Details for: DLC1

Gene ID: 10395

Symbol: DLC1

Ensembl ID: ENSG00000164741

Description: DLC1 Rho GTPase activating protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 10.29
    Marker Score: 14,477
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.82
    Marker Score: 174,381
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 7.51
    Marker Score: 4,070
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 6.94
    Marker Score: 2,293
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 6.57
    Marker Score: 8,189
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.96
    Marker Score: 19,512
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.17
    Marker Score: 21,550
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.34
    Marker Score: 2,414
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 4.09
    Marker Score: 2,694
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.07
    Marker Score: 2,676
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4
    Marker Score: 89,443
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.96
    Marker Score: 1,450
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.94
    Marker Score: 8,642
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.89
    Marker Score: 3,708
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.73
    Marker Score: 31,570
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.44
    Marker Score: 3,961
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.31
    Marker Score: 53,196
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.02
    Marker Score: 5,818
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.96
    Marker Score: 1,656
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.9
    Marker Score: 6,942
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.77
    Marker Score: 4,027
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.56
    Marker Score: 3,081
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.53
    Marker Score: 16,480
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.46
    Marker Score: 52,521
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.42
    Marker Score: 2,591
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.41
    Marker Score: 910
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.36
    Marker Score: 20,677
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.27
    Marker Score: 950
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.22
    Marker Score: 7,876
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.21
    Marker Score: 9,165
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,568
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.16
    Marker Score: 79,515
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.15
    Marker Score: 674
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.15
    Marker Score: 558
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.14
    Marker Score: 1,212
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.1
    Marker Score: 1,251
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.95
    Marker Score: 66,481
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.92
    Marker Score: 19,870
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18,242
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.9
    Marker Score: 919
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.88
    Marker Score: 71,535
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,977
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.8
    Marker Score: 493
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.78
    Marker Score: 1,461
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.78
    Marker Score: 11,561
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.74
    Marker Score: 4,435
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.74
    Marker Score: 1,506
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.71
    Marker Score: 2,754
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.71
    Marker Score: 767
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.7
    Marker Score: 2,107
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.66
    Marker Score: 822
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.65
    Marker Score: 6,376
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.64
    Marker Score: 1,467
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.63
    Marker Score: 21,741
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.61
    Marker Score: 3,282
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2,488
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.59
    Marker Score: 31,677
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.56
    Marker Score: 2,648
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.55
    Marker Score: 1,103
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.55
    Marker Score: 408
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.51
    Marker Score: 11,537
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.49
    Marker Score: 9,581
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.47
    Marker Score: 7,746
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.46
    Marker Score: 7,827
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.45
    Marker Score: 2,903
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.43
    Marker Score: 395
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3,364
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.42
    Marker Score: 162,773
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.42
    Marker Score: 1,525
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.41
    Marker Score: 6,097
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.39
    Marker Score: 85,762
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.39
    Marker Score: 2,141
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.39
    Marker Score: 2,330
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.35
    Marker Score: 1,276
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20,988
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.32
    Marker Score: 1,196
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.3
    Marker Score: 1,607
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.29
    Marker Score: 1,382
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.29
    Marker Score: 3,376
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.29
    Marker Score: 365
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.28
    Marker Score: 5,223
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.28
    Marker Score: 745
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.27
    Marker Score: 671
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.25
    Marker Score: 300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 740
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.23
    Marker Score: 700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.21
    Marker Score: 279
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.2
    Marker Score: 1,029
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.19
    Marker Score: 361
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.18
    Marker Score: 275
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.15
    Marker Score: 252
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.14
    Marker Score: 1,943
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.11
    Marker Score: 1,198
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.1
    Marker Score: 2,305
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1
    Marker Score: 6,619
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.07
    Marker Score: 1,010
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.06
    Marker Score: 390
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.05
    Marker Score: 502
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.05
    Marker Score: 278
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,716

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DLC1 is a member of the RhoGAP family, which consists of proteins that regulate the activity of Rho GTPases. DLC1 is characterized by its ability to inhibit the activity of Rho GTPases, such as RhoA, Rac1, and Cdc42, by accelerating the hydrolysis of GTP to GDP. This inhibitory effect is mediated by its SH3 domain, which binds to the GTPase-binding domain of Rho GTPases. DLC1's expression is tightly regulated by various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. **Pathways and Functions** DLC1's regulatory function is mediated through its interaction with Rho GTPases and other signaling molecules. Some of the key pathways and functions of DLC1 include: 1. **Actin Cytoskeleton Organization**: DLC1 regulates the actin cytoskeleton organization by inhibiting the activity of Rho GTPases, which are involved in the formation of stress fibers and focal adhesions. 2. **Apoptosis**: DLC1's interaction with Bcl-2 family proteins regulates the execution phase of apoptosis, promoting cell death. 3. **Cell Migration**: DLC1's inhibitory effect on Rho GTPases regulates cell migration by modulating the formation of stress fibers and focal adhesions. 4. **Cell Shape Regulation**: DLC1's interaction with the actin cytoskeleton regulates cell shape by modulating the formation of stress fibers and focal adhesions. 5. **Signaling by Rho GTPases**: DLC1's regulatory function is also involved in signaling by Rho GTPases, including the regulation of small GTPase-mediated signal transduction. **Clinical Significance** DLC1's dysregulation has been implicated in various diseases, including: 1. **Cancer**: DLC1's loss or downregulation has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders**: DLC1's dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease**: DLC1's regulatory function is also involved in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In conclusion, DLC1 is a critical regulator of various cellular processes, including cell migration, apoptosis, and actin cytoskeleton organization. Its dysregulation has been implicated in several diseases, highlighting the importance of DLC1 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3548394199

