Details for: CDS1

Gene ID: 1040

Symbol: CDS1

Ensembl ID: ENSG00000163624

Description: CDP-diacylglycerol synthase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.9826
    Cell Significance Index: -28.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.2728
    Cell Significance Index: -24.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.0388
    Cell Significance Index: -28.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.9072
    Cell Significance Index: -23.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3294
    Cell Significance Index: -30.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.2293
    Cell Significance Index: 136.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2447
    Cell Significance Index: -9.2900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.9331
    Cell Significance Index: 29.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0453
    Cell Significance Index: 44.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6388
    Cell Significance Index: 85.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6186
    Cell Significance Index: 176.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5887
    Cell Significance Index: 14.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4958
    Cell Significance Index: 39.9400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.4780
    Cell Significance Index: 14.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2745
    Cell Significance Index: 207.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1187
    Cell Significance Index: 70.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0610
    Cell Significance Index: 579.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9943
    Cell Significance Index: 45.0700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9901
    Cell Significance Index: 10.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9740
    Cell Significance Index: 27.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9477
    Cell Significance Index: 13.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9335
    Cell Significance Index: 187.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9195
    Cell Significance Index: 51.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8641
    Cell Significance Index: 21.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8219
    Cell Significance Index: 148.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8198
    Cell Significance Index: 17.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7254
    Cell Significance Index: 19.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6614
    Cell Significance Index: 45.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6488
    Cell Significance Index: 28.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6124
    Cell Significance Index: 23.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5947
    Cell Significance Index: 27.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5566
    Cell Significance Index: 12.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4743
    Cell Significance Index: 170.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4572
    Cell Significance Index: 56.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4215
    Cell Significance Index: 12.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4059
    Cell Significance Index: 280.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2647
    Cell Significance Index: 9.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2601
    Cell Significance Index: 29.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2502
    Cell Significance Index: 47.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1898
    Cell Significance Index: 83.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1564
    Cell Significance Index: 5.0100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1464
    Cell Significance Index: 0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1377
    Cell Significance Index: 9.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1333
    Cell Significance Index: 17.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1225
    Cell Significance Index: 24.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1010
    Cell Significance Index: 17.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0874
    Cell Significance Index: 1.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0843
    Cell Significance Index: 8.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0789
    Cell Significance Index: 0.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0782
    Cell Significance Index: 2.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0680
    Cell Significance Index: 5.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0266
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0254
    Cell Significance Index: 47.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0231
    Cell Significance Index: 14.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0231
    Cell Significance Index: 17.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0121
    Cell Significance Index: 22.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0017
    Cell Significance Index: -1.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0040
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0096
    Cell Significance Index: -5.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0118
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -17.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0154
    Cell Significance Index: -1.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0193
    Cell Significance Index: -0.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0279
    Cell Significance Index: -15.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0389
    Cell Significance Index: -5.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0557
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0608
    Cell Significance Index: -7.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0737
    Cell Significance Index: -21.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0759
    Cell Significance Index: -15.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1216
    Cell Significance Index: -13.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1283
    Cell Significance Index: -13.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1516
    Cell Significance Index: -20.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1583
    Cell Significance Index: -20.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1924
    Cell Significance Index: -5.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2447
    Cell Significance Index: -15.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2457
    Cell Significance Index: -25.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2479
    Cell Significance Index: -3.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2497
    Cell Significance Index: -29.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3082
    Cell Significance Index: -18.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3164
    Cell Significance Index: -25.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3508
    Cell Significance Index: -7.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3620
    Cell Significance Index: -12.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3689
    Cell Significance Index: -4.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3999
    Cell Significance Index: -11.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4061
    Cell Significance Index: -6.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4217
    Cell Significance Index: -21.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4346
    Cell Significance Index: -22.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4645
    Cell Significance Index: -28.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5168
    Cell Significance Index: -6.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5499
    Cell Significance Index: -6.9400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5785
    Cell Significance Index: -5.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5917
    Cell Significance Index: -25.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5975
    Cell Significance Index: -14.3300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.5977
    Cell Significance Index: -5.4900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6022
    Cell Significance Index: -8.4400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6227
    Cell Significance Index: -5.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6233
    Cell Significance Index: -22.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CDS1 is a CDP-diacylglycerol synthase, responsible for catalyzing the condensation of CDP-diacylglycerol with choline to produce phosphatidylcholine (PC). 2. **Cellular Localization:** CDS1 is predominantly localized in the endoplasmic reticulum (ER), where it plays a crucial role in lipid metabolism and synthesis. 3. **Subcellular Distribution:** The enzyme is also found in the ER membrane and lipid droplets, highlighting its involvement in lipid storage and regulation. 4. **Regulatory Mechanisms:** CDS1 is subject to various regulatory mechanisms, including protein-protein interactions and post-translational modifications, which modulate its activity and expression levels. **Pathways and Functions:** 1. **CDP-Choline Pathway:** CDS1 is integral to the CDP-choline pathway, which is responsible for producing phosphatidylcholine (PC) and other phospholipids. 2. **Glycerophospholipid Biosynthesis:** As a key enzyme in the biosynthesis of phospholipids, CDS1 contributes to the formation of various glycerophospholipids, including PC, phosphatidylethanolamine (PE), and phosphatidylinositol (PI). 3. **Lipid Droplet Formation:** CDS1 is involved in the regulation of lipid droplet formation and maintenance, which is essential for lipid storage and cellular homeostasis. 4. **Signal Transduction:** The enzyme's activity is also linked to signal transduction pathways, including the regulation of fat cell differentiation and phototransduction. **Clinical Significance:** 1. **Lipid Metabolic Disorders:** Dysregulation of CDS1 has been implicated in various lipid metabolic disorders, including hypercholesterolemia and fatty liver disease. 2. **Neurological Disorders:** The enzyme's role in lipid metabolism and signal transduction makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer Research:** CDS1 has been identified as a potential biomarker for cancer diagnosis and prognosis, as its expression levels are altered in various cancer types. In conclusion, CDS1 is a crucial enzyme in lipid metabolism and cellular signaling, with implications for various diseases and disorders. Further research is needed to fully elucidate the mechanisms of CDS1 and its role in human health and disease.

