Details for: SPAG11B

Gene ID: 10407

Symbol: SPAG11B

Ensembl ID: ENSG00000164871

Description: sperm associated antigen 11B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.66
    Marker Score: 8,238
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30,388
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.74
    Marker Score: 6,804
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3,162
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2,216
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,213
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.06
    Marker Score: 558
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6,831
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,688
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,959
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.94
    Marker Score: 1,618
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,339
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1,461
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,281
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.77
    Marker Score: 240
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,199
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.73
    Marker Score: 187
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.73
    Marker Score: 402
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 700
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 540
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.64
    Marker Score: 234
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.59
    Marker Score: 818
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.58
    Marker Score: 198
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 356
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.52
    Marker Score: 239
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 386
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 215
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.38
    Marker Score: 202
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.35
    Marker Score: 370
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 110
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.3
    Marker Score: 232
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 571
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 235
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.26
    Marker Score: 196
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.24
    Marker Score: 215
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.22
    Marker Score: 228
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.19
    Marker Score: 218
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.17
    Marker Score: 240
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 185
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.16
    Marker Score: 174
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.16
    Marker Score: 295
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.16
    Marker Score: 207
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.15
    Marker Score: 241
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.14
    Marker Score: 235
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 429
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.13
    Marker Score: 222
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.13
    Marker Score: 238
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.12
    Marker Score: 241
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 356
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.08
    Marker Score: 241
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.08
    Marker Score: 241
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 175
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 246
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 184
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.06
    Marker Score: 240
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 186
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.05
    Marker Score: 207
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.05
    Marker Score: 499
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.04
    Marker Score: 241
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.03
    Marker Score: 222
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.03
    Marker Score: 226
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.02
    Marker Score: 227
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.02
    Marker Score: 239
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.01
    Marker Score: 499
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.01
    Marker Score: 239
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.01
    Marker Score: 234
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0
    Marker Score: 987
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 240

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPAG11B is a gene that encodes a protein, SG11A_HUMAN (Sperm antigen HE2), which is primarily expressed in cells of the immune system, including B cells, plasma cells, and hematopoietic stem cells. This protein is also found in oligodendrocyte precursor cells, progenitor cells, microglial cells, and endothelial cells, highlighting its widespread expression in various cell types. Notably, SPAG11B is significantly upregulated in response to bacterial infections, suggesting its role in the antimicrobial humoral immune response mediated by antimicrobial peptides. **Pathways and Functions:** The SPAG11B gene is involved in several key pathways, including: 1. **Antimicrobial humoral immune response mediated by antimicrobial peptide**: SPAG11B plays a crucial role in the production and regulation of antimicrobial peptides, which are essential for defending against bacterial infections. 2. **Defense response to bacterium**: The gene is also involved in the defense response to bacterial infections, highlighting its importance in maintaining host immunity. 3. **Spermatogenesis**: Interestingly, SPAG11B has been implicated in spermatogenesis, the process of sperm development and maturation. This suggests that this gene may have a role in reproductive biology, beyond its well-known involvement in the immune system. **Clinical Significance:** The clinical significance of SPAG11B is multifaceted: 1. **Immunodeficiency disorders**: Mutations in the SPAG11B gene have been associated with immunodeficiency disorders, highlighting its importance in the development and function of the immune system. 2. **Autoimmune diseases**: The gene's involvement in the antimicrobial humoral immune response may also contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Reproductive health**: The discovery of SPAG11B's role in spermatogenesis has significant implications for reproductive health, particularly in the context of male infertility and the development of novel therapeutic strategies. In conclusion, the SPAG11B gene is a complex and multifaceted component of the human genome, with significant implications for our understanding of immune function, reproductive biology, and disease. Further research is needed to fully elucidate the mechanisms by which SPAG11B regulates the immune response and spermatogenesis, and to explore its potential therapeutic applications.

Genular Protein ID: 1066454057

Symbol: SG11A_HUMAN

Name: Sperm antigen HE2

UniProtKB Accession Codes:

Q6PDA7 A6NIY0 E9PAK7

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CTD 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 2 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 2 STRING 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10698202

Title: HE2 beta and HE2 gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human.

PubMed ID: 10698202

DOI: 10.1210/endo.141.3.7389

PubMed ID: 11259252

Title: Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes.

PubMed ID: 11259252

DOI: 10.1095/biolreprod64.4.1072

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 123
  • Mass: 13842
  • Checksum: 8B500B9E045C0EFB
  • Sequence:
    • MRQRLLPSVT SLLLVALLFP GSSQARHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR 
DLLPPRTPPY QVHISHQEAR GPSFKICVGF LGPRWARGCS TGNEKYHLPY AARDLQTFFL 
PFW

Genular Protein ID: 1625726581

Symbol: SG11B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q08648 E9PFH0 Q546A0 Q6ZYB2 Q9H4P8 Q9H4P9 Q9H4Q0 Q9H4Q1 Q9H4Q2 Q9NRT3 Q9NRV4 Q9NRV5 Q9NRV6 Q9NRV7 Q9NRV8

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 2 EMBL 12 Ensembl 9 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 8 SignaLink 1 TCDB 1 TopDownProteomics 1 UCSC 1 UniProtKB 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 8167223

Title: Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis.

PubMed ID: 8167223

DOI: 10.1095/biolreprod50.3.516

PubMed ID: 10698202

Title: HE2 beta and HE2 gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human.

PubMed ID: 10698202

DOI: 10.1210/endo.141.3.7389

PubMed ID: 11259252

Title: Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes.

PubMed ID: 11259252

DOI: 10.1095/biolreprod64.4.1072

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 103
  • Mass: 11431
  • Checksum: ABDD1CE4BB54ABD3
  • Sequence:
    • MRQRLLPSVT SLLLVALLFP GSSQARHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR 
DLLPPRTPPY QVHISHREAR GPSFRICVDF LGPRWARGCS TGN

Genular Protein ID: 3467295085

Symbol: A0A0A0MRG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRG4

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 108
  • Mass: 11988
  • Checksum: 55FDB8A717E54431
  • Sequence:
    • MRQRLLPSVT SLLLVALLFP GSSQARHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR 
DLLPPRTPPY QGDVPPGIRN TICHMQQGIC RLFFCHSGTG QQHRQRCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.