Details for: PIAS3

Gene ID: 10401

Symbol: PIAS3

Ensembl ID: ENSG00000131788

Description: protein inhibitor of activated STAT 3

Associated with

Other Information

Genular Protein ID: 1686164322

Symbol: PIAS3_HUMAN

Name: E3 SUMO-protein ligase PIAS3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10319586

Title: Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3).

PubMed ID: 10319586

DOI: 10.1007/s100380050141

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9388184

Title: Specific inhibition of Stat3 signal transduction by PIAS3.

PubMed ID: 9388184

DOI: 10.1126/science.278.5344.1803

PubMed ID: 11071847

Title: Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells.

PubMed ID: 11071847

DOI: 10.1006/bbrc.2000.3753

PubMed ID: 11060035

Title: The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.

PubMed ID: 11060035

DOI: 10.1093/emboj/19.21.5845

PubMed ID: 14715251

Title: ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3.

PubMed ID: 14715251

DOI: 10.1016/j.bbrc.2003.12.054

PubMed ID: 15208321

Title: Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation.

PubMed ID: 15208321

DOI: 10.1074/jbc.m401753200

PubMed ID: 20516148

Title: TRIM8 modulates STAT3 activity through negative regulation of PIAS3.

PubMed ID: 20516148

DOI: 10.1242/jcs.068981

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 25406032

Title: Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.

PubMed ID: 25406032

DOI: 10.1038/ncomms6483

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24651376

Title: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.

PubMed ID: 24651376

DOI: 10.1371/journal.pone.0092746

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 628
  • Mass: 68017
  • Checksum: 7C06EF599D48F87D
  • Sequence:
  • MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 
    YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL LAPGTLLGPK REVDMHPPLP 
    QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQVQ QILTSREVLP 
    GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR 
    PINITPLARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS 
    RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK 
    KPTWTCPVCD KKAPYESLII DGLFMEILSS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP 
    PGYGLDGLQY SPVQGGDPSE NKKKVEVIDL TIESSSDEED LPPTKKHCSV TSAAIPALPG 
    SKGVLTSGHQ PSSVLRSPAM GTLGGDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ 
    HYGPSVITSL DEQDALGHFF QYRGTPSHFL GPLAPTLGSS HCSATPAPPP GRVSSIVAPG 
    GALREGHGGP LPSGPSLTGC RSDIISLD

Genular Protein ID: 1500194988

Symbol: B3KNI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 628
  • Mass: 68001
  • Checksum: 1002AE16F00BD531
  • Sequence:
  • MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 
    YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL LAPGTLLGPK REVDMHPPLP 
    QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQVQ QILTSREVLP 
    GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR 
    PINITPPARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS 
    RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK 
    KPTWTCPVCD KKAPYESLII DGLFMEILSS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP 
    PGYGLDGLQY SPVQGGDPSE NKKKVEVIDL TIESSSDEED LPPTKKHCSV TSAAIPALPG 
    SKGVLTSGHQ PSSVLRSPAM GTLGGDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ 
    HYGPSVITSL DEQDALGHFF QYRGTPSHFL GPLAPTLGSS HCSATPAPPP GRVSSIVAPG 
    GALREGHGGP LPSGPSLTGC RSDIISLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.