
Title: Sequence variants of DLC1 in colorectal and ovarian tumours.
PubMed ID: 10649492
DOI: 10.1002/(sici)1098-1004(200002)15:2<156::aid-humu4>3.0.co;2-4
Sequence Information:
- Length: 1528
- Mass: 170591
- Checksum: 5D20F29CC606302E
- Sequence:
MSVAIRKRSW EEHVTHWMGQ PFNSDDRNTA CHHGLVADSL QASMEKDATL NVDRKEKCVS LPDCCHGSEL RDFPGRPMGH LSKDVDENDS HEGEDQFLSL EASTETLVHV SDEDNNADLC LTDDKQVLNT QGQKTSGQHM IQGAGSLEKA LPIIQSNQVS SNSWGIAGET ELALVKESGE RKVTDSISKS LELCNEISLS EIKDAPKVNA VDTLNVKDIA PEKQLLNSAV IAQQRRKPDP PKDENERSTC NVVQNEFLDT PCTNRGLPLL KTDFGSCLLQ PPSCPNGMSA ENGLEKSGFS QHQNKSPPKV KAEDGMQCLQ LKETLATQEP TDNQVRLRKR KEIREDRDRA RLDSMVLLIM KLDQLDQDIE NALSTSSSPS GTPTNLRRHV PDLESGSESG ADTISVNQTR VNLSSDTEST DLPSSTPVAN SGTKPKTTAI QGISEKEKAE IEAKEACDWL RATGFPQYAQ LYEDFLFPID ISLVKREHDF LDRDAIEALC RRLNTLNKCA VMKLEISPHR KRSDDSDEDE PCAISGKWTF QRDSKRWSRL EEFDVFSPKQ DLVPGSPDDS HPKDGPSPGG TLMDLSERQE VSSVRSLSST GSLPSHAPPS EDAATPRTNS VISVCSSSNL AGNDDSFGSL PSPKELSSFS FSMKGHEKTA KSKTRSLLKR MESLKLKSSH HSKHKAPSKL GLIISGPILQ EGMDEEKLKQ LNCVEISALN GNRINVPMVR KRSVSNSTQT SSSSSQSETS SAVSTPSPVT RTRSLSACNK RVGMYLEGFD PFNQSTFNNV VEQNFKNRES YPEDTVFYIP EDHKPGTFPK ALTNGSFSPS GNNGSVNWRT GSFHGPGHIS LRRENSSDSP KELKRRNSSS SMSSRLSIYD NVPGSILYSS SGDLADLENE DIFPELDDIL YHVKGMQRIV NQWSEKFSDE GDSDSALDSV SPCPSSPKQI HLDVDNDRTT PSDLDSTGNS LNEPEEPSEI PERRDSGVGA SLTRSNRHRL RWHSFQSSHR PSLNSVSLQI NCQSVAQMNL LQKYSLLKLT ALLEKYTPSN KHGFSWAVPK FMKRIKVPDY KDRSVFGVPL TVNVQRTGQP LPQSIQQAMR YLRNHCLDQV GLFRKSGVKS RIQALRQMNE GAIDCVNYEG QSAYDVADML KQYFRDLPEP LMTNKLSETF LQIYQYVPKD QRLQAIKAAI MLLPDENREV LQTLLYFLSD VTAAVKENQM TPTNLAVCLA PSLFHLNTLK RENSSPRVMQ RKQSLGKPDQ KDLNENLAAT QGLAHMIAEC KKLFQVPEEM SRCRNSYTEQ ELKPLTLEAL GHLGNDDSAD YQHFLQDCVD GLFKEVKEKF KGWVSYSTSE QAELSYKKVS EGPPLRLWRS VIEVPAVPEE ILKRLLKEQH LWDVDLLDSK VIEILDSQTE IYQYVQNSMA PHPARDYVVL RTWRTNLPKG ACALLLTSVD HDRAPVVGVR VNVLLSRYLI EPCGPGKSKL TYMCRVDLRG HMPEWYTKSF GHLCAAEVVK IRDSFSNQNT ETKDTKSR
Genular Protein ID: 865060207
Symbol: A8K119_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1091
- Mass: 122825
- Checksum: 359F3BB4B950A417
- Sequence:
MCRKKPDTMI LTQIEAKEAC DWLRATGFPQ YAQLYEDFLF PIDISLVKRE HDFLDRDAIE ALCRRLNTLN KCAVMKLEIS PHRKRSDDSD EDEPCAISGK WTFQRDSKRW SRLEEFDVFS PKQDLVPGSP DDSHPKDGPS PGGTLMDLSE RQEVSSVRSL SSTGSLPSHA PPSEDAATPR TNSVISVCSS SNLAGNDDSF GSLPSPKELS SFSFSMKGHE KTAKSKTRSL LKRMESLKLK SSHHSKHKAP SKLGLIISGP ILQEGMDEEK LKQLNCVEIS ALNGNRINVP MVRKRSVSNS TQTSSSSSQS EASSAVSTPS PVTRTRSLSA CNKRVGMYLE GFDPFNQSTF NNVVEQNFKN RESYPEDTVF YIPEDHKPGT FPKALTNGSF SPSGNNGSVN WRTGSFHGPG HISLRRENSS DSPKELKRRN SSSSMSSRLS IYDNVPGSIL YSSSGDLADL ENEDIFPELD DILYHVKGMQ RIVNQWSEKF SDEGDSDSAL DSVSPCPSSP KQIHLDVDND RTTPSDLDST GNSLNEPEEP SEIPERRDSG VGASLTRSNR HRLRWHSFQS SHRPSLNSVS LQINCQSVAQ MNLLQKYSLL KLTALLEKYT PSNKHGFSWA VPKFMKRIKV PDYKDRSVFG VPLTVNVQRT GQPLPQSIQQ AMRYLRNHCL DQVGLFRKSG VKSRIQALRQ MNEGAIDCVN YEGQSAYDVA DMLKQYFRDL PEPLMTNKLS ETFLQIYQYV PKDQRLQAIK AAIMLLPDEN REVLQTLLYF LSDVTAAVKE NQMTPTNLAV CLAPSLFHLN TLRRENSSPR VMQRKQSLGK PDQKDLNENL AATQGLAHMI AECKKLFQVP EEMSRCRNSY TEQELKPLTL EALGHLGNDD SADYQHFLQD CVDGLFKEVK EKFKGWVSYS TSEQAELSYK KVSEGPPLRL WRSVIEVPAV PEEILKRLLK EQHLWDVDLL DSKVIEILDS QTEIYQYVQN SMAPHPARDY VVLRTWRTNL PKGACALLLT SVDHDRAPVV GVRVNVLLSR YLIEPCGPGK SKLTYMCRVD LRGHMPEWYT KSFGHLCAAE VVKIRDSFSN QNTETKDTKS R
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.