Details for: CPQ

Gene ID: 10404

Symbol: CPQ

Ensembl ID: ENSG00000104324

Description: carboxypeptidase Q

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.05
    Marker Score: 3,689
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.96
    Marker Score: 2,320
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.75
    Marker Score: 3,698
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.68
    Marker Score: 57,266
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.58
    Marker Score: 3,215
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.52
    Marker Score: 4,839
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.43
    Marker Score: 1,281
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.37
    Marker Score: 2,726
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.32
    Marker Score: 8,234
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.28
    Marker Score: 1,333
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.12
    Marker Score: 1,236
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.09
    Marker Score: 8,764
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.08
    Marker Score: 4,978
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.04
    Marker Score: 1,010
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.04
    Marker Score: 6,687
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.01
    Marker Score: 1,921
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2
    Marker Score: 1,538
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.86
    Marker Score: 429
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.83
    Marker Score: 3,730
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.79
    Marker Score: 1,175
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.78
    Marker Score: 4,758
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.77
    Marker Score: 39,494
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.76
    Marker Score: 2,920
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.75
    Marker Score: 1,517
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.75
    Marker Score: 4,410
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.74
    Marker Score: 1,146
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.74
    Marker Score: 550
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.71
    Marker Score: 619
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.69
    Marker Score: 842
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.68
    Marker Score: 1,800
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.62
    Marker Score: 600
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.61
    Marker Score: 898
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.61
    Marker Score: 4,222
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.59
    Marker Score: 5,636
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.56
    Marker Score: 6,720
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 454
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.54
    Marker Score: 15,935
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.54
    Marker Score: 558
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.53
    Marker Score: 1,551
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.52
    Marker Score: 1,639
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.45
    Marker Score: 1,237
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.44
    Marker Score: 1,527
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.43
    Marker Score: 3,131
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.42
    Marker Score: 402
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.4
    Marker Score: 761
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.39
    Marker Score: 436
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.38
    Marker Score: 1,899
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.37
    Marker Score: 434
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.37
    Marker Score: 3,227
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.36
    Marker Score: 762
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.35
    Marker Score: 8,661
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.33
    Marker Score: 1,289
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.33
    Marker Score: 453
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.31
    Marker Score: 49,855
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20,090
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.28
    Marker Score: 1,326
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.27
    Marker Score: 1,274
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.27
    Marker Score: 510
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.26
    Marker Score: 14,168
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.24
    Marker Score: 42,304
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.23
    Marker Score: 517
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.23
    Marker Score: 880
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.23
    Marker Score: 1,516
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.23
    Marker Score: 462
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.22
    Marker Score: 726
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.21
    Marker Score: 453
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.19
    Marker Score: 578
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.17
    Marker Score: 5,047
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.16
    Marker Score: 700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.15
    Marker Score: 477
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.15
    Marker Score: 669
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.15
    Marker Score: 297
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.14
    Marker Score: 281
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.13
    Marker Score: 458
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.12
    Marker Score: 6,040
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.12
    Marker Score: 1,587
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.11
    Marker Score: 1,706
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.1
    Marker Score: 1,173
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.09
    Marker Score: 458
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.08
    Marker Score: 6,514
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.07
    Marker Score: 6,958
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.06
    Marker Score: 270
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.06
    Marker Score: 18,827
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.04
    Marker Score: 64,239
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.04
    Marker Score: 1,901
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.04
    Marker Score: 1,534
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.04
    Marker Score: 284
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.04
    Marker Score: 379
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.03
    Marker Score: 1,590
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.03
    Marker Score: 1,935
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.03
    Marker Score: 291
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.02
    Marker Score: 16,347
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.01
    Marker Score: 540
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.01
    Marker Score: 1,184
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.01
    Marker Score: 376
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1
    Marker Score: 2,422
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,643
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,870
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.99
    Marker Score: 652

