Details for: ATP8A1

Gene ID: 10396

Symbol: ATP8A1

Ensembl ID: ENSG00000124406

Description: ATPase phospholipid transporting 8A1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.97
    Marker Score: 134,089
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.42
    Marker Score: 8,192
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.04
    Marker Score: 4,277
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.9
    Marker Score: 13,416
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.61
    Marker Score: 7,444
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.57
    Marker Score: 51,207
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.52
    Marker Score: 19,327
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.5
    Marker Score: 37,314
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.35
    Marker Score: 89,312
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.32
    Marker Score: 85,618
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3
    Marker Score: 3,857
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.27
    Marker Score: 1,273
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.23
    Marker Score: 47,510
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.22
    Marker Score: 11,627
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.11
    Marker Score: 19,852
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,706
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.03
    Marker Score: 7,858
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.98
    Marker Score: 31,837
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,032
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.88
    Marker Score: 19,396
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,895
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.84
    Marker Score: 2,227
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.81
    Marker Score: 7,360
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.75
    Marker Score: 1,314
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.69
    Marker Score: 37,836
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.67
    Marker Score: 6,928
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.64
    Marker Score: 629
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.61
    Marker Score: 933
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.6
    Marker Score: 5,677
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.59
    Marker Score: 2,448
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.52
    Marker Score: 1,831
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.51
    Marker Score: 6,284
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,670
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.43
    Marker Score: 724
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.42
    Marker Score: 9,270
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.39
    Marker Score: 912
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.35
    Marker Score: 1,664
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.33
    Marker Score: 1,153
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.3
    Marker Score: 3,658
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.3
    Marker Score: 683
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.28
    Marker Score: 2,245
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.26
    Marker Score: 6,772
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.26
    Marker Score: 3,725
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19,567
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.24
    Marker Score: 613
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.23
    Marker Score: 636
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.23
    Marker Score: 389
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.19
    Marker Score: 714
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.19
    Marker Score: 8,947
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.17
    Marker Score: 1,612
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.12
    Marker Score: 653
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.11
    Marker Score: 1,185
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.11
    Marker Score: 293
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.09
    Marker Score: 1,363
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.05
    Marker Score: 425
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2,119
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2,450
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.01
    Marker Score: 603
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1
    Marker Score: 773
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1
    Marker Score: 323
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1
    Marker Score: 2,500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,703
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,929
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.98
    Marker Score: 576
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.98
    Marker Score: 681
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.95
    Marker Score: 457
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.95
    Marker Score: 409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.94
    Marker Score: 1,515
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.93
    Marker Score: 226
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.93
    Marker Score: 221
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.93
    Marker Score: 2,908
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.92
    Marker Score: 523
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1,495
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.91
    Marker Score: 284
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,711
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.9
    Marker Score: 525
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.89
    Marker Score: 1,266
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.89
    Marker Score: 2,523
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.89
    Marker Score: 1,584
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.88
    Marker Score: 370
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5,292
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.87
    Marker Score: 1,087
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,903
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.85
    Marker Score: 859
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.84
    Marker Score: 312
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.84
    Marker Score: 905
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.83
    Marker Score: 3,468
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.83
    Marker Score: 953
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.81
    Marker Score: 2,566
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.81
    Marker Score: 806
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8
    Marker Score: 14,213
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.8
    Marker Score: 752
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.8
    Marker Score: 604

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipid Transport:** ATP8A1 is a type II transmembrane protein that utilizes ATP hydrolysis to transport phospholipids across cellular membranes. This process is crucial for maintaining lipid homeostasis and regulating membrane fluidity. 2. **Cellular Localization:** ATP8A1 is predominantly expressed in neurons, glial cells, and immune cells, including neutrophils and microglia. Its expression is also detected in chromaffin cells and astrocytes. 3. **Protein Interactions:** ATP8A1 interacts with various proteins, including phospholipid-binding proteins, ion channels, and membrane-associated proteins. 4. **Regulatory Mechanisms:** ATP8A1 is regulated by post-translational modifications, including phosphorylation and ubiquitination. **Pathways and Functions:** 1. **Phospholipid Translocation:** ATP8A1 is involved in the transport of phospholipids across cellular membranes, regulating lipid homeostasis and membrane fluidity. 2. **Ion Channel Transport:** ATP8A1 interacts with ion channels, modulating their activity and regulating cellular excitability. 3. **Immune Response:** ATP8A1 is expressed in immune cells, where it plays a role in regulating neutrophil degranulation and immune cell migration. 4. **Neurotransmission:** ATP8A1 is expressed in neurons, where it may regulate neurotransmitter release and synaptic plasticity. 5. **Cell Signaling:** ATP8A1 is involved in various cell signaling pathways, including those regulating cell migration, proliferation, and differentiation. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of ATP8A1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immunological Disorders:** ATP8A1 dysfunction has been linked to immunological disorders, such as autoimmune diseases and cancer. 3. **Cancer:** ATP8A1 expression is altered in various types of cancer, including glioblastoma and melanoma. 4. **Neurodevelopmental Disorders:** ATP8A1 mutations have been identified in individuals with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, ATP8A1 is a crucial gene that plays a significant role in maintaining cellular homeostasis, regulating phospholipid trafficking, and modulating immune responses. Its dysregulation has been implicated in various neurological and immunological disorders, highlighting the importance of further research into the functions and mechanisms of ATP8A1.

