Details for: PIAS3

Gene ID: 10401

Symbol: PIAS3

Ensembl ID: ENSG00000131788

Description: protein inhibitor of activated STAT 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.72
    Marker Score: 2,174
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.07
    Marker Score: 588
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.06
    Marker Score: 708
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,993
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.92
    Marker Score: 7,976
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,018
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.86
    Marker Score: 1,074
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.82
    Marker Score: 549
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.79
    Marker Score: 1,508
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.79
    Marker Score: 5,897
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.77
    Marker Score: 5,041
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12,111
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,252
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.72
    Marker Score: 767
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 545
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.7
    Marker Score: 479
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.69
    Marker Score: 574
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,849
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.62
    Marker Score: 556
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.61
    Marker Score: 174
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.61
    Marker Score: 8,090
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1,245
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.59
    Marker Score: 271
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.59
    Marker Score: 623
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.58
    Marker Score: 233
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.56
    Marker Score: 704
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.56
    Marker Score: 608
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 181
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.55
    Marker Score: 1,306
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.55
    Marker Score: 272
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.55
    Marker Score: 158
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 171
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.55
    Marker Score: 255
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3,276
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.53
    Marker Score: 598
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.52
    Marker Score: 245
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1,214
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.51
    Marker Score: 2,668
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.51
    Marker Score: 4,366
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 333
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.5
    Marker Score: 147
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.49
    Marker Score: 566
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.48
    Marker Score: 710
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.48
    Marker Score: 16,690
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.48
    Marker Score: 166
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.47
    Marker Score: 671
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.47
    Marker Score: 3,639
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 431
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.46
    Marker Score: 240
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.45
    Marker Score: 1,229
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.45
    Marker Score: 5,067
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.45
    Marker Score: 4,517
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 303
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 213
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.44
    Marker Score: 108
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 702
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.43
    Marker Score: 254
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 242
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.4
    Marker Score: 614
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.39
    Marker Score: 535
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.38
    Marker Score: 651
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.38
    Marker Score: 93
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.37
    Marker Score: 201
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.37
    Marker Score: 571
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.37
    Marker Score: 256
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.37
    Marker Score: 1,807
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.37
    Marker Score: 86
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.37
    Marker Score: 225
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.37
    Marker Score: 765
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.37
    Marker Score: 331
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.37
    Marker Score: 730
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 365
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.36
    Marker Score: 148
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.36
    Marker Score: 382
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.35
    Marker Score: 142
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.35
    Marker Score: 174

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PIAS3 is a member of the PIAS (Protein Inhibitor of Activated STAT) family, which consists of six members that regulate various signaling pathways. PIAS3 is a type II PIAS, characterized by its ability to inhibit the activity of activated STAT3, a transcription factor involved in inflammation and immune response. PIAS3 is also a sumo E3 ligase, capable of sumoylating target proteins, thereby regulating their activity and localization. **Pathways and Functions:** PIAS3 is involved in multiple signaling pathways, including: 1. **Negative regulation of gene expression**: PIAS3 inhibits the activity of activated STAT3, which in turn suppresses the expression of target genes involved in inflammation and immune response. 2. **Negative regulation of osteoclast differentiation**: PIAS3 regulates the activity of key transcription factors involved in osteoclast differentiation, thereby influencing bone metabolism. 3. **Negative regulation of protein sumoylation**: PIAS3 inhibits the sumoylation of target proteins, thereby regulating their activity and localization. 4. **Regulation of transcription by RNA polymerase II**: PIAS3 regulates the activity of RNA polymerase II, a key enzyme involved in transcription. 5. **Sumoylation of DNA replication proteins**: PIAS3 regulates the sumoylation of DNA replication proteins, thereby influencing DNA repair and replication. **Significantly Expressed Cells:** PIAS3 is highly expressed in various cell types, including: 1. Pulmonary interstitial fibroblast 2. Respiratory epithelial cell 3. Nasal mucosa goblet cell 4. Cerebral cortex GABAergic interneuron 5. Forebrain radial glial cell 6. Absorptive cell 7. Intestinal crypt stem cell of colon 8. Tuft cell of colon 9. BEST4+ intestinal epithelial cell **Clinical Significance:** Dysregulation of PIAS3 has been implicated in various diseases, including: 1. **Cancer**: PIAS3 is involved in the regulation of oncogenic signaling pathways, and its dysregulation has been linked to cancer development and progression. 2. **Autoimmune disorders**: PIAS3 regulates the activity of immune response proteins, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological disorders**: PIAS3 is involved in the regulation of transcriptional control and protein sumoylation, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PIAS3 is a key regulator of protein sumoylation and immune response, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the mechanisms of PIAS3 and its role in maintaining immune homeostasis.