Genular Protein ID: 1333253304

Symbol: CDS1_HUMAN

Name: CDP-DAG synthase 1

UniProtKB Accession Codes:

Q92903 B2RAL5 O00163

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 46 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 18 SIGNOR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8863531

Title: Cloning of CDP-diacylglycerol synthase from a human neuronal cell line.

PubMed ID: 8863531

DOI: 10.1046/j.1471-4159.1996.67052200.x

PubMed ID: 9115637

Title: Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA.

PubMed ID: 9115637

DOI: 10.1089/dna.1997.16.281

PubMed ID: 9407135

Title: The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.

PubMed ID: 9407135

DOI: 10.1074/jbc.272.52.33402

PubMed ID: 9806839

Title: Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes.

PubMed ID: 9806839

DOI: 10.1006/geno.1998.5547

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25375833

Title: Distinct properties of the two isoforms of CDP-diacylglycerol synthase.

PubMed ID: 25375833

DOI: 10.1021/bi501250m

PubMed ID: 26946540

Title: CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.

PubMed ID: 26946540

DOI: 10.1194/jlr.m060574

PubMed ID: 31548309

Title: CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms.

PubMed ID: 31548309

DOI: 10.1074/jbc.ra119.009992

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 461
  • Mass: 53304
  • Checksum: E9D761BA285A5AB1
  • Sequence:
    • MLELRHRGSC PGPREAVSPP HREGEAAGGD HETESTSDKE TDIDDRYGDL DSRTDSDIPE 
IPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF FLIIYMGSFM LMLLVLGIQV 
KCFHEIITIG YRVYHSYDLP WFRTLSWYFL LCVNYFFYGE TVADYFATFV QREEQLQFLI 
RYHRFISFAL YLAGFCMFVL SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI 
WFLVPISSVI CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVVF GFIAAYVLSK 
YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ TYSLPPFLKA VLRQERVSLY PFQIHSIALS 
TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF DCQYLMATFV HVYITSFIRG 
PNPSKVLQQL LVLQPEQQLN IYKTLKTHLI EKGILQPTLK V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.