Genular Protein ID: 565356115

Symbol: AT8A1_HUMAN

Name: ATPase class I type 8A member 1

UniProtKB Accession Codes:

Q9Y2Q0 Q32M35 Q32M36 Q4W5J7 Q4W5P2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 27 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 9 EMDB 12 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 8 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 2 SFLD 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10198212

Title: Cloning, expression, and chromosomal mapping of a human ATPase II gene, member of the third subfamily of P-type ATPases and orthologous to the presumed bovine and murine aminophospholipid translocase.

PubMed ID: 10198212

DOI: 10.1006/bbrc.1999.0347

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20947505

Title: Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.

PubMed ID: 20947505

DOI: 10.1074/jbc.m110.139006

PubMed ID: 20961850

Title: CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.

PubMed ID: 20961850

DOI: 10.1074/jbc.m110.139543

PubMed ID: 21914794

Title: ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.

PubMed ID: 21914794

DOI: 10.1074/jbc.m111.281006

PubMed ID: 30674456

Title: Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets.

PubMed ID: 30674456

DOI: 10.1182/bloodadvances.2018023473

PubMed ID: 31416931

Title: Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.

PubMed ID: 31416931

DOI: 10.1126/science.aay3353

Sequence Information:

  • Length: 1164
  • Mass: 131369
  • Checksum: CE1EAF0206CD36F7
  • Sequence:
    • MPTMRRTVSE IRSRAEGYEK TDDVSEKTSL ADQEEVRTIF INQPQLTKFC NNHVSTAKYN 
IITFLPRFLY SQFRRAANSF FLFIALLQQI PDVSPTGRYT TLVPLLFILA VAAIKEIIED 
IKRHKADNAV NKKQTQVLRN GAWEIVHWEK VAVGEIVKVT NGEHLPADLI SLSSSEPQAM 
CYIETSNLDG ETNLKIRQGL PATSDIKDVD SLMRISGRIE CESPNRHLYD FVGNIRLDGH 
GTVPLGADQI LLRGAQLRNT QWVHGIVVYT GHDTKLMQNS TSPPLKLSNV ERITNVQILI 
LFCILIAMSL VCSVGSAIWN RRHSGKDWYL NLNYGGASNF GLNFLTFIIL FNNLIPISLL 
VTLEVVKFTQ AYFINWDLDM HYEPTDTAAM ARTSNLNEEL GQVKYIFSDK TGTLTCNVMQ 
FKKCTIAGVA YGHVPEPEDY GCSPDEWQNS QFGDEKTFSD SSLLENLQNN HPTAPIICEF 
LTMMAVCHTA VPEREGDKII YQAASPDEGA LVRAAKQLNF VFTGRTPDSV IIDSLGQEER 
YELLNVLEFT SARKRMSVIV RTPSGKLRLY CKGADTVIYD RLAETSKYKE ITLKHLEQFA 
TEGLRTLCFA VAEISESDFQ EWRAVYQRAS TSVQNRLLKL EESYELIEKN LQLLGATAIE 
DKLQDQVPET IETLMKADIK IWILTGDKQE TAINIGHSCK LLKKNMGMIV INEGSLDGTR 
ETLSRHCTTL GDALRKENDF ALIIDGKTLK YALTFGVRQY FLDLALSCKA VICCRVSPLQ 
KSEVVEMVKK QVKVVTLAIG DGANDVSMIQ TAHVGVGISG NEGLQAANSS DYSIAQFKYL 
KNLLMIHGAW NYNRVSKCIL YCFYKNIVLY IIEIWFAFVN GFSGQILFER WCIGLYNVMF 
TAMPPLTLGI FERSCRKENM LKYPELYKTS QNALDFNTKV FWVHCLNGLF HSVILFWFPL 
KALQYGTAFG NGKTSDYLLL GNFVYTFVVI TVCLKAGLET SYWTWFSHIA IWGSIALWVV 
FFGIYSSLWP AIPMAPDMSG EAAMLFSSGV FWMGLLFIPV ASLLLDVVYK VIKRTAFKTL 
VDEVQELEAK SQDPGAVVLG KSLTERAQLL KNVFKKNHVN LYRSESLQQN LLHGYAFSQD 
ENGIVSQSEV IRAYDTTKQR PDEW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.