Genular Protein ID: 1686164322

Symbol: PIAS3_HUMAN

Name: E3 SUMO-protein ligase PIAS3

UniProtKB Accession Codes:

Q9Y6X2 Q9UFI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10319586

Title: Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3).

PubMed ID: 10319586

DOI: 10.1007/s100380050141

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9388184

Title: Specific inhibition of Stat3 signal transduction by PIAS3.

PubMed ID: 9388184

DOI: 10.1126/science.278.5344.1803

PubMed ID: 11071847

Title: Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells.

PubMed ID: 11071847

DOI: 10.1006/bbrc.2000.3753

PubMed ID: 11060035

Title: The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.

PubMed ID: 11060035

DOI: 10.1093/emboj/19.21.5845

PubMed ID: 14715251

Title: ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3.

PubMed ID: 14715251

DOI: 10.1016/j.bbrc.2003.12.054

PubMed ID: 15208321

Title: Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation.

PubMed ID: 15208321

DOI: 10.1074/jbc.m401753200

PubMed ID: 20516148

Title: TRIM8 modulates STAT3 activity through negative regulation of PIAS3.

PubMed ID: 20516148

DOI: 10.1242/jcs.068981

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 25406032

Title: Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.

PubMed ID: 25406032

DOI: 10.1038/ncomms6483

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24651376

Title: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.

PubMed ID: 24651376

DOI: 10.1371/journal.pone.0092746

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 628
  • Mass: 68017
  • Checksum: 7C06EF599D48F87D
  • Sequence:
    • MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 
YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL LAPGTLLGPK REVDMHPPLP 
QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQVQ QILTSREVLP 
GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR 
PINITPLARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS 
RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK 
KPTWTCPVCD KKAPYESLII DGLFMEILSS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP 
PGYGLDGLQY SPVQGGDPSE NKKKVEVIDL TIESSSDEED LPPTKKHCSV TSAAIPALPG 
SKGVLTSGHQ PSSVLRSPAM GTLGGDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ 
HYGPSVITSL DEQDALGHFF QYRGTPSHFL GPLAPTLGSS HCSATPAPPP GRVSSIVAPG 
GALREGHGGP LPSGPSLTGC RSDIISLD

Genular Protein ID: 1500194988

Symbol: B3KNI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNI3

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 628
  • Mass: 68001
  • Checksum: 1002AE16F00BD531
  • Sequence:
    • MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 
YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP GPLAPIPPTL LAPGTLLGPK REVDMHPPLP 
QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQVQ QILTSREVLP 
GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR 
PINITPPARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS 
RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK 
KPTWTCPVCD KKAPYESLII DGLFMEILSS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP 
PGYGLDGLQY SPVQGGDPSE NKKKVEVIDL TIESSSDEED LPPTKKHCSV TSAAIPALPG 
SKGVLTSGHQ PSSVLRSPAM GTLGGDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ 
HYGPSVITSL DEQDALGHFF QYRGTPSHFL GPLAPTLGSS HCSATPAPPP GRVSSIVAPG 
GALREGHGGP LPSGPSLTGC RSDIISLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.