Details for: PEMT

Gene ID: 10400

Symbol: PEMT

Ensembl ID: ENSG00000133027

Description: phosphatidylethanolamine N-methyltransferase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.8
    Marker Score: 964
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.96
    Marker Score: 8,454
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.87
    Marker Score: 3,264
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.86
    Marker Score: 20,952
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.74
    Marker Score: 700
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.58
    Marker Score: 1,700
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,065
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.46
    Marker Score: 5,398
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20,745
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.25
    Marker Score: 2,378
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.24
    Marker Score: 5,357
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.16
    Marker Score: 7,482
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.1
    Marker Score: 5,895
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2,253
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.08
    Marker Score: 1,141
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.07
    Marker Score: 515
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.06
    Marker Score: 550
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.06
    Marker Score: 583
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.05
    Marker Score: 10,609
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.05
    Marker Score: 298
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.03
    Marker Score: 512
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.02
    Marker Score: 2,787
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.01
    Marker Score: 3,311
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,951
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,395
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.96
    Marker Score: 5,686
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.95
    Marker Score: 2,174
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.95
    Marker Score: 320
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 294
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.94
    Marker Score: 626
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.93
    Marker Score: 1,048
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 559
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.92
    Marker Score: 578
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.92
    Marker Score: 1,316
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.91
    Marker Score: 1,499
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.91
    Marker Score: 287
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,708
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9
    Marker Score: 1,534
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.9
    Marker Score: 2,120
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.89
    Marker Score: 457
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1,796
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.88
    Marker Score: 5,712
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.87
    Marker Score: 927
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.87
    Marker Score: 196
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.86
    Marker Score: 811
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.85
    Marker Score: 800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.85
    Marker Score: 906
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.85
    Marker Score: 438
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,809
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.84
    Marker Score: 1,992
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.83
    Marker Score: 1,953
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.81
    Marker Score: 190
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.81
    Marker Score: 381
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 545
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.79
    Marker Score: 872
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1,159
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.78
    Marker Score: 531
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.78
    Marker Score: 1,249
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.77
    Marker Score: 367
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.76
    Marker Score: 1,014
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28,603
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.75
    Marker Score: 1,190
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.75
    Marker Score: 9,846
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.74
    Marker Score: 1,935
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.72
    Marker Score: 5,383
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.72
    Marker Score: 2,785
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.72
    Marker Score: 1,624
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.71
    Marker Score: 879
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.7
    Marker Score: 257
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.69
    Marker Score: 25,583
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,898
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.69
    Marker Score: 221
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.68
    Marker Score: 431
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.68
    Marker Score: 585
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 432
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.67
    Marker Score: 840
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.67
    Marker Score: 484
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.66
    Marker Score: 130
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.66
    Marker Score: 275
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.66
    Marker Score: 391
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.65
    Marker Score: 318
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.65
    Marker Score: 6,759
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.65
    Marker Score: 412
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.65
    Marker Score: 838
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.65
    Marker Score: 22,413
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.65
    Marker Score: 340

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molecular Structure:** PEMT is a cytosolic enzyme, consisting of two subunits, a catalytic subunit and a regulatory subunit. 2. **Subcellular Localization:** PEMT is localized to the endoplasmic reticulum (ER) and the cytosol. 3. **Molecular Weight:** The molecular weight of PEMT is approximately 55 kDa. 4. **Isoforms:** Two isoforms of PEMT have been identified, PEMT1 and PEMT2, which are encoded by different genes. **Pathways and Functions:** 1. **Glycerophospholipid Biosynthesis:** PEMT plays a critical role in the biosynthesis of phosphatidylcholine, a key component of cellular membranes. 2. **Methylation:** PEMT catalyzes the methylation of phosphatidylethanolamine to produce phosphatidyl-n-methylethanolamine, a precursor to phosphatidylcholine. 3. **Cell Signaling:** PEMT has been implicated in cell signaling pathways, including the regulation of cell growth and differentiation. 4. **Thermogenesis:** PEMT has been shown to play a role in the regulation of cold-induced thermogenesis, a process by which the body generates heat in response to cold temperatures. 5. **Lipid Metabolism:** PEMT is involved in the regulation of lipid metabolism, including the synthesis and degradation of phospholipids. **Clinical Significance:** 1. **Cancer:** Dysregulation of PEMT has been linked to various types of cancer, including colorectal, breast, and lung cancer. 2. **Neurological Disorders:** PEMT has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease:** PEMT has been shown to play a role in the regulation of lipid metabolism, which is critical in the development of cardiovascular disease. 4. **Thermoregulation:** Dysregulation of PEMT has been linked to abnormal thermoregulation, which can lead to hypothermia or hyperthermia. In conclusion, PEMT is a critical enzyme involved in lipid metabolism and beyond. Its dysregulation has been linked to various diseases, including cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the role of PEMT in human health and disease.

Genular Protein ID: 1274385929

Symbol: PEMT_HUMAN

Name: PEMT2

UniProtKB Accession Codes:

Q9UBM1 A8MZ66 B4DY41 D3DXC3 Q6IAQ5 Q86VL3 Q9BW86 Q9UHY6 Q9Y6V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 92 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 6 EMBL 18 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 36 STRING 1 SignaLink 1 SwissLipids 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9989271

Title: Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.

PubMed ID: 9989271

DOI: 10.1016/s0005-2760(98)00147-7

PubMed ID: 11420179

Title: Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene.

PubMed ID: 11420179

DOI: 10.1016/s1388-1981(01)00122-6

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12431977

Title: Membrane topography of human phosphatidylethanolamine N-methyltransferase.

PubMed ID: 12431977

DOI: 10.1074/jbc.m210904200

PubMed ID: 12842883

Title: Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase.

PubMed ID: 12842883

DOI: 10.1074/jbc.m306308200

PubMed ID: 15927961

Title: Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase.

PubMed ID: 15927961

DOI: 10.1074/jbc.m504658200

PubMed ID: 17456783

Title: Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.

PubMed ID: 17456783

DOI: 10.1096/fj.07-8227com

PubMed ID: 20860552

Title: Functional analysis of two isoforms of phosphatidylethanolamine N-methyltransferase.

PubMed ID: 20860552

DOI: 10.1042/bj20100490

Sequence Information:

  • Length: 199
  • Mass: 22134
  • Checksum: 98C07AB54B3B4E6A
  • Sequence:
    • MTRLLGYVDP LDPSFVAAVI TITFNPLYWN VVARWEHKTR KLSRAFGSPY LACYSLSVTI 
LLLNFLRSHC FTQAMLSQPR MESLDTPAAY SLGLALLGLG VVLVLSSFFA LGFAGTFLGD 
YFGILKEARV TVFPFNILDN PMYWGSTANY LGWAIMHASP TGLLLTVLVA LTYIVALLYE 
EPFTAEIYRQ KASGSHKRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.