Symbol: RHG07_HUMAN

Name: Rho GTPase-activating protein 7

UniProtKB Accession Codes:

Q96QB1 B4DR10 B8PTI0 E9PDZ8 E9PF76 E9PGY9 O14868 O43199 Q7Z5R8 Q86UC6 Q9C0E0 Q9H7A2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CORUM 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 27 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 6 RefSeq 10 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9605766

Title: Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.

PubMed ID: 9605766

PubMed ID: 11214970

Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11214970

DOI: 10.1093/dnares/7.6.347

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21217778

Title: A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.

PubMed ID: 21217778

DOI: 10.1038/onc.2010.576

PubMed ID: 17190795

Title: The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1.

PubMed ID: 17190795

DOI: 10.1083/jcb.200608015

PubMed ID: 18786931

Title: Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration.

PubMed ID: 18786931

DOI: 10.1074/jbc.m800617200

PubMed ID: 19170769

Title: Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology.

PubMed ID: 19170769

DOI: 10.1111/j.1365-2443.2008.01265.x

PubMed ID: 19826001

Title: Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.

PubMed ID: 19826001

DOI: 10.1074/jbc.m109.059592

PubMed ID: 19710422

Title: DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain.

PubMed ID: 19710422

DOI: 10.1091/mbc.e09-03-0247

PubMed ID: 20798394

Title: Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.

PubMed ID: 20798394

DOI: 10.1074/mcp.m110.003665

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26427649

Title: Tensin1 positively regulates RhoA activity through its interaction with DLC1.

PubMed ID: 26427649

DOI: 10.1016/j.bbamcr.2015.09.028

PubMed ID: 26166433

Title: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.

PubMed ID: 26166433

DOI: 10.1038/ncomms8721

PubMed ID: 19317456

Title: Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.

PubMed ID: 19317456

DOI: 10.1021/bi9000936

PubMed ID: 19158340

Title: The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.

PubMed ID: 19158340

DOI: 10.1242/jcs.027482

PubMed ID: 10649492

Title: Sequence variants of DLC1 in colorectal and ovarian tumours.

PubMed ID: 10649492

DOI: 10.1002/(sici)1098-1004(200002)15:2<156::aid-humu4>3.0.co;2-4

Sequence Information:

