Details for: WFDC2

Gene ID: 10406

Symbol: WFDC2

Ensembl ID: ENSG00000101443

Description: WAP four-disulfide core domain 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.47
    Marker Score: 11,267
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.16
    Marker Score: 7,587
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.04
    Marker Score: 21,253
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.64
    Marker Score: 2,432
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.52
    Marker Score: 8,018
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.44
    Marker Score: 9,232
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.43
    Marker Score: 29,759
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.4
    Marker Score: 933
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.4
    Marker Score: 117,815
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.35
    Marker Score: 2,988
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.29
    Marker Score: 1,623
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.24
    Marker Score: 2,554
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.22
    Marker Score: 4,561
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.21
    Marker Score: 23,877
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.16
    Marker Score: 20,618
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.13
    Marker Score: 7,644
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 3.12
    Marker Score: 989
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.05
    Marker Score: 11,750
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 3.04
    Marker Score: 1,421
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3
    Marker Score: 4,817
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.97
    Marker Score: 2,322
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.9
    Marker Score: 1,158
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.81
    Marker Score: 3,286
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.78
    Marker Score: 10,763
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.74
    Marker Score: 4,859
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.7
    Marker Score: 986
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.68
    Marker Score: 951
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.63
    Marker Score: 3,169
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.63
    Marker Score: 4,354
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.53
    Marker Score: 731
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.51
    Marker Score: 4,774
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.5
    Marker Score: 8,579
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.21
    Marker Score: 8,167
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.17
    Marker Score: 7,711
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.14
    Marker Score: 2,055
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.11
    Marker Score: 1,437
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.06
    Marker Score: 1,432
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.04
    Marker Score: 3,351
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.98
    Marker Score: 464
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.95
    Marker Score: 2,874
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.91
    Marker Score: 472
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.91
    Marker Score: 981
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.91
    Marker Score: 1,016
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.87
    Marker Score: 838
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.86
    Marker Score: 1,977
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.86
    Marker Score: 1,954
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.79
    Marker Score: 4,063
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.79
    Marker Score: 2,842
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.76
    Marker Score: 449
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.75
    Marker Score: 1,773
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.74
    Marker Score: 1,499
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.73
    Marker Score: 3,610
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.72
    Marker Score: 337
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.72
    Marker Score: 719
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.71
    Marker Score: 944
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.7
    Marker Score: 635
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.67
    Marker Score: 8,187
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.65
    Marker Score: 1,750
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.58
    Marker Score: 25,319
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.57
    Marker Score: 915
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.56
    Marker Score: 1,621
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.55
    Marker Score: 312
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.48
    Marker Score: 6,189
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.39
    Marker Score: 718
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.38
    Marker Score: 918
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.37
    Marker Score: 615
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.36
    Marker Score: 329
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.35
    Marker Score: 1,201
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 856
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.33
    Marker Score: 384
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.31
    Marker Score: 14,758
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.27
    Marker Score: 1,266
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.23
    Marker Score: 1,483
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.21
    Marker Score: 572
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2
    Marker Score: 10,553
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.18
    Marker Score: 785
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.18
    Marker Score: 831
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.12
    Marker Score: 252
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.11
    Marker Score: 507
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.1
    Marker Score: 1,431
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.06
    Marker Score: 1,143
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.04
    Marker Score: 360
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,726
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,746
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,970
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.99
    Marker Score: 286
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.99
    Marker Score: 569
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Marker Score: 2,351
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.96
    Marker Score: 915
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,340
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.94
    Marker Score: 238
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.93
    Marker Score: 5,534
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.93
    Marker Score: 663
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 670

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** WFDC2 is a secreted protein that is produced by various cell types, including epithelial cells, immune cells, and fibroblasts. It is characterized by its four disulfide core domains, which confer stability and structural integrity to the protein. WFDC2 is also known to interact with other proteins, including enzymes and receptors, to regulate various cellular processes. **Pathways and Functions** WFDC2 is involved in several key pathways, including: 1. **Antibacterial Humoral Response**: WFDC2 is expressed in response to bacterial challenges, and its expression is significantly elevated in the kidney and lung. This suggests that WFDC2 plays a role in the innate immune response against bacterial infections. 2. **Endopeptidase Inhibition**: WFDC2 has been shown to inhibit the activity of endopeptidases, enzymes that break down proteins. This inhibition is thought to regulate protein degradation and maintain tissue homeostasis. 3. **Developmental Biology**: WFDC2 is expressed during embryonic development and is involved in the formation of the nephric duct, a critical structure in kidney development. 4. **Proteolysis**: WFDC2 is also involved in regulating proteolysis, a process that involves the degradation of proteins. **Clinical Significance** WFDC2 has been implicated in various diseases, including: 1. **Kidney Disease**: WFDC2 expression is altered in patients with kidney disease, suggesting that it may play a role in the pathogenesis of kidney disease. 2. **Respiratory Diseases**: WFDC2 expression is elevated in patients with respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 3. **Cancer**: WFDC2 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. In conclusion, WFDC2 is a multifaceted gene that plays a critical role in immune response, development, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying WFDC2 function.

Genular Protein ID: 3303530464

Symbol: WFDC2_HUMAN

Name: WAP four-disulfide core domain protein 2

UniProtKB Accession Codes:

Q14508 A2A2A5 A2A2A6 A6PVD5 Q6IB27 Q8WXV9 Q8WXW0 Q8WXW1 Q8WXW2 Q96KJ1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1686187

Title: A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors.

PubMed ID: 1686187

DOI: 10.1095/biolreprod45.2.350

PubMed ID: 11965550

Title: The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms.

PubMed ID: 11965550

DOI: 10.1038/sj.onc.1205363

PubMed ID: 12839961

Title: The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.

PubMed ID: 12839961

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15781627

Title: Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.

PubMed ID: 15781627

DOI: 10.1158/0008-5472.can-04-3924

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 23139753

Title: Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor.

PubMed ID: 23139753

DOI: 10.1371/journal.pone.0047672

Sequence Information:

  • Length: 124
  • Mass: 12993
  • Checksum: 9536B00B385259AD
  • Sequence:
    • MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK 
CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV 
TPNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.