Details for: MYL9

Gene ID: 10398

Symbol: MYL9

Ensembl ID: ENSG00000101335

Description: myosin light chain 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.79
    Marker Score: 7,543
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.3
    Marker Score: 5,174
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 4.12
    Marker Score: 3,924
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.08
    Marker Score: 2,904
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 4.06
    Marker Score: 6,255
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.02
    Marker Score: 71,379
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.81
    Marker Score: 7,164
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.8
    Marker Score: 1,250
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.35
    Marker Score: 4,599
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.29
    Marker Score: 43,769
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.27
    Marker Score: 7,183
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.16
    Marker Score: 41,676
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.14
    Marker Score: 2,066
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 3.03
    Marker Score: 1,147
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.02
    Marker Score: 3,732
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.94
    Marker Score: 12,700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.89
    Marker Score: 64,588
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.85
    Marker Score: 914
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.82
    Marker Score: 1,526
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.79
    Marker Score: 1,996
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.72
    Marker Score: 859
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.68
    Marker Score: 30,143
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.66
    Marker Score: 7,231
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.65
    Marker Score: 6,949
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.65
    Marker Score: 749
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.5
    Marker Score: 5,878
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.39
    Marker Score: 5,837
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.39
    Marker Score: 1,394
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.37
    Marker Score: 8,443
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.27
    Marker Score: 666
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.26
    Marker Score: 574
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.2
    Marker Score: 14,321
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.17
    Marker Score: 487
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.16
    Marker Score: 9,021
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.13
    Marker Score: 8,860
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.12
    Marker Score: 1,805
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.05
    Marker Score: 10,049
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.04
    Marker Score: 12,121
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.03
    Marker Score: 2,191
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.01
    Marker Score: 3,090
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.94
    Marker Score: 1,875
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.9
    Marker Score: 3,788
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.84
    Marker Score: 655
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.83
    Marker Score: 18,439
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.76
    Marker Score: 1,114
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.76
    Marker Score: 2,982
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.71
    Marker Score: 2,804
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.69
    Marker Score: 390
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.68
    Marker Score: 581
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.67
    Marker Score: 439
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.64
    Marker Score: 901
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.61
    Marker Score: 672
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.57
    Marker Score: 445
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.56
    Marker Score: 399
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.56
    Marker Score: 699
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.49
    Marker Score: 768
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.49
    Marker Score: 1,710
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.47
    Marker Score: 964
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.44
    Marker Score: 1,095
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.43
    Marker Score: 814
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.42
    Marker Score: 1,338
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.37
    Marker Score: 1,075
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.36
    Marker Score: 46,333
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.36
    Marker Score: 2,610
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.3
    Marker Score: 320
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.29
    Marker Score: 860
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.28
    Marker Score: 1,858
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.28
    Marker Score: 20,520
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.22
    Marker Score: 304
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.22
    Marker Score: 559
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.21
    Marker Score: 304
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.18
    Marker Score: 1,901
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.16
    Marker Score: 1,001
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.16
    Marker Score: 301
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.1
    Marker Score: 246
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.1
    Marker Score: 986
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.1
    Marker Score: 458
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.09
    Marker Score: 2,778
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.06
    Marker Score: 1,423
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16,513
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.04
    Marker Score: 1,079
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.03
    Marker Score: 1,041
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 1.02
    Marker Score: 288
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.02
    Marker Score: 370
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.02
    Marker Score: 438
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 1.02
    Marker Score: 314
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.01
    Marker Score: 2,556
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.01
    Marker Score: 1,082
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1
    Marker Score: 247
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,724
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,953
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.99
    Marker Score: 1,050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.98
    Marker Score: 1,053
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.98
    Marker Score: 5,135
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.97
    Marker Score: 1,361
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: The MLC9 protein is a regulatory subunit of the myosin II complex, consisting of a globular head and a long tail domain. 2. **Function**: MLC9 plays a crucial role in regulating muscle contraction, cell migration, and platelet aggregation by interacting with the myosin heavy chain and other regulatory proteins. 3. **Expression**: The MLC9 gene is widely expressed in various cell types, including uterine smooth muscle cells, type I pneumocytes, and cardiac muscle cells. 4. **Regulation**: The expression and activity of MLC9 are tightly regulated by various signaling pathways, including those involved in axon guidance, developmental biology, and signaling by Rho GTPases. **Pathways and Functions** The MLC9 protein is involved in various cellular processes, including: 1. **Muscle Contraction**: MLC9 regulates muscle contraction by interacting with the myosin heavy chain and other regulatory proteins. 2. **Cell Migration**: MLC9 plays a role in cell migration by regulating the dynamics of the actin cytoskeleton. 3. **Platelet Aggregation**: MLC9 is involved in platelet aggregation by regulating the dynamics of the actin cytoskeleton and the interaction with the myosin heavy chain. 4. **Axon Guidance**: MLC9 regulates axon guidance by interacting with the myosin heavy chain and other regulatory proteins involved in axon outgrowth and guidance. 5. **Developmental Biology**: MLC9 is involved in developmental biology by regulating the dynamics of the actin cytoskeleton and the interaction with other regulatory proteins involved in cell migration and differentiation. **Clinical Significance** Dysregulation of the MLC9 protein has been implicated in various diseases, including: 1. **Muscular Dystrophy**: Mutations in the MLC9 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiovascular Disease**: Dysregulation of MLC9 has been implicated in cardiovascular disease, including hypertension, atherosclerosis, and cardiac arrhythmias. 3. **Neurological Disorders**: MLC9 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 4. **Cancer**: Dysregulation of MLC9 has been implicated in cancer, including metastasis and tumor progression. In conclusion, the MYL9 gene encodes for the MLC9 protein, a crucial component of the muscle contraction machinery. The protein is involved in various cellular processes, including muscle contraction, cell migration, and platelet aggregation. Dysregulation of MLC9 has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2308205350

Symbol: MYL9_HUMAN

Name: Myosin regulatory light polypeptide 9

UniProtKB Accession Codes:

P24844 E1P5T6 Q9BQL9 Q9BUF9 Q9H136

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2526655

Title: Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells.

PubMed ID: 2526655

DOI: 10.1021/bi00435a059

PubMed ID: 11942626

Title: Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells.

PubMed ID: 11942626

DOI: 10.1247/csf.26.677

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18854160

Title: A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.

PubMed ID: 18854160

DOI: 10.1016/j.cell.2008.09.018

PubMed ID: 21072057

Title: Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling.

PubMed ID: 21072057

DOI: 10.1038/cdd.2010.140

PubMed ID: 21457715

Title: Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.

PubMed ID: 21457715

DOI: 10.1016/j.febslet.2011.03.054

PubMed ID: 21408167

Title: New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

PubMed ID: 21408167

DOI: 10.1371/journal.pone.0017344

PubMed ID: 29453416

Title: Homozygous deletion in MYL9 expands the molecular basis of megacystis-microcolon-intestinal hypoperistalsis syndrome.

PubMed ID: 29453416

DOI: 10.1038/s41431-017-0055-5

PubMed ID: 33031641

Title: Compound heterozygous loss of function variants in MYL9 in a child with megacystis-microcolon-intestinal hypoperistalsis syndrome.

PubMed ID: 33031641

DOI: 10.1002/mgg3.1516

Sequence Information:

  • Length: 172
  • Mass: 19827
  • Checksum: 4C9839E85154CDA8
  • Sequence:
    • MSSKRAKAKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS 
LGKNPTDEYL EGMMSEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEASGFIHE 
DHLRELLTTM GDRFTDEEVD EMYREAPIDK KGNFNYVEFT RILKHGAKDK DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.