Details for: ST3GAL6

Gene ID: 10402

Symbol: ST3GAL6

Ensembl ID: ENSG00000064225

Description: ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.9
    Marker Score: 3,608
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.46
    Marker Score: 54,958
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.37
    Marker Score: 41,994
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.08
    Marker Score: 7,382
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.04
    Marker Score: 19,211
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.02
    Marker Score: 1,062
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.87
    Marker Score: 931
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.82
    Marker Score: 112,216
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.78
    Marker Score: 994
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.73
    Marker Score: 1,908
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.66
    Marker Score: 15,780
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.66
    Marker Score: 990
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.63
    Marker Score: 10,486
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.62
    Marker Score: 8,705
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.59
    Marker Score: 16,422
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.59
    Marker Score: 1,923
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,149
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.55
    Marker Score: 561
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.54
    Marker Score: 6,625
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.52
    Marker Score: 890
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,043
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.46
    Marker Score: 12,514
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.41
    Marker Score: 51,961
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.4
    Marker Score: 517
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.37
    Marker Score: 1,695
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.37
    Marker Score: 1,843
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.32
    Marker Score: 482
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.29
    Marker Score: 11,246
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.29
    Marker Score: 330
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.29
    Marker Score: 1,984
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.26
    Marker Score: 2,875
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19,300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.23
    Marker Score: 2,502
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.22
    Marker Score: 998
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.21
    Marker Score: 2,843
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.18
    Marker Score: 1,362
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.16
    Marker Score: 579
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.15
    Marker Score: 566
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,773
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.12
    Marker Score: 4,579
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.1
    Marker Score: 1,190
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.08
    Marker Score: 453
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.06
    Marker Score: 4,159
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 330
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.01
    Marker Score: 38,489
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.01
    Marker Score: 488
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1
    Marker Score: 1,819
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,768
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,994
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.99
    Marker Score: 1,395
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.99
    Marker Score: 270
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.99
    Marker Score: 34,200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.98
    Marker Score: 2,351
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19,165
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.96
    Marker Score: 7,372
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.94
    Marker Score: 1,007
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.94
    Marker Score: 640
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.93
    Marker Score: 997
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.93
    Marker Score: 1,768
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.92
    Marker Score: 2,295
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 866
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,236
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.91
    Marker Score: 353
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.89
    Marker Score: 3,712
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.88
    Marker Score: 426
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.88
    Marker Score: 2,169
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.86
    Marker Score: 1,421
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3,545
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.83
    Marker Score: 218
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.82
    Marker Score: 902
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.82
    Marker Score: 259
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.82
    Marker Score: 475
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 788
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.8
    Marker Score: 254
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.8
    Marker Score: 20,427
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.78
    Marker Score: 435
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.77
    Marker Score: 26,169
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.77
    Marker Score: 12,343
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,246
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2,612
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.73
    Marker Score: 297
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.73
    Marker Score: 2,075
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7
    Marker Score: 2,284
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.69
    Marker Score: 601
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.69
    Marker Score: 3,204
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.69
    Marker Score: 257
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.68
    Marker Score: 273