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPQ is a metalloprotease enzyme that exhibits carboxypeptidase activity, cleaving peptides at the carboxy-terminal end. Its structure consists of a zinc-binding site, essential for catalytic activity, and a homodimeric arrangement, facilitating protein-protein interactions. CPQ is also implicated in the regulation of thyroid hormone generation and tissue regeneration, highlighting its potential role in endocrine and developmental processes. **Pathways and Functions:** CPQ participates in various cellular pathways, including: 1. **Carboxypeptidase activity:** CPQ cleaves peptides at the carboxy-terminal end, contributing to protein degradation and the regulation of cellular signaling. 2. **Protein homodimerization:** CPQ interacts with other proteins, forming homodimers that may modulate enzyme activity, substrate specificity, or protein-protein interactions. 3. **Proteolysis:** CPQ is involved in the breakdown of proteins, regulating cellular processes such as cell signaling, differentiation, and survival. 4. **Thyroid hormone generation:** CPQ is implicated in the regulation of thyroid hormone generation, highlighting its potential role in endocrine function and development. 5. **Tissue regeneration:** CPQ is expressed in various tissues, including the lens, thyroid, and brain, suggesting its involvement in tissue repair and regeneration. **Clinical Significance:** CPQ's involvement in multiple cellular processes has significant implications for human health and disease. Alterations in CPQ expression or function may contribute to: 1. **Endocrine disorders:** Dysregulation of thyroid hormone generation, potentially leading to hypothyroidism or hyperthyroidism. 2. **Neurodegenerative diseases:** Impaired CPQ function may contribute to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Tissue damage:** CPQ's role in protein degradation and tissue regeneration may be compromised in diseases characterized by tissue damage, such as cancer or cardiovascular disease. 4. **Cancer:** CPQ expression is altered in various cancers, including thyroid cancer, suggesting its potential role in tumor development or progression. In conclusion, CPQ is a multifunctional enzyme with significant implications for human physiology and pathology. Further research is needed to elucidate the precise mechanisms by which CPQ regulates cellular processes and to explore its therapeutic potential in diseases characterized by altered CPQ expression or function.

Genular Protein ID: 1509330453

Symbol: CBPQ_HUMAN

Name: Carboxypeptidase Q

UniProtKB Accession Codes:

Q9Y646 B2RD88 Q8NBZ1 Q9UNM8 Q9Y5X6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10206990

Title: Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen.

PubMed ID: 10206990

DOI: 10.1074/jbc.274.17.11742

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12675526

Title: Purification and primary structure determination of human lysosomal dipeptidase.

PubMed ID: 12675526

DOI: 10.1515/bc.2003.036

PubMed ID: 12591738

Title: Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma.

PubMed ID: 12591738

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17214548

Title: Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization.

PubMed ID: 17214548

DOI: 10.1515/bc.2007.005

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 472
  • Mass: 51888
  • Checksum: EB6CBD2149E042BF
  • Sequence:
    • MKFLIFAFFG GVHLLSLCSG KAICKNGISK RTFEEIKEEI ASCGDVAKAI INLAVYGKAQ 
NRSYERLALL VDTVGPRLSG SKNLEKAIQI MYQNLQQDGL EKVHLEPVRI PHWERGEESA 
VMLEPRIHKI AILGLGSSIG TPPEGITAEV LVVTSFDELQ RRASEARGKI VVYNQPYINY 
SRTVQYRTQG AVEAAKVGAL ASLIRSVASF SIYSPHTGIQ EYQDGVPKIP TACITVEDAE 
MMSRMASHGI KIVIQLKMGA KTYPDTDSFN TVAEITGSKY PEQVVLVSGH LDSWDVGQGA 
MDDGGGAFIS WEALSLIKDL GLRPKRTLRL VLWTAEEQGG VGAFQYYQLH KVNISNYSLV 
MESDAGTFLP TGLQFTGSEK ARAIMEEVMS LLQPLNITQV LSHGEGTDIN FWIQAGVPGA 
SLLDDLYKYF FFHHSHGDTM TVMDPKQMNV AAAVWAVVSY VVADMEEMLP RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.