  • Length: 1528
  • Mass: 170591
  • Checksum: 5D20F29CC606302E
  • Sequence:
    • MSVAIRKRSW EEHVTHWMGQ PFNSDDRNTA CHHGLVADSL QASMEKDATL NVDRKEKCVS 
LPDCCHGSEL RDFPGRPMGH LSKDVDENDS HEGEDQFLSL EASTETLVHV SDEDNNADLC 
LTDDKQVLNT QGQKTSGQHM IQGAGSLEKA LPIIQSNQVS SNSWGIAGET ELALVKESGE 
RKVTDSISKS LELCNEISLS EIKDAPKVNA VDTLNVKDIA PEKQLLNSAV IAQQRRKPDP 
PKDENERSTC NVVQNEFLDT PCTNRGLPLL KTDFGSCLLQ PPSCPNGMSA ENGLEKSGFS 
QHQNKSPPKV KAEDGMQCLQ LKETLATQEP TDNQVRLRKR KEIREDRDRA RLDSMVLLIM 
KLDQLDQDIE NALSTSSSPS GTPTNLRRHV PDLESGSESG ADTISVNQTR VNLSSDTEST 
DLPSSTPVAN SGTKPKTTAI QGISEKEKAE IEAKEACDWL RATGFPQYAQ LYEDFLFPID 
ISLVKREHDF LDRDAIEALC RRLNTLNKCA VMKLEISPHR KRSDDSDEDE PCAISGKWTF 
QRDSKRWSRL EEFDVFSPKQ DLVPGSPDDS HPKDGPSPGG TLMDLSERQE VSSVRSLSST 
GSLPSHAPPS EDAATPRTNS VISVCSSSNL AGNDDSFGSL PSPKELSSFS FSMKGHEKTA 
KSKTRSLLKR MESLKLKSSH HSKHKAPSKL GLIISGPILQ EGMDEEKLKQ LNCVEISALN 
GNRINVPMVR KRSVSNSTQT SSSSSQSETS SAVSTPSPVT RTRSLSACNK RVGMYLEGFD 
PFNQSTFNNV VEQNFKNRES YPEDTVFYIP EDHKPGTFPK ALTNGSFSPS GNNGSVNWRT 
GSFHGPGHIS LRRENSSDSP KELKRRNSSS SMSSRLSIYD NVPGSILYSS SGDLADLENE 
DIFPELDDIL YHVKGMQRIV NQWSEKFSDE GDSDSALDSV SPCPSSPKQI HLDVDNDRTT 
PSDLDSTGNS LNEPEEPSEI PERRDSGVGA SLTRSNRHRL RWHSFQSSHR PSLNSVSLQI 
NCQSVAQMNL LQKYSLLKLT ALLEKYTPSN KHGFSWAVPK FMKRIKVPDY KDRSVFGVPL 
TVNVQRTGQP LPQSIQQAMR YLRNHCLDQV GLFRKSGVKS RIQALRQMNE GAIDCVNYEG 
QSAYDVADML KQYFRDLPEP LMTNKLSETF LQIYQYVPKD QRLQAIKAAI MLLPDENREV 
LQTLLYFLSD VTAAVKENQM TPTNLAVCLA PSLFHLNTLK RENSSPRVMQ RKQSLGKPDQ 
KDLNENLAAT QGLAHMIAEC KKLFQVPEEM SRCRNSYTEQ ELKPLTLEAL GHLGNDDSAD 
YQHFLQDCVD GLFKEVKEKF KGWVSYSTSE QAELSYKKVS EGPPLRLWRS VIEVPAVPEE 
ILKRLLKEQH LWDVDLLDSK VIEILDSQTE IYQYVQNSMA PHPARDYVVL RTWRTNLPKG 
ACALLLTSVD HDRAPVVGVR VNVLLSRYLI EPCGPGKSKL TYMCRVDLRG HMPEWYTKSF 
GHLCAAEVVK IRDSFSNQNT ETKDTKSR

Genular Protein ID: 865060207

Symbol: A8K119_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K119

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1091
  • Mass: 122825
  • Checksum: 359F3BB4B950A417
  • Sequence:
    • MCRKKPDTMI LTQIEAKEAC DWLRATGFPQ YAQLYEDFLF PIDISLVKRE HDFLDRDAIE 
ALCRRLNTLN KCAVMKLEIS PHRKRSDDSD EDEPCAISGK WTFQRDSKRW SRLEEFDVFS 
PKQDLVPGSP DDSHPKDGPS PGGTLMDLSE RQEVSSVRSL SSTGSLPSHA PPSEDAATPR 
TNSVISVCSS SNLAGNDDSF GSLPSPKELS SFSFSMKGHE KTAKSKTRSL LKRMESLKLK 
SSHHSKHKAP SKLGLIISGP ILQEGMDEEK LKQLNCVEIS ALNGNRINVP MVRKRSVSNS 
TQTSSSSSQS EASSAVSTPS PVTRTRSLSA CNKRVGMYLE GFDPFNQSTF NNVVEQNFKN 
RESYPEDTVF YIPEDHKPGT FPKALTNGSF SPSGNNGSVN WRTGSFHGPG HISLRRENSS 
DSPKELKRRN SSSSMSSRLS IYDNVPGSIL YSSSGDLADL ENEDIFPELD DILYHVKGMQ 
RIVNQWSEKF SDEGDSDSAL DSVSPCPSSP KQIHLDVDND RTTPSDLDST GNSLNEPEEP 
SEIPERRDSG VGASLTRSNR HRLRWHSFQS SHRPSLNSVS LQINCQSVAQ MNLLQKYSLL 
KLTALLEKYT PSNKHGFSWA VPKFMKRIKV PDYKDRSVFG VPLTVNVQRT GQPLPQSIQQ 
AMRYLRNHCL DQVGLFRKSG VKSRIQALRQ MNEGAIDCVN YEGQSAYDVA DMLKQYFRDL 
PEPLMTNKLS ETFLQIYQYV PKDQRLQAIK AAIMLLPDEN REVLQTLLYF LSDVTAAVKE 
NQMTPTNLAV CLAPSLFHLN TLRRENSSPR VMQRKQSLGK PDQKDLNENL AATQGLAHMI 
AECKKLFQVP EEMSRCRNSY TEQELKPLTL EALGHLGNDD SADYQHFLQD CVDGLFKEVK 
EKFKGWVSYS TSEQAELSYK KVSEGPPLRL WRSVIEVPAV PEEILKRLLK EQHLWDVDLL 
DSKVIEILDS QTEIYQYVQN SMAPHPARDY VVLRTWRTNL PKGACALLLT SVDHDRAPVV 
GVRVNVLLSR YLIEPCGPGK SKLTYMCRVD LRGHMPEWYT KSFGHLCAAE VVKIRDSFSN 
QNTETKDTKS R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.