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * ST3GAL6 is a sialyltransferase that catalyzes the transfer of sialic acid residues to carbohydrate molecules. * The enzyme is specifically involved in the biosynthesis of keratan sulfate and Lewis blood group antigens. * ST3GAL6 is a type II transmembrane protein, with the catalytic domain exposed to the extracellular environment. * The gene is highly expressed in cells that require complex glycosylation patterns, such as cardiac neurons and fat cells. **Pathways and Functions:** * **Asparagine N-Linked Glycosylation:** ST3GAL6 is involved in the transfer of sialic acid residues to asparagine-containing glycoproteins, which are essential for maintaining protein stability and function. * **Beta-Galactoside (cmp) Alpha-2,3-Sialyltransferase Activity:** The enzyme catalyzes the transfer of sialic acid residues to beta-galactoside-containing molecules, which is critical for the biosynthesis of keratan sulfate and Lewis blood group antigens. * **Biosynthesis of the N-Glycan Precursor (Dolichol Lipid-Linked Oligosaccharide, LLO):** ST3GAL6 is involved in the transfer of sialic acid residues to LLO, which is a precursor to N-glycans. * **Glycolipid Biosynthesis:** The enzyme is also involved in the biosynthesis of glycolipids, such as gangliosides and sulfoglycolipids, which are essential for cell signaling and recognition. **Clinical Significance:** * **Blood Group System Disorders:** Mutations in the ST3GAL6 gene have been associated with blood group system disorders, such as the ABO blood group system. * **Cardiovascular Disease:** Abnormal glycosylation patterns, resulting from mutations in the ST3GAL6 gene, have been linked to an increased risk of cardiovascular disease. * **Neurological Disorders:** ST3GAL6 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by abnormal glycosylation patterns. * **Cancer:** The enzyme has been shown to play a role in cancer development and progression, particularly in the context of glycosylation-mediated cell signaling and adhesion. In conclusion, ST3GAL6 is a critical enzyme involved in the biosynthesis of glycoproteins and glycolipids, which are essential for various cellular processes. Its dysregulation has been implicated in a range of diseases, including blood group system disorders, cardiovascular disease, neurological disorders, and cancer. Further research is needed to fully elucidate the role of ST3GAL6 in human disease and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 3305702288

Symbol: SIA10_HUMAN

Name: Type 2 lactosamine alpha-2,3-sialyltransferase

UniProtKB Accession Codes:

Q9Y274 B2RCH2 B3KMI1 D3DN39 F8W6U0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 8 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10206952

Title: Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.

PubMed ID: 10206952

DOI: 10.1074/jbc.274.17.11479

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 331
  • Mass: 38214
  • Checksum: DD2B3D88D3D0A055
  • Sequence:
    • MRGYLVAIFL SAVFLYYVLH CILWGTNVYW VAPVEMKRRN KIQPCLSKPA FASLLRFHQF 
HPFLCAADFR KIASLYGSDK FDLPYGMRTS AEYFRLALSK LQSCDLFDEF DNIPCKKCVV 
VGNGGVLKNK TLGEKIDSYD VIIRMNNGPV LGHEEEVGRR TTFRLFYPES VFSDPIHNDP 
NTTVILTAFK PHDLRWLLEL LMGDKINTNG FWKKPALNLI YKPYQIRILD PFIIRTAAYE 
LLHFPKVFPK NQKPKHPTTG IIAITLAFYI CHEVHLAGFK YNFSDLKSPL HYYGNATMSL 
MNKNAYHNVT AEQLFLKDII EKNLVINLTQ D

Genular Protein ID: 2980523990

Symbol: A0A087WXB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXB8

Database IDs:

ARBA 14 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 384
  • Mass: 43471
  • Checksum: 2E9627CF90AEFC33
  • Sequence:
    • MWQAPRERQQ PAGAAAPQVS EPGAPLRSSL LGLGGSLLPA GFAAGLHCPG EPAMRGYLVA 
IFLSAVFLYY VLHCILWGTN VYWVAPVEMK RRNKIQPCLS KPAFASLLRF HQFHPFLCAA 
DFRKIASLYG SDKFDLPYGM RTSAEYFRLA LSKLQSCDLF DEFDNIPCKK CVVVGNGGVL 
KNKTLGEKID SYDVIIRMNN GPVLGHEEEV GRRTTFRLFY PESVFSDPIH NDPNTTVILT 
AFKPHDLRWL LELLMGDKIN TNGFWKKPAL NLIYKPYQIR ILDPFIIRTA AYELLHFPKV 
FPKNQKPKHP TTGIIAITLA FYICHEVHLA GFKYNFSDLK SPLHYYGNAT MSLMNKNAYH 
NVTAEQLFLK DIIEKNLVIN